8HUG
F1 in complex with CRM1-Ran-RanBP1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTP-binding nuclear protein Ran | polymer | 216 | 24399.1 | 1 | UniProt (P62826) Pfam (PF00071) In PDB | Homo sapiens (human) | Androgen receptor-associated protein 24,GTPase Ran,Ras-like protein TC4,Ras-related nuclear protein |
2 | B | YRB1 isoform 1 | polymer | 140 | 16320.7 | 1 | UniProt (A0A6A5PZB5) Pfam (PF00638) UniProt (by SIFTS) (P41920) In PDB | Saccharomyces cerevisiae (baker's yeast) | |
3 | C | CRM1 isoform 1 | polymer | 1003 | 115224.5 | 1 | UniProt (A0A6A5PZI8) Pfam (PF03810) Pfam (PF08389) Pfam (PF18777) Pfam (PF18784) Pfam (PF18787) Pfam (PF08767) UniProt (by SIFTS) (P30822) In PDB | Saccharomyces cerevisiae (baker's yeast) | HLJ1_G0022020.mRNA.1.CDS.1,Y55_G0022260.mRNA.1.CDS.1 |
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | A, C | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
6 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
7 | C | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
8 | C | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
9 | C | 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid | non-polymer | 489.9 | 1 | Chemie (N59) | |||
10 | water | water | 18.0 | 591 | Chemie (HOH) |
Sequence modifications
A: 1 - 216 (UniProt: P62826)
C: 1 - 1058 (UniProt: A0A6A5PZI8)
PDB | External Database | Details |
---|---|---|
Leu 69 | Gln 69 | engineered mutation |
Ala 182 | Leu 182 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Glu 27 | Ser 27 | engineered mutation |
Glu 49 | Gln 49 | engineered mutation |
Val 51 | Ala 51 | engineered mutation |
- | Val 377 | deletion |
- | Gln 378 | deletion |
- | Arg 379 | deletion |
- | Leu 380 | deletion |
- | Pro 381 | deletion |
- | Ala 382 | deletion |
- | Thr 383 | deletion |
- | Glu 384 | deletion |
- | Met 385 | deletion |
- | Ser 386 | deletion |
- | Pro 387 | deletion |
- | Leu 388 | deletion |
- | Ile 389 | deletion |
- | Gln 390 | deletion |
- | Leu 391 | deletion |
- | Ser 392 | deletion |
- | Val 393 | deletion |
- | Gly 394 | deletion |
- | Ser 395 | deletion |
- | Gln 396 | deletion |
- | Ala 397 | deletion |
- | Ile 398 | deletion |
- | Ser 399 | deletion |
- | Thr 400 | deletion |
- | Gly 401 | deletion |
- | Ser 402 | deletion |
- | Gly 403 | deletion |
- | Ala 404 | deletion |
- | Leu 405 | deletion |
- | Asn 406 | deletion |
- | Pro 407 | deletion |
- | Glu 408 | deletion |
- | Tyr 409 | deletion |
- | Met 410 | deletion |
- | Lys 411 | deletion |
- | Arg 412 | deletion |
- | Phe 413 | deletion |
- | Val 441 | deletion |
- | Leu 442 | deletion |
- | Val 443 | deletion |
- | Val 444 | deletion |
- | Glu 445 | deletion |
- | Asn 446 | deletion |
- | Asp 447 | deletion |
- | Glu 448 | deletion |
- | Gly 449 | deletion |
- | Glu 450 | deletion |
- | Ile 451 | deletion |
- | Val 452 | deletion |
- | Arg 453 | deletion |
- | Glu 454 | deletion |
- | Phe 455 | deletion |
- | Val 456 | deletion |
- | Lys 457 | deletion |
- | Glu 458 | deletion |
- | Ser 459 | deletion |
- | Asp 460 | deletion |
- | Thr 461 | deletion |
Gly 537 | Asp 537 | engineered mutation |
Cys 539 | Thr 539 | engineered mutation |
Glu 540 | Val 540 | engineered mutation |
Gln 541 | Lys 541 | engineered mutation |
Arg 553 | Ser 553 | engineered mutation |
Glu 561 | Gln 561 | engineered mutation |
Thr 741 | Ala 741 | engineered mutation |
Cys 1022 | Tyr 1022 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 155944.2 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1746.6 | |
All* | Total formula weight | 157690.8 |