8HL7
Crystal structure of p97 N/D1 in complex with a valosin-containing protein methyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0018022 | biological_process | peptidyl-lysine methylation |
| A | 0018023 | biological_process | peptidyl-lysine trimethylation |
| A | 0032259 | biological_process | methylation |
| A | 0032780 | biological_process | negative regulation of ATP-dependent activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0051117 | molecular_function | ATPase binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PROSITE/UniProt
| site_id | PS00674 |
| Number of Residues | 19 |
| Details | AAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R |
| Chain | Residue | Details |
| B | VAL341-ARG359 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20512113 |
| Chain | Residue | Details |
| B | PRO247 | |
| B | ASN348 | |
| B | HIS384 | |
| A | TRP126 | |
| A | ALA143 | |
| A | TYR148 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| B | SER37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine; by VCPKMT => ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:23349634 |
| Chain | Residue | Details |
| B | M3L315 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| B | THR436 |
