8HLA

Heteromeric ring comprised of peroxiredoxin from Thermococcus kodakaraensis (TkPrx) F42C/C46S/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrx*F42C) and TkPrx C46S/F76C/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrx*F76C) (Naph@(MIX|3:3))

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F, I...	Peroxiredoxin	polymer	216	24585.1	6	UniProt (Q5JF30) Pfam (PF00578) Pfam (PF10417) In PDB	Thermococcus kodakarensis KOD1	Thioredoxin peroxidase,Thioredoxin-dependent peroxiredoxin
2	C, D, G, H, K...	Peroxiredoxin	polymer	216	24585.1	6	UniProt (Q5JF30) Pfam (PF00578) Pfam (PF10417) In PDB	Thermococcus kodakarensis KOD1	Thioredoxin peroxidase,Thioredoxin-dependent peroxiredoxin
3	B, C, D, E, H...	1-naphthalen-2-ylethanone	non-polymer		170.2	12	Chemie (FL3)

Sequence modifications

A, B, E, F, I, J: 1 - 216 (UniProt: Q5JF30)

PDB	External Database	Details
Ser 46	Cys 46	engineered mutation
Cys 76	Phe 76	engineered mutation
Ser 205	Cys 205	engineered mutation
Ser 211	Cys 211	engineered mutation

C, D, G, H, K, L: 1 - 216 (UniProt: Q5JF30)

PDB	External Database	Details
Cys 42	Phe 42	engineered mutation
Ser 46	Cys 46	engineered mutation
Ser 205	Cys 205	engineered mutation
Ser 211	Cys 211	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	295021.7
Non-Polymers*	Number of molecules	12
	Total formula weight	2042.5
All*	Total formula weight	297064.2

*Water molecules are not included.