8HND
Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Solute carrier organic anion transporter family member 1B1 | polymer | 724 | 80330.3 | 1 | UniProt (Q9Y6L6) Pfam (PF03137) Pfam (PF07648) | Homo sapiens (human) | SLCO1B1,Liver-specific organic anion transporter 1,LST-1,OATP-C,Organic anion transporter SLC21A6,Sodium-independent organic anion-transporting polypeptide 2,OATP-2,Solute carrier family 21 member 6 |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | C (A) | estrone 3-sulfate | non-polymer | 350.4 | 1 | Chemie (FY5) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
A: 1 - 691 (UniProt: Q9Y6L6)
| PDB | External Database | Details |
|---|---|---|
| Leu 692 | - | expression tag |
| Glu 693 | - | expression tag |
| Gly 694 | - | expression tag |
| Ser 695 | - | expression tag |
| Asp 696 | - | expression tag |
| Glu 697 | - | expression tag |
| Val 698 | - | expression tag |
| Asp 699 | - | expression tag |
| Ala 700 | - | expression tag |
| Gly 701 | - | expression tag |
| Ser 702 | - | expression tag |
| His 703 | - | expression tag |
| His 704 | - | expression tag |
| His 705 | - | expression tag |
| His 706 | - | expression tag |
| His 707 | - | expression tag |
| His 708 | - | expression tag |
| His 709 | - | expression tag |
| His 710 | - | expression tag |
| His 711 | - | expression tag |
| His 712 | - | expression tag |
| Gly 713 | - | expression tag |
| Ser 714 | - | expression tag |
| Val 715 | - | expression tag |
| Glu 716 | - | expression tag |
| Asp 717 | - | expression tag |
| Tyr 718 | - | expression tag |
| Lys 719 | - | expression tag |
| Asp 720 | - | expression tag |
| Asp 721 | - | expression tag |
| Asp 722 | - | expression tag |
| Asp 723 | - | expression tag |
| Lys 724 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 80330.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 571.6 | |
| All* | Total formula weight | 81326.4 |
