8HBM

Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Retinoic acid receptor RXR-alpha	polymer	91	10733.5	2	UniProt (P19793) Pfam (PF00105) In PDB	Homo sapiens (human)	Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha
2	B, F	Bile acid receptor	polymer	109	12446.8	2	UniProt (Q96RI1) Pfam (PF00105) In PDB	Homo sapiens (human)	Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
3	C, G	DNA (5'-D(P*CP*CP*GP*AP*GP*GP*TP*CP*AP*AP*TP*GP*AP*CP*CP*TP*CP*G)-3')	polymer	18	5501.6	2		Homo sapiens
4	D, H	DNA (5'-D(P*CP*CP*GP*AP*GP*GP*TP*CP*AP*TP*TP*GP*AP*CP*CP*TP*CP*G)-3')	polymer	18	5492.6	2		Homo sapiens
5	A, B, E, F	ZINC ION	non-polymer		65.4	8	Chemie (ZN)

Sequence modifications

A, E: 130 - 212 (UniProt: P19793)

PDB	External Database	Details
Leu 122	-	expression tag
Glu 123	-	expression tag
Val 124	-	expression tag
Leu 125	-	expression tag
Phe 126	-	expression tag
Gln 127	-	expression tag
Gly 128	-	expression tag
Pro 129	-	expression tag

B, F: 117 - 217 (UniProt: Q96RI1)

PDB	External Database	Details
Leu 109	-	expression tag
Glu 110	-	expression tag
Val 111	-	expression tag
Leu 112	-	expression tag
Phe 113	-	expression tag
Gln 114	-	expression tag
Gly 115	-	expression tag
Pro 116	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	68348.9
Non-Polymers*	Number of molecules	8
	Total formula weight	523.3
All*	Total formula weight	68872.1

*Water molecules are not included.