8HE0
Crystal structure of importin-alpha1 bound to the HIF-1alpha nuclear localization signal (wild-type)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Importin subunit alpha-1 | polymer | 428 | 46374.2 | 1 | UniProt (P52293) Pfam (PF01749) Pfam (PF00514) Pfam (PF16186) | Mus musculus (house mouse) | Importin alpha P1,Karyopherin subunit alpha-2,Pendulin,Pore targeting complex 58 kDa subunit,PTAC58,RAG cohort protein 1,SRP1-alpha |
| 2 | B (B) | Hypoxia-inducible factor 1-alpha | polymer | 43 | 4745.4 | 1 | UniProt (Q16665) | Homo sapiens (human) | HIF-1-alpha,HIF1-alpha |
| 3 | C, D (A, B) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
A: 72 - 498 (UniProt: P52293)
B: 717 - 757 (UniProt: Q16665)
| PDB | External Database | Details |
|---|---|---|
| Met 71 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 715 | - | expression tag |
| Ser 716 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51119.5 | |
| All* | Total formula weight | 51119.5 |
