8HG7
Structure of human SGLT2-MAP17 complex with Sotagliflozin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Sodium/glucose cotransporter 2 | polymer | 676 | 73247.7 | 1 | UniProt (P31639) Pfam (PF00474) In PDB | Homo sapiens (human) | Na(+)/glucose cotransporter 2,Low affinity sodium-glucose cotransporter,Solute carrier family 5 member 2 |
| 2 | B | PDZK1-interacting protein 1 | polymer | 114 | 12235.0 | 1 | UniProt (Q13113) Pfam (PF15807) In PDB | Homo sapiens (human) | 17 kDa membrane-associated protein |
| 3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 4 | A | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol | non-polymer | 424.9 | 1 | Chemie (LFL) | |||
| 5 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 1 - 672 (UniProt: P31639)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 85482.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 669.1 | |
| All* | Total formula weight | 86151.8 |
