Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8HG7

Structure of human SGLT2-MAP17 complex with Sotagliflozin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000017	biological_process	alpha-glucoside transport
A	0005362	molecular_function	low-affinity D-glucose:sodium symporter activity
A	0005412	molecular_function	D-glucose:sodium symporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0008645	biological_process	hexose transmembrane transport
A	0015151	molecular_function	alpha-glucoside transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015370	molecular_function	solute:sodium symporter activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0035623	biological_process	renal D-glucose absorption
A	0046872	molecular_function	metal ion binding
A	0055056	molecular_function	D-glucose transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0098708	biological_process	D-glucose import across plasma membrane
A	0098719	biological_process	sodium ion import across plasma membrane
A	1904659	biological_process	D-glucose transmembrane transport
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00456
Number of Residues	26
Details	NA_SOLUT_SYMP_1 Sodium:solute symporter family signature 1. GwnIyasVIALLGItmiYTvtGGLaA

Chain	Residue	Details
A	GLY171-ALA196

site_id	PS00457
Number of Residues	21
Details	NA_SOLUT_SYMP_2 Sodium:solute symporter family signature 2. ALfvpRvneqGAfwGLIGGlL

Chain	Residue	Details
A	ALA474-LEU494

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
B	MET1-GLN28
A	GLY86-LEU93
A	GLN167-ASN173
A	TYR218-PRO275
A	GLY332-PRO375
A	ALA447-GLN451
A	PHE506-GLY523
A	TYR671-ALA672

site_id	SWS_FT_FI2
Number of Residues	22
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
B	PRO29-ASN51

site_id	SWS_FT_FI3
Number of Residues	62
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
B	HIS52-MET114
A	PRO115-ARG136
A	MET407-LEU424
A	PRO478-GLU482
A	THR548-ARG651

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q9CQH0

Chain	Residue	Details
B	SER85

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=TM2 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	ALA94-ALA114

site_id	SWS_FT_FI6
Number of Residues	29
Details	TRANSMEM: Helical; Name=TM3 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	ARG137-ILE166

site_id	SWS_FT_FI7
Number of Residues	21
Details	TRANSMEM: Helical; Name=TM4 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	ILE174-ALA195

site_id	SWS_FT_FI8
Number of Residues	21
Details	TRANSMEM: Helical; Name=TM5 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	ALA196-GLY217

site_id	SWS_FT_FI9
Number of Residues	19
Details	TRANSMEM: Helical; Name=TM6 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	TRP276-GLN295

site_id	SWS_FT_FI10
Number of Residues	13
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0000305, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	VAL296-HIS309

site_id	SWS_FT_FI11
Number of Residues	21
Details	TRANSMEM: Helical; Name=TM7 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	ILE310-PRO331

site_id	SWS_FT_FI12
Number of Residues	30
Details	TRANSMEM: Helical; Name=TM8 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	ASN376-THR406

site_id	SWS_FT_FI13
Number of Residues	21
Details	TRANSMEM: Helical; Name=TM9 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	VAL425-ALA446

site_id	SWS_FT_FI14
Number of Residues	25
Details	TRANSMEM: Helical; Name=TM10 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	LEU452-VAL477

site_id	SWS_FT_FI15
Number of Residues	22
Details	TRANSMEM: Helical; Name=TM11 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	GLN483-SER505

site_id	SWS_FT_FI16
Number of Residues	23
Details	TRANSMEM: Helical; Name=TM12 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	VAL524-CYS547

site_id	SWS_FT_FI17
Number of Residues	18
Details	TRANSMEM: Helical; Name=TM13 => ECO:0000269\|PubMed:34880493, ECO:0000269\|PubMed:37217492, ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:7VSI, ECO:0007744\|PDB:7YNJ, ECO:0007744\|PDB:7YNK, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7, ECO:0007744\|PDB:8HIN

Chain	Residue	Details
A	VAL652-PHE670

site_id	SWS_FT_FI18
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269\|PubMed:38057552, ECO:0007744\|PDB:8HB0, ECO:0007744\|PDB:8HDH, ECO:0007744\|PDB:8HEZ, ECO:0007744\|PDB:8HG7

Chain	Residue	Details
A	ALA73
A	ILE76
A	ALA389
A	SER392
A	SER393

site_id	SWS_FT_FI19
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN250

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)