8HRY
Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001618 | molecular_function | virus receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006869 | biological_process | lipid transport |
| A | 0008508 | molecular_function | bile acid:sodium symporter activity |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0031667 | biological_process | response to nutrient levels |
| A | 0043627 | biological_process | response to estrogen |
| A | 0045471 | biological_process | response to ethanol |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071466 | biological_process | cellular response to xenobiotic stimulus |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | MET1-PRO22 | |
| A | ARG84-LYS86 | |
| A | ARG143-TYR156 | |
| A | MET218-THR219 | |
| A | PHE274-GLY280 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | THR23-CYS44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | THR45-GLU47 | |
| A | LYS113-ASP115 | |
| A | ARG180-TYR183 | |
| A | PHE244-ASN247 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | PHE48-PHE83 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 25 |
| Details | TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | ASN87-MET112 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | MET116-SER142 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | LYS157-LYS179 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 33 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | MET184-ALA217 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | PRO220-LEU243 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 25 |
| Details | TRANSMEM: Discontinuously helical; Name=8 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | GLY248-ALA273 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:35545671, ECO:0000269|PubMed:35580629, ECO:0000269|PubMed:35580630, ECO:0000269|PubMed:38233573, ECO:0007744|PDB:7FCI, ECO:0007744|PDB:7PQG, ECO:0007744|PDB:7PQQ, ECO:0007744|PDB:7VAD, ECO:0007744|PDB:7VAG, ECO:0007744|PDB:7WSI, ECO:0007744|PDB:8HRX, ECO:0007744|PDB:8HRY |
| Chain | Residue | Details |
| A | PRO281-LYS311 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN5 | |
| A | ASN11 |
