8HUQ
X-ray structure of human PPAR alpha ligand binding domain-elafibranor-SRC1 coactivator peptide co-crystals obtained by soaking
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Peroxisome proliferator-activated receptor alpha | polymer | 273 | 30856.1 | 1 | UniProt (Q07869) Pfam (PF00104) In PDB | Homo sapiens (human) | |
| 2 | B | 15-meric peptide from Nuclear receptor coactivator 1 | polymer | 15 | 1848.2 | 1 | UniProt (Q15788) In PDB | Homo sapiens | |
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | 2-[2,6-dimethyl-4-[(~{E})-3-(4-methylsulfanylphenyl)-3-oxidanylidene-prop-1-enyl]phenoxy]-2-methyl-propanoic acid | non-polymer | 384.5 | 1 | Chemie (MUO) | |||
| 5 | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A: 200 - 468 (UniProt: Q07869)
| PDB | External Database | Details |
|---|---|---|
| Gly 196 | - | expression tag |
| Ser 197 | - | expression tag |
| His 198 | - | expression tag |
| Met 199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 32704.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 476.6 | |
| All* | Total formula weight | 33180.8 |
