8HRZ

Crystal structure of the p97-N/D1 hexamer in complex with six p47-UBX domains

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Transitional endoplasmic reticulum ATPase	polymer	438	48904.1	12	UniProt (P55072) Pfam (PF02359) Pfam (PF02933) Pfam (PF00004) Pfam (PF17862)	Homo sapiens (human)	TER ATPase,15S Mg(2+)-ATPase p97 subunit,Valosin-containing protein,VCP
2	M, N, O, P, Q... (M, N, O, P, Q...)	NSFL1 cofactor p47	polymer	85	9575.0	12	UniProt (Q9UNZ2) Pfam (PF00789)	Homo sapiens (human)	UBX domain-containing protein 2C,p97 cofactor p47
3	AA, BA, CA, DA, EA... (C, D, E, F, G...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	12	Chemie (ADP)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 21 - 458 (UniProt: P55072)

PDB	External Database	Details
Ala 294	Glu 294	engineered mutation
Ala 295	Lys 295	engineered mutation

M, N, O, P, Q, R, S, T, U, V, W, X: 287 - 370 (UniProt: Q9UNZ2)

PDB	External Database	Details
Met 286	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	24
	Total formula weight	701749.7
Non-Polymers*	Number of molecules	12
	Total formula weight	5126.4
All*	Total formula weight	706876.1

*Water molecules are not included.