8HKS
Mutated human ADP-ribosyltransferase 2 (PARP2) catalytic domain bound to Pamiparib(BGB-290)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Poly [ADP-ribose] polymerase 2 | polymer | 353 | 39965.9 | 4 | UniProt (Q9UGN5) Pfam (PF02877) Pfam (PF00644) In PDB | Homo sapiens (human) | PARP-2,hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,DNA ADP-ribosyltransferase PARP2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2,Protein poly-ADP-ribosyltransferase PARP2 |
2 | A, B, C, D | GLYCEROL | non-polymer | 92.1 | 12 | Chemie (GOL) | |||
3 | A, B, C, D | (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one | non-polymer | 298.3 | 4 | Chemie (DS9) | |||
4 | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 230 - 581 (UniProt: Q9UGN5)
PDB | External Database | Details |
---|---|---|
Gly 229 | - | expression tag |
Ser 349 | Thr 349 | engineered mutation |
Arg 351 | Leu 351 | engineered mutation |
Gly 353 | Ser 353 | engineered mutation |
Leu 354 | Pro 354 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 159863.6 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 2298.4 | |
All* | Total formula weight | 162162.0 |