Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HLA

Heteromeric ring comprised of peroxiredoxin from Thermococcus kodakaraensis (TkPrx) F42C/C46S/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrxF42C) and TkPrx C46S/F76C/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrxF76C) (Naph@(MIX|3:3))

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	0004601	molecular_function	peroxidase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0045454	biological_process	cell redox homeostasis
F	0051920	molecular_function	peroxiredoxin activity
F	0098869	biological_process	cellular oxidant detoxification
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	0004601	molecular_function	peroxidase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0045454	biological_process	cell redox homeostasis
G	0051920	molecular_function	peroxiredoxin activity
G	0098869	biological_process	cellular oxidant detoxification
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	0004601	molecular_function	peroxidase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0045454	biological_process	cell redox homeostasis
H	0051920	molecular_function	peroxiredoxin activity
H	0098869	biological_process	cellular oxidant detoxification
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	0004601	molecular_function	peroxidase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0045454	biological_process	cell redox homeostasis
I	0051920	molecular_function	peroxiredoxin activity
I	0098869	biological_process	cellular oxidant detoxification
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	0004601	molecular_function	peroxidase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0045454	biological_process	cell redox homeostasis
J	0051920	molecular_function	peroxiredoxin activity
J	0098869	biological_process	cellular oxidant detoxification
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
K	0004601	molecular_function	peroxidase activity
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0016209	molecular_function	antioxidant activity
K	0016491	molecular_function	oxidoreductase activity
K	0045454	biological_process	cell redox homeostasis
K	0051920	molecular_function	peroxiredoxin activity
K	0098869	biological_process	cellular oxidant detoxification
K	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
L	0004601	molecular_function	peroxidase activity
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0016209	molecular_function	antioxidant activity
L	0016491	molecular_function	oxidoreductase activity
L	0045454	biological_process	cell redox homeostasis
L	0051920	molecular_function	peroxiredoxin activity
L	0098869	biological_process	cellular oxidant detoxification
L	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1872
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"HAMAP-Rule","id":"MF_00401","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_00401","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00401","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)

8HLA

Heteromeric ring comprised of peroxiredoxin from Thermococcus kodakaraensis (TkPrx) F42C/C46S/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrx*F42C) and TkPrx C46S/F76C/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrx*F76C) (Naph@(MIX|3:3))

Heteromeric ring comprised of peroxiredoxin from Thermococcus kodakaraensis (TkPrx) F42C/C46S/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrxF42C) and TkPrx C46S/F76C/C205S/C211S mutant modified with 2-(bromoacetyl)naphthalene (Naph@TkPrxF76C) (Naph@(MIX|3:3))