8I5C

Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010038	biological_process	response to metal ion
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0033077	biological_process	T cell differentiation in thymus
B	0033572	biological_process	transferrin transport
B	0034756	biological_process	regulation of iron ion transport
B	0034757	biological_process	negative regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0048261	biological_process	negative regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
G	0000139	cellular_component	Golgi membrane
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002376	biological_process	immune system process
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010038	biological_process	response to metal ion
G	0010977	biological_process	negative regulation of neuron projection development
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0033077	biological_process	T cell differentiation in thymus
G	0033572	biological_process	transferrin transport
G	0034756	biological_process	regulation of iron ion transport
G	0034757	biological_process	negative regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0048261	biological_process	negative regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
L	0000139	cellular_component	Golgi membrane
L	0001913	biological_process	T cell mediated cytotoxicity
L	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
L	0002237	biological_process	response to molecule of bacterial origin
L	0002376	biological_process	immune system process
L	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
L	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
L	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
L	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
L	0002726	biological_process	positive regulation of T cell cytokine production
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005765	cellular_component	lysosomal membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005788	cellular_component	endoplasmic reticulum lumen
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0006955	biological_process	immune response
L	0007608	biological_process	sensory perception of smell
L	0007611	biological_process	learning or memory
L	0009897	cellular_component	external side of plasma membrane
L	0009986	cellular_component	cell surface
L	0010038	biological_process	response to metal ion
L	0010977	biological_process	negative regulation of neuron projection development
L	0012507	cellular_component	ER to Golgi transport vesicle membrane
L	0016020	cellular_component	membrane
L	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
L	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
L	0023026	molecular_function	MHC class II protein complex binding
L	0030670	cellular_component	phagocytic vesicle membrane
L	0031901	cellular_component	early endosome membrane
L	0031902	cellular_component	late endosome membrane
L	0031905	cellular_component	early endosome lumen
L	0033077	biological_process	T cell differentiation in thymus
L	0033572	biological_process	transferrin transport
L	0034756	biological_process	regulation of iron ion transport
L	0034757	biological_process	negative regulation of iron ion transport
L	0035580	cellular_component	specific granule lumen
L	0042026	biological_process	protein refolding
L	0042605	molecular_function	peptide antigen binding
L	0042612	cellular_component	MHC class I protein complex
L	0042613	cellular_component	MHC class II protein complex
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0042824	cellular_component	MHC class I peptide loading complex
L	0045646	biological_process	regulation of erythrocyte differentiation
L	0048260	biological_process	positive regulation of receptor-mediated endocytosis
L	0048261	biological_process	negative regulation of receptor-mediated endocytosis
L	0050680	biological_process	negative regulation of epithelial cell proliferation
L	0050768	biological_process	negative regulation of neurogenesis
L	0050778	biological_process	positive regulation of immune response
L	0050870	biological_process	positive regulation of T cell activation
L	0051289	biological_process	protein homotetramerization
L	0055038	cellular_component	recycling endosome membrane
L	0060586	biological_process	multicellular organismal-level iron ion homeostasis
L	0070062	cellular_component	extracellular exosome
L	0071281	biological_process	cellular response to iron ion
L	0071283	biological_process	cellular response to iron(III) ion
L	0071316	biological_process	cellular response to nicotine
L	1904724	cellular_component	tertiary granule lumen
L	1990000	biological_process	amyloid fibril formation
L	1990712	cellular_component	HFE-transferrin receptor complex
L	2000774	biological_process	positive regulation of cellular senescence
L	2000978	biological_process	negative regulation of forebrain neuron differentiation
Q	0000139	cellular_component	Golgi membrane
Q	0001913	biological_process	T cell mediated cytotoxicity
Q	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
Q	0002237	biological_process	response to molecule of bacterial origin
Q	0002376	biological_process	immune system process
Q	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
Q	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Q	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
Q	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
Q	0002726	biological_process	positive regulation of T cell cytokine production
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005765	cellular_component	lysosomal membrane
Q	0005783	cellular_component	endoplasmic reticulum
Q	0005788	cellular_component	endoplasmic reticulum lumen
Q	0005794	cellular_component	Golgi apparatus
Q	0005829	cellular_component	cytosol
Q	0005886	cellular_component	plasma membrane
Q	0005925	cellular_component	focal adhesion
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0006955	biological_process	immune response
Q	0007608	biological_process	sensory perception of smell
Q	0007611	biological_process	learning or memory
Q	0009897	cellular_component	external side of plasma membrane
Q	0009986	cellular_component	cell surface
Q	0010038	biological_process	response to metal ion
Q	0010977	biological_process	negative regulation of neuron projection development
Q	0012507	cellular_component	ER to Golgi transport vesicle membrane
Q	0016020	cellular_component	membrane
Q	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
Q	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
Q	0023026	molecular_function	MHC class II protein complex binding
Q	0030670	cellular_component	phagocytic vesicle membrane
Q	0031901	cellular_component	early endosome membrane
Q	0031902	cellular_component	late endosome membrane
Q	0031905	cellular_component	early endosome lumen
Q	0033077	biological_process	T cell differentiation in thymus
Q	0033572	biological_process	transferrin transport
Q	0034756	biological_process	regulation of iron ion transport
Q	0034757	biological_process	negative regulation of iron ion transport
Q	0035580	cellular_component	specific granule lumen
Q	0042026	biological_process	protein refolding
Q	0042605	molecular_function	peptide antigen binding
Q	0042612	cellular_component	MHC class I protein complex
Q	0042613	cellular_component	MHC class II protein complex
Q	0042802	molecular_function	identical protein binding
Q	0042803	molecular_function	protein homodimerization activity
Q	0042824	cellular_component	MHC class I peptide loading complex
Q	0045646	biological_process	regulation of erythrocyte differentiation
Q	0048260	biological_process	positive regulation of receptor-mediated endocytosis
Q	0048261	biological_process	negative regulation of receptor-mediated endocytosis
Q	0050680	biological_process	negative regulation of epithelial cell proliferation
Q	0050768	biological_process	negative regulation of neurogenesis
Q	0050778	biological_process	positive regulation of immune response
Q	0050870	biological_process	positive regulation of T cell activation
Q	0051289	biological_process	protein homotetramerization
Q	0055038	cellular_component	recycling endosome membrane
Q	0060586	biological_process	multicellular organismal-level iron ion homeostasis
Q	0070062	cellular_component	extracellular exosome
Q	0071281	biological_process	cellular response to iron ion
Q	0071283	biological_process	cellular response to iron(III) ion
Q	0071316	biological_process	cellular response to nicotine
Q	1904724	cellular_component	tertiary granule lumen
Q	1990000	biological_process	amyloid fibril formation
Q	1990712	cellular_component	HFE-transferrin receptor complex
Q	2000774	biological_process	positive regulation of cellular senescence
Q	2000978	biological_process	negative regulation of forebrain neuron differentiation
V	0000139	cellular_component	Golgi membrane
V	0001913	biological_process	T cell mediated cytotoxicity
V	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
V	0002237	biological_process	response to molecule of bacterial origin
V	0002376	biological_process	immune system process
V	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
V	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
V	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
V	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
V	0002726	biological_process	positive regulation of T cell cytokine production
V	0005198	molecular_function	structural molecule activity
V	0005515	molecular_function	protein binding
V	0005576	cellular_component	extracellular region
V	0005615	cellular_component	extracellular space
V	0005765	cellular_component	lysosomal membrane
V	0005783	cellular_component	endoplasmic reticulum
V	0005788	cellular_component	endoplasmic reticulum lumen
V	0005794	cellular_component	Golgi apparatus
V	0005829	cellular_component	cytosol
V	0005886	cellular_component	plasma membrane
V	0005925	cellular_component	focal adhesion
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0006955	biological_process	immune response
V	0007608	biological_process	sensory perception of smell
V	0007611	biological_process	learning or memory
V	0009897	cellular_component	external side of plasma membrane
V	0009986	cellular_component	cell surface
V	0010038	biological_process	response to metal ion
V	0010977	biological_process	negative regulation of neuron projection development
V	0012507	cellular_component	ER to Golgi transport vesicle membrane
V	0016020	cellular_component	membrane
V	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
V	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
V	0023026	molecular_function	MHC class II protein complex binding
V	0030670	cellular_component	phagocytic vesicle membrane
V	0031901	cellular_component	early endosome membrane
V	0031902	cellular_component	late endosome membrane
V	0031905	cellular_component	early endosome lumen
V	0033077	biological_process	T cell differentiation in thymus
V	0033572	biological_process	transferrin transport
V	0034756	biological_process	regulation of iron ion transport
V	0034757	biological_process	negative regulation of iron ion transport
V	0035580	cellular_component	specific granule lumen
V	0042026	biological_process	protein refolding
V	0042605	molecular_function	peptide antigen binding
V	0042612	cellular_component	MHC class I protein complex
V	0042613	cellular_component	MHC class II protein complex
V	0042802	molecular_function	identical protein binding
V	0042803	molecular_function	protein homodimerization activity
V	0042824	cellular_component	MHC class I peptide loading complex
V	0045646	biological_process	regulation of erythrocyte differentiation
V	0048260	biological_process	positive regulation of receptor-mediated endocytosis
V	0048261	biological_process	negative regulation of receptor-mediated endocytosis
V	0050680	biological_process	negative regulation of epithelial cell proliferation
V	0050768	biological_process	negative regulation of neurogenesis
V	0050778	biological_process	positive regulation of immune response
V	0050870	biological_process	positive regulation of T cell activation
V	0051289	biological_process	protein homotetramerization
V	0055038	cellular_component	recycling endosome membrane
V	0060586	biological_process	multicellular organismal-level iron ion homeostasis
V	0070062	cellular_component	extracellular exosome
V	0071281	biological_process	cellular response to iron ion
V	0071283	biological_process	cellular response to iron(III) ion
V	0071316	biological_process	cellular response to nicotine
V	1904724	cellular_component	tertiary granule lumen
V	1990000	biological_process	amyloid fibril formation
V	1990712	cellular_component	HFE-transferrin receptor complex
V	2000774	biological_process	positive regulation of cellular senescence
V	2000978	biological_process	negative regulation of forebrain neuron differentiation
a	0000139	cellular_component	Golgi membrane
a	0001913	biological_process	T cell mediated cytotoxicity
a	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
a	0002237	biological_process	response to molecule of bacterial origin
a	0002376	biological_process	immune system process
a	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
a	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
a	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
a	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
a	0002726	biological_process	positive regulation of T cell cytokine production
a	0005198	molecular_function	structural molecule activity
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005615	cellular_component	extracellular space
a	0005765	cellular_component	lysosomal membrane
a	0005783	cellular_component	endoplasmic reticulum
a	0005788	cellular_component	endoplasmic reticulum lumen
a	0005794	cellular_component	Golgi apparatus
a	0005829	cellular_component	cytosol
a	0005886	cellular_component	plasma membrane
a	0005925	cellular_component	focal adhesion
a	0006826	biological_process	iron ion transport
a	0006879	biological_process	intracellular iron ion homeostasis
a	0006955	biological_process	immune response
a	0007608	biological_process	sensory perception of smell
a	0007611	biological_process	learning or memory
a	0009897	cellular_component	external side of plasma membrane
a	0009986	cellular_component	cell surface
a	0010038	biological_process	response to metal ion
a	0010977	biological_process	negative regulation of neuron projection development
a	0012507	cellular_component	ER to Golgi transport vesicle membrane
a	0016020	cellular_component	membrane
a	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
a	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
a	0023026	molecular_function	MHC class II protein complex binding
a	0030670	cellular_component	phagocytic vesicle membrane
a	0031901	cellular_component	early endosome membrane
a	0031902	cellular_component	late endosome membrane
a	0031905	cellular_component	early endosome lumen
a	0033077	biological_process	T cell differentiation in thymus
a	0033572	biological_process	transferrin transport
a	0034756	biological_process	regulation of iron ion transport
a	0034757	biological_process	negative regulation of iron ion transport
a	0035580	cellular_component	specific granule lumen
a	0042026	biological_process	protein refolding
a	0042605	molecular_function	peptide antigen binding
a	0042612	cellular_component	MHC class I protein complex
a	0042613	cellular_component	MHC class II protein complex
a	0042802	molecular_function	identical protein binding
a	0042803	molecular_function	protein homodimerization activity
a	0042824	cellular_component	MHC class I peptide loading complex
a	0045646	biological_process	regulation of erythrocyte differentiation
a	0048260	biological_process	positive regulation of receptor-mediated endocytosis
a	0048261	biological_process	negative regulation of receptor-mediated endocytosis
a	0050680	biological_process	negative regulation of epithelial cell proliferation
a	0050768	biological_process	negative regulation of neurogenesis
a	0050778	biological_process	positive regulation of immune response
a	0050870	biological_process	positive regulation of T cell activation
a	0051289	biological_process	protein homotetramerization
a	0055038	cellular_component	recycling endosome membrane
a	0060586	biological_process	multicellular organismal-level iron ion homeostasis
a	0070062	cellular_component	extracellular exosome
a	0071281	biological_process	cellular response to iron ion
a	0071283	biological_process	cellular response to iron(III) ion
a	0071316	biological_process	cellular response to nicotine
a	1904724	cellular_component	tertiary granule lumen
a	1990000	biological_process	amyloid fibril formation
a	1990712	cellular_component	HFE-transferrin receptor complex
a	2000774	biological_process	positive regulation of cellular senescence
a	2000978	biological_process	negative regulation of forebrain neuron differentiation
f	0000139	cellular_component	Golgi membrane
f	0001913	biological_process	T cell mediated cytotoxicity
f	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
f	0002237	biological_process	response to molecule of bacterial origin
f	0002376	biological_process	immune system process
f	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
f	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
f	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
f	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
f	0002726	biological_process	positive regulation of T cell cytokine production
f	0005198	molecular_function	structural molecule activity
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005615	cellular_component	extracellular space
f	0005765	cellular_component	lysosomal membrane
f	0005783	cellular_component	endoplasmic reticulum
f	0005788	cellular_component	endoplasmic reticulum lumen
f	0005794	cellular_component	Golgi apparatus
f	0005829	cellular_component	cytosol
f	0005886	cellular_component	plasma membrane
f	0005925	cellular_component	focal adhesion
f	0006826	biological_process	iron ion transport
f	0006879	biological_process	intracellular iron ion homeostasis
f	0006955	biological_process	immune response
f	0007608	biological_process	sensory perception of smell
f	0007611	biological_process	learning or memory
f	0009897	cellular_component	external side of plasma membrane
f	0009986	cellular_component	cell surface
f	0010038	biological_process	response to metal ion
f	0010977	biological_process	negative regulation of neuron projection development
f	0012507	cellular_component	ER to Golgi transport vesicle membrane
f	0016020	cellular_component	membrane
f	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
f	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
f	0023026	molecular_function	MHC class II protein complex binding
f	0030670	cellular_component	phagocytic vesicle membrane
f	0031901	cellular_component	early endosome membrane
f	0031902	cellular_component	late endosome membrane
f	0031905	cellular_component	early endosome lumen
f	0033077	biological_process	T cell differentiation in thymus
f	0033572	biological_process	transferrin transport
f	0034756	biological_process	regulation of iron ion transport
f	0034757	biological_process	negative regulation of iron ion transport
f	0035580	cellular_component	specific granule lumen
f	0042026	biological_process	protein refolding
f	0042605	molecular_function	peptide antigen binding
f	0042612	cellular_component	MHC class I protein complex
f	0042613	cellular_component	MHC class II protein complex
f	0042802	molecular_function	identical protein binding
f	0042803	molecular_function	protein homodimerization activity
f	0042824	cellular_component	MHC class I peptide loading complex
f	0045646	biological_process	regulation of erythrocyte differentiation
f	0048260	biological_process	positive regulation of receptor-mediated endocytosis
f	0048261	biological_process	negative regulation of receptor-mediated endocytosis
f	0050680	biological_process	negative regulation of epithelial cell proliferation
f	0050768	biological_process	negative regulation of neurogenesis
f	0050778	biological_process	positive regulation of immune response
f	0050870	biological_process	positive regulation of T cell activation
f	0051289	biological_process	protein homotetramerization
f	0055038	cellular_component	recycling endosome membrane
f	0060586	biological_process	multicellular organismal-level iron ion homeostasis
f	0070062	cellular_component	extracellular exosome
f	0071281	biological_process	cellular response to iron ion
f	0071283	biological_process	cellular response to iron(III) ion
f	0071316	biological_process	cellular response to nicotine
f	1904724	cellular_component	tertiary granule lumen
f	1990000	biological_process	amyloid fibril formation
f	1990712	cellular_component	HFE-transferrin receptor complex
f	2000774	biological_process	positive regulation of cellular senescence
f	2000978	biological_process	negative regulation of forebrain neuron differentiation
k	0000139	cellular_component	Golgi membrane
k	0001913	biological_process	T cell mediated cytotoxicity
k	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
k	0002237	biological_process	response to molecule of bacterial origin
k	0002376	biological_process	immune system process
k	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
k	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
k	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
k	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
k	0002726	biological_process	positive regulation of T cell cytokine production
k	0005198	molecular_function	structural molecule activity
k	0005515	molecular_function	protein binding
k	0005576	cellular_component	extracellular region
k	0005615	cellular_component	extracellular space
k	0005765	cellular_component	lysosomal membrane
k	0005783	cellular_component	endoplasmic reticulum
k	0005788	cellular_component	endoplasmic reticulum lumen
k	0005794	cellular_component	Golgi apparatus
k	0005829	cellular_component	cytosol
k	0005886	cellular_component	plasma membrane
k	0005925	cellular_component	focal adhesion
k	0006826	biological_process	iron ion transport
k	0006879	biological_process	intracellular iron ion homeostasis
k	0006955	biological_process	immune response
k	0007608	biological_process	sensory perception of smell
k	0007611	biological_process	learning or memory
k	0009897	cellular_component	external side of plasma membrane
k	0009986	cellular_component	cell surface
k	0010038	biological_process	response to metal ion
k	0010977	biological_process	negative regulation of neuron projection development
k	0012507	cellular_component	ER to Golgi transport vesicle membrane
k	0016020	cellular_component	membrane
k	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
k	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
k	0023026	molecular_function	MHC class II protein complex binding
k	0030670	cellular_component	phagocytic vesicle membrane
k	0031901	cellular_component	early endosome membrane
k	0031902	cellular_component	late endosome membrane
k	0031905	cellular_component	early endosome lumen
k	0033077	biological_process	T cell differentiation in thymus
k	0033572	biological_process	transferrin transport
k	0034756	biological_process	regulation of iron ion transport
k	0034757	biological_process	negative regulation of iron ion transport
k	0035580	cellular_component	specific granule lumen
k	0042026	biological_process	protein refolding
k	0042605	molecular_function	peptide antigen binding
k	0042612	cellular_component	MHC class I protein complex
k	0042613	cellular_component	MHC class II protein complex
k	0042802	molecular_function	identical protein binding
k	0042803	molecular_function	protein homodimerization activity
k	0042824	cellular_component	MHC class I peptide loading complex
k	0045646	biological_process	regulation of erythrocyte differentiation
k	0048260	biological_process	positive regulation of receptor-mediated endocytosis
k	0048261	biological_process	negative regulation of receptor-mediated endocytosis
k	0050680	biological_process	negative regulation of epithelial cell proliferation
k	0050768	biological_process	negative regulation of neurogenesis
k	0050778	biological_process	positive regulation of immune response
k	0050870	biological_process	positive regulation of T cell activation
k	0051289	biological_process	protein homotetramerization
k	0055038	cellular_component	recycling endosome membrane
k	0060586	biological_process	multicellular organismal-level iron ion homeostasis
k	0070062	cellular_component	extracellular exosome
k	0071281	biological_process	cellular response to iron ion
k	0071283	biological_process	cellular response to iron(III) ion
k	0071316	biological_process	cellular response to nicotine
k	1904724	cellular_component	tertiary granule lumen
k	1990000	biological_process	amyloid fibril formation
k	1990712	cellular_component	HFE-transferrin receptor complex
k	2000774	biological_process	positive regulation of cellular senescence
k	2000978	biological_process	negative regulation of forebrain neuron differentiation
p	0000139	cellular_component	Golgi membrane
p	0001913	biological_process	T cell mediated cytotoxicity
p	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
p	0002237	biological_process	response to molecule of bacterial origin
p	0002376	biological_process	immune system process
p	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
p	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
p	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
p	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
p	0002726	biological_process	positive regulation of T cell cytokine production
p	0005198	molecular_function	structural molecule activity
p	0005515	molecular_function	protein binding
p	0005576	cellular_component	extracellular region
p	0005615	cellular_component	extracellular space
p	0005765	cellular_component	lysosomal membrane
p	0005783	cellular_component	endoplasmic reticulum
p	0005788	cellular_component	endoplasmic reticulum lumen
p	0005794	cellular_component	Golgi apparatus
p	0005829	cellular_component	cytosol
p	0005886	cellular_component	plasma membrane
p	0005925	cellular_component	focal adhesion
p	0006826	biological_process	iron ion transport
p	0006879	biological_process	intracellular iron ion homeostasis
p	0006955	biological_process	immune response
p	0007608	biological_process	sensory perception of smell
p	0007611	biological_process	learning or memory
p	0009897	cellular_component	external side of plasma membrane
p	0009986	cellular_component	cell surface
p	0010038	biological_process	response to metal ion
p	0010977	biological_process	negative regulation of neuron projection development
p	0012507	cellular_component	ER to Golgi transport vesicle membrane
p	0016020	cellular_component	membrane
p	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
p	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
p	0023026	molecular_function	MHC class II protein complex binding
p	0030670	cellular_component	phagocytic vesicle membrane
p	0031901	cellular_component	early endosome membrane
p	0031902	cellular_component	late endosome membrane
p	0031905	cellular_component	early endosome lumen
p	0033077	biological_process	T cell differentiation in thymus
p	0033572	biological_process	transferrin transport
p	0034756	biological_process	regulation of iron ion transport
p	0034757	biological_process	negative regulation of iron ion transport
p	0035580	cellular_component	specific granule lumen
p	0042026	biological_process	protein refolding
p	0042605	molecular_function	peptide antigen binding
p	0042612	cellular_component	MHC class I protein complex
p	0042613	cellular_component	MHC class II protein complex
p	0042802	molecular_function	identical protein binding
p	0042803	molecular_function	protein homodimerization activity
p	0042824	cellular_component	MHC class I peptide loading complex
p	0045646	biological_process	regulation of erythrocyte differentiation
p	0048260	biological_process	positive regulation of receptor-mediated endocytosis
p	0048261	biological_process	negative regulation of receptor-mediated endocytosis
p	0050680	biological_process	negative regulation of epithelial cell proliferation
p	0050768	biological_process	negative regulation of neurogenesis
p	0050778	biological_process	positive regulation of immune response
p	0050870	biological_process	positive regulation of T cell activation
p	0051289	biological_process	protein homotetramerization
p	0055038	cellular_component	recycling endosome membrane
p	0060586	biological_process	multicellular organismal-level iron ion homeostasis
p	0070062	cellular_component	extracellular exosome
p	0071281	biological_process	cellular response to iron ion
p	0071283	biological_process	cellular response to iron(III) ion
p	0071316	biological_process	cellular response to nicotine
p	1904724	cellular_component	tertiary granule lumen
p	1990000	biological_process	amyloid fibril formation
p	1990712	cellular_component	HFE-transferrin receptor complex
p	2000774	biological_process	positive regulation of cellular senescence
p	2000978	biological_process	negative regulation of forebrain neuron differentiation
u	0000139	cellular_component	Golgi membrane
u	0001913	biological_process	T cell mediated cytotoxicity
u	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
u	0002237	biological_process	response to molecule of bacterial origin
u	0002376	biological_process	immune system process
u	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
u	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
u	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
u	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
u	0002726	biological_process	positive regulation of T cell cytokine production
u	0005198	molecular_function	structural molecule activity
u	0005515	molecular_function	protein binding
u	0005576	cellular_component	extracellular region
u	0005615	cellular_component	extracellular space
u	0005765	cellular_component	lysosomal membrane
u	0005783	cellular_component	endoplasmic reticulum
u	0005788	cellular_component	endoplasmic reticulum lumen
u	0005794	cellular_component	Golgi apparatus
u	0005829	cellular_component	cytosol
u	0005886	cellular_component	plasma membrane
u	0005925	cellular_component	focal adhesion
u	0006826	biological_process	iron ion transport
u	0006879	biological_process	intracellular iron ion homeostasis
u	0006955	biological_process	immune response
u	0007608	biological_process	sensory perception of smell
u	0007611	biological_process	learning or memory
u	0009897	cellular_component	external side of plasma membrane
u	0009986	cellular_component	cell surface
u	0010038	biological_process	response to metal ion
u	0010977	biological_process	negative regulation of neuron projection development
u	0012507	cellular_component	ER to Golgi transport vesicle membrane
u	0016020	cellular_component	membrane
u	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
u	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
u	0023026	molecular_function	MHC class II protein complex binding
u	0030670	cellular_component	phagocytic vesicle membrane
u	0031901	cellular_component	early endosome membrane
u	0031902	cellular_component	late endosome membrane
u	0031905	cellular_component	early endosome lumen
u	0033077	biological_process	T cell differentiation in thymus
u	0033572	biological_process	transferrin transport
u	0034756	biological_process	regulation of iron ion transport
u	0034757	biological_process	negative regulation of iron ion transport
u	0035580	cellular_component	specific granule lumen
u	0042026	biological_process	protein refolding
u	0042605	molecular_function	peptide antigen binding
u	0042612	cellular_component	MHC class I protein complex
u	0042613	cellular_component	MHC class II protein complex
u	0042802	molecular_function	identical protein binding
u	0042803	molecular_function	protein homodimerization activity
u	0042824	cellular_component	MHC class I peptide loading complex
u	0045646	biological_process	regulation of erythrocyte differentiation
u	0048260	biological_process	positive regulation of receptor-mediated endocytosis
u	0048261	biological_process	negative regulation of receptor-mediated endocytosis
u	0050680	biological_process	negative regulation of epithelial cell proliferation
u	0050768	biological_process	negative regulation of neurogenesis
u	0050778	biological_process	positive regulation of immune response
u	0050870	biological_process	positive regulation of T cell activation
u	0051289	biological_process	protein homotetramerization
u	0055038	cellular_component	recycling endosome membrane
u	0060586	biological_process	multicellular organismal-level iron ion homeostasis
u	0070062	cellular_component	extracellular exosome
u	0071281	biological_process	cellular response to iron ion
u	0071283	biological_process	cellular response to iron(III) ion
u	0071316	biological_process	cellular response to nicotine
u	1904724	cellular_component	tertiary granule lumen
u	1990000	biological_process	amyloid fibril formation
u	1990712	cellular_component	HFE-transferrin receptor complex
u	2000774	biological_process	positive regulation of cellular senescence
u	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
a	TYR78-HIS84

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140, ECO:0000305|PubMed:34380736, ECO:0000305|PubMed:35522713

Chain	Residue	Details
C	GLY3
v	GLY3
H	GLY3
M	GLY3
R	GLY3
W	GLY3
b	GLY3
g	GLY3
l	GLY3
q	GLY3

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	ILE1
u	ILE1
G	ILE1
L	ILE1
Q	ILE1
V	ILE1
a	ILE1
f	ILE1
k	ILE1
p	ILE1

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443

Chain	Residue	Details
B	LYS19
G	LYS58
G	LYS91
G	LYS94
L	LYS19
L	LYS41
L	LYS48
L	LYS58
L	LYS91
L	LYS94
Q	LYS19
B	LYS41
Q	LYS41
Q	LYS48
Q	LYS58
Q	LYS91
Q	LYS94
V	LYS19
V	LYS41
V	LYS48
V	LYS58
V	LYS91
B	LYS48
V	LYS94
a	LYS19
a	LYS41
a	LYS48
a	LYS58
a	LYS91
a	LYS94
f	LYS19
f	LYS41
f	LYS48
B	LYS58
f	LYS58
f	LYS91
f	LYS94
k	LYS19
k	LYS41
k	LYS48
k	LYS58
k	LYS91
k	LYS94
p	LYS19
B	LYS91
p	LYS41
p	LYS48
p	LYS58
p	LYS91
p	LYS94
u	LYS19
u	LYS41
u	LYS48
u	LYS58
u	LYS91
B	LYS94
u	LYS94
G	LYS19
G	LYS41
G	LYS48

---