8HDO
Structure of A2BR bound to synthetic agonists BAY 60-6583
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chimeric miniGs | polymer | 246 | 29048.9 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (N) | Nanobody 35 | polymer | 128 | 13885.4 | 1 | Camelus bactrianus | ||
| 5 | E (R) | Adenosine A2b receptor | polymer | 332 | 36359.9 | 1 | UniProt (P29275) Pfam (PF00001) | Homo sapiens (human) | |
| 6 | F, G, H, I, J... (R) | CHOLESTEROL | non-polymer | 386.7 | 7 | Chemie (CLR) | |||
| 7 | M (R) | 2-[6-azanyl-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]pyridin-2-yl]sulfanylethanamide | non-polymer | 379.4 | 1 | Chemie (I5D) |
Sequence modifications
A: 1 - 66 (UniProt: P63092)
A: 67 - 115 (UniProt: P63092)
A: 116 - 246 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 25 | Lys 25 | conflict |
| Asp 49 | Gly 49 | conflict |
| Asn 50 | Glu 50 | conflict |
| Tyr 63 | Leu 63 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 88 | Gly 226 | conflict |
| Asp 111 | Ala 249 | conflict |
| Asp 114 | Ser 252 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 124 | Leu 272 | conflict |
| Ser 218 | Ala 366 | conflict |
| Ala 224 | Ile 372 | conflict |
| Ile 227 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 125070.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3086.0 | |
| All* | Total formula weight | 128156.9 |
