8HND
Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006869 | biological_process | lipid transport |
| A | 0008514 | molecular_function | organic anion transmembrane transporter activity |
| A | 0009925 | cellular_component | basal plasma membrane |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015132 | molecular_function | prostaglandin transmembrane transporter activity |
| A | 0015347 | molecular_function | sodium-independent organic anion transmembrane transporter activity |
| A | 0015349 | molecular_function | thyroid hormone transmembrane transporter activity |
| A | 0015711 | biological_process | organic anion transport |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015732 | biological_process | prostaglandin transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042167 | biological_process | heme catabolic process |
| A | 0043252 | biological_process | sodium-independent organic anion transport |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070327 | biological_process | thyroid hormone transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 154 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-LYS28 | |
| A | SER89-PRO94 | |
| A | ASP198-ALA216 | |
| A | GLN281-SER331 | |
| A | LYS398-LYS401 | |
| A | LYS561-SER569 | |
| A | LYS648-CYS691 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET29-MET48 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 246 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS49-GLY67 | |
| A | TYR120-SER168 | |
| A | GLY238-VAL255 | |
| A | GLY354-LYS373 | |
| A | PHE426-PHE537 | |
| A | ASP596-SER629 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE68-GLY88 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS95-GLY119 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR169-ASP197 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET217-ILE237 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY256-PRO280 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE332-ILE353 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA374-ILE397 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU402-TYR425 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL538-VAL560 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU570-ILE595 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000255 |
| Chain | Residue | Details |
| A | SER630-MET647 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER293 | |
| A | SER295 | |
| A | SER672 | |
| A | SER682 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN130 | |
| A | ASN432 | |
| A | ASN617 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23285087 |
| Chain | Residue | Details |
| A | ASN134 | |
| A | ASN503 | |
| A | ASN516 |
