8HRY

Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Sodium/bile acid cotransporter	polymer	343	38198.9	1	UniProt (Q14973) Pfam (PF01758)	Homo sapiens (human)
2	B (B)	Large S protein (Fragment)	polymer	55	6229.6	1	UniProt (W5UNL7) UniProt (by SIFTS) (Q67926)	Hepatitis B virus
3	C (H)	Fab heavy chain from antibody IgG clone number YN9016	polymer	236	25306.5	1		Ondatra zibethicus
4	D (L)	Fab light chain from antibody IgG clone number YN9016	polymer	214	23667.1	1		Ondatra zibethicus

Sequence modifications

A: 1 - 319 (UniProt: Q14973)

PDB	External Database	Details
Ile 320	-	expression tag
Glu 321	-	expression tag
Asn 322	-	expression tag
Leu 323	-	expression tag
Tyr 324	-	expression tag
Phe 325	-	expression tag
Gln 326	-	expression tag
Gly 327	-	expression tag
Asp 328	-	expression tag
Tyr 329	-	expression tag
Lys 330	-	expression tag
Asp 331	-	expression tag
Asp 332	-	expression tag
Asp 333	-	expression tag
Asp 334	-	expression tag
Lys 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag

B: 2 - 48 (UniProt: W5UNL7)

PDB	External Database	Details
Asp 49	-	expression tag
Tyr 50	-	expression tag
Lys 51	-	expression tag
Asp 52	-	expression tag
Asp 53	-	expression tag
Asp 54	-	expression tag
Asp 55	-	expression tag
Lys 56	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	93402.1
All*	Total formula weight	93402.1

*Water molecules are not included.