8HL7
Crystal structure of p97 N/D1 in complex with a valosin-containing protein methyltransferase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein N-lysine methyltransferase METTL21D | polymer | 208 | 23501.0 | 1 | UniProt (Q9H867) Pfam (PF10294) | Homo sapiens (human) | Methyltransferase-like protein 21D |
| 2 | B (B) | Transitional endoplasmic reticulum ATPase | polymer | 436 | 48791.0 | 1 | UniProt (P55072) Pfam (PF02359) Pfam (PF02933) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | TER ATPase,15S Mg(2+)-ATPase p97 subunit,Valosin-containing protein,VCP |
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | D, E, J (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | F, I (A, B) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 6 | G (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 7 | H (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 8 | K (B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 9 | L, M (A, B) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 16 - 222 (UniProt: Q9H867)
| PDB | External Database | Details |
|---|---|---|
| Met 15 | - | initiating methionine |
| Val 130 | Ile 130 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72292.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1477.3 | |
| All* | Total formula weight | 73769.3 |
