8I5C
Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, EA, F, JA, K... (A, F, K, P, U...) | MHC class I antigen (Fragment) | polymer | 274 | 31753.0 | 10 | UniProt (U5YJJ6) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | AA, B, FA, G, KA... (B, G, L, Q, V...) | Beta-2-microglobulin | polymer | 99 | 11748.2 | 10 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 3 | BA, C, GA, H, LA... (C, H, M, R, W...) | peptide KRAS-G12V-9 | polymer | 9 | 786.0 | 10 | UniProt (by SIFTS) (P01116) | Homo sapiens | |
| 4 | CA, D, HA, I, MA... (D, I, N, S, X...) | TCR alpha chain | polymer | 199 | 22412.9 | 10 | Mus musculus | ||
| 5 | DA, E, IA, J, NA... (E, J, O, T, Y...) | TCR beta chain | polymer | 242 | 27028.8 | 10 | Mus musculus |
Sequence modifications
A, F, K, P, U, Z, e, j, o, t: 1 - 274 (UniProt: U5YJJ6)
| PDB | External Database | Details |
|---|---|---|
| Val 245 | Ala 269 | engineered mutation |
| Gln 253 | Glu 277 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 50 |
| Total formula weight | 937287.9 | |
| All* | Total formula weight | 937287.9 |
