8I5F

Crystal structure of the DHR-2 domain of DOCK10 in complex with Cdc42 (T17N mutant)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Dedicator of cytokinesis protein 10	polymer	494	56989.9	2	UniProt (Q8BZN6) Pfam (PF06920) Pfam (PF20422) Pfam (PF20421)	Mus musculus (house mouse)	Zizimin-3
2	B, D (C, D)	Cell division control protein 42 homolog	polymer	195	21474.5	2	UniProt (P60953) Pfam (PF00071)	Homo sapiens (human)	G25K GTP-binding protein
3	E, F, G (A, C, B)	water	water		18.0	32	Chemie (HOH)

Sequence modifications

A, B: 1664 - 2150 (UniProt: Q8BZN6)

PDB	External Database	Details
Gly 1657	-	expression tag
Ser 1658	-	expression tag
Ser 1659	-	expression tag
Gly 1660	-	expression tag
Ser 1661	-	expression tag
Ser 1662	-	expression tag
Gly 1663	-	expression tag

C, D: 1 - 188 (UniProt: P60953)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Asn 17	Thr 17	engineered mutation
Ser 188	Cys 188	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	156928.8
All*	Total formula weight	156928.8

*Water molecules are not included.