8HE3
Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (delta 724-751)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Importin subunit alpha-1 | polymer | 428 | 46374.2 | 1 | UniProt (P52293) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) | Mus musculus (house mouse) | Importin alpha P1 |
| 2 | B (B) | Hypoxia-inducible factor 1-alpha | polymer | 15 | 1881.3 | 1 | UniProt (by SIFTS) (Q16665) | Homo sapiens (human) | |
| 3 | C, D, E, F, G... (A) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence modifications
A: 72 - 498 (UniProt: P52293)
| PDB | External Database | Details |
|---|---|---|
| Met 71 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48255.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 576.4 | |
| All* | Total formula weight | 48831.8 |
