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8HLR

Human ADP-ribosyltransferase 1 (PARP1) catalytic domain bound to Fluzoparib (SHR3162)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BPoly [ADP-ribose] polymerase 1, processed C-terminuspolymer35439555.32UniProt (P09874)
Pfam (PF02877)
Pfam (PF00644)
In PDB
Homo sapiens (Human)Poly [ADP-ribose] polymerase 1,89-kDa form
2A, BFluzoparibnon-polymer472.42Chemie (25I)
3A, BSULFATE IONnon-polymer96.112Chemie (SO4)
4waterwater18.032Chemie (HOH)
Sequence modifications
A, B: 662 - 1011 (UniProt: P09874)
PDBExternal DatabaseDetails
Gly 658-expression tag
Pro 659-expression tag
Met 660-expression tag
Thr 661-expression tag
Ala 762Val 762variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight79110.5
Non-Polymers*Number of molecules14
Total formula weight2097.5
All*Total formula weight81208.1
*Water molecules are not included.

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PDB entries from 2024-06-12

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