8HDG

Small peptide enhances the binding of nutline-3a to MdmX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (D, A, C, B)	Uncharacterized protein DKFZp686B01123	polymer	111	12734.6	4	UniProt (Q6MZR7) UniProt (by SIFTS) (O15151)	Homo sapiens (human)
2	E, G, I, J (D, A, C, B)	4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one	non-polymer		581.5	4	Chemie (NUT)
3	F, H, K, L (D, A, B)	1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE	non-polymer		264.3	4	Chemie (O4B)
4	M, N, O, P (D, A, C, B)	water	water		18.0	111	Chemie (HOH)

Sequence modifications

D, A, C, B: 23 - 111 (UniProt: Q6MZR7)

PDB	External Database	Details
Met 1	-	initiating methionine
Gly 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Ser 11	-	expression tag
Gln 12	-	expression tag
Asp 13	-	expression tag
Leu 14	-	expression tag
Glu 15	-	expression tag
Asn 16	-	expression tag
Leu 17	-	expression tag
Tyr 18	-	expression tag
Phe 19	-	expression tag
Gln 20	-	expression tag
Gly 21	-	expression tag
Ser 22	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	50938.5
Non-Polymers*	Number of molecules	8
	Total formula weight	3383.2
All*	Total formula weight	54321.7

*Water molecules are not included.