8HY7
EGFR kinase domain mutant "TMLR" with compound 28f
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 330 | 37492.3 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | A | ~{N}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide | non-polymer | 497.6 | 1 | Chemie (NSO) | |||
| 3 | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | variant |
| Arg 858 | Leu 858 | variant |
| Ala 865 | Glu 865 | engineered mutation |
| Ala 866 | Glu 866 | engineered mutation |
| Ala 867 | Lys 867 | engineered mutation |
| Asn 1023 | - | expression tag |
| Ser 1024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37492.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 497.6 | |
| All* | Total formula weight | 37989.9 |
