8I6D

Crystal structure of Mycobacterium tuberculosis Uracil-DNA glycosylase in complex with 5-Hydroxy-2,4(1H,3H)-pyrimidinedione, Form VI

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Uracil-DNA glycosylase	polymer	238	25813.5	2	UniProt (P9WFQ9) Pfam (PF03167) In PDB	Mycobacterium tuberculosis H37Rv	UDG
2	A, B	5-oxidanyl-1~{H}-pyrimidine-2,4-dione	non-polymer		128.1	3	Chemie (ODF)
3	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	B	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5		water	water		18.0	141	Chemie (HOH)

Sequence modifications

A, B: 1 - 227 (UniProt: P9WFQ9)

PDB	External Database	Details
Met -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51627.1
Non-Polymers*	Number of molecules	5
	Total formula weight	552.4
All*	Total formula weight	52179.5

*Water molecules are not included.