8I71
Hepatitis B virus core protein Y132A mutant in complex with Linvencorvir (RG7907), a Hepatitis B Virus (HBV) Core Protein Allosteric Modulator (CpAM)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Capsid protein | polymer | 155 | 17486.9 | 6 | UniProt (P03147) Pfam (PF00906) In PDB | Hepatitis B virus subtype adyw | Core antigen,Core protein,HBcAg,p21.5 |
2 | E, A, C, D | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
3 | F, A, B, C, D | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 9 | Chemie (IPA) | |||
4 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
5 | E, F, A, B, C... | 3-[(8~{a}~{S})-7-[[5-ethoxycarbonyl-4-(3-fluoranyl-2-methyl-phenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-3-oxidanylidene-5,6,8,8~{a}-tetrahydro-1~{H}-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethyl-propanoic acid | non-polymer | 598.7 | 6 | Chemie (OTI) | |||
6 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
7 | water | water | 18.0 | 703 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 149 (UniProt: P03147)
PDB | External Database | Details |
---|---|---|
Ala 132 | Tyr 132 | engineered mutation |
Glu 150 | - | expression tag |
Asn 151 | - | expression tag |
Leu 152 | - | expression tag |
Tyr 153 | - | expression tag |
Phe 154 | - | expression tag |
Gln 155 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 104921.5 | |
Non-Polymers* | Number of molecules | 25 |
Total formula weight | 4756.8 | |
All* | Total formula weight | 109678.3 |