8I0L
Structure of CDK9/cyclin T1 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 9 | polymer | 332 | 38199.3 | 1 | UniProt (P50750) Pfam (PF00069) In PDB | Homo sapiens (human) | C-2K,Cell division cycle 2-like protein kinase 4,Cell division protein kinase 9,Serine/threonine-protein kinase PITALRE,Tat-associated kinase complex catalytic subunit |
| 2 | B | Cyclin-T1 | polymer | 259 | 30062.4 | 1 | UniProt (O60563) Pfam (PF00134) Pfam (PF21797) In PDB | Homo sapiens (human) | CycT1,Cyclin-T |
| 3 | A | 2-[(4-azanylcyclohexyl)amino]-7-cyclopentyl-~{N},~{N}-dimethyl-pyrrolo[2,3-d]pyrimidine-6-carboxamide | non-polymer | 370.5 | 1 | Chemie (NJ6) |
Sequence modifications
A: 2 - 330 (UniProt: P50750)
B: 2 - 259 (UniProt: O60563)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Ala 97 | Gly 97 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Pro 1 | - | expression tag |
| Arg 77 | Gln 77 | conflict |
| Gly 96 | Glu 96 | conflict |
| Leu 241 | Phe 241 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68261.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 370.5 | |
| All* | Total formula weight | 68632.2 |
