8HBM
Structural basis of the farnesoid X receptor/retinoid X receptor heterodimer on inverted repeat DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR |
| Chain | Residue | Details |
| A | CYS135-ARG161 | |
| B | CYS127-ARG153 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 150 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| B | ASP124-THR199 | |
| F | ASP124-THR199 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 88 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| B | CYS127-CYS147 | |
| B | CYS163-CYS187 | |
| F | CYS127-CYS147 | |
| F | CYS163-CYS187 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCA => ECO:0000269|PubMed:18755856 |
| Chain | Residue | Details |
| B | SER135 | |
| B | SER154 | |
| F | SER135 | |
| F | SER154 | |
| A | CYS171 | |
| A | CYS177 | |
| A | CYS187 | |
| A | CYS190 | |
| E | CYS135 | |
| E | CYS138 | |
| E | CYS152 | |
| E | CYS155 | |
| E | CYS171 | |
| E | CYS177 | |
| E | CYS187 | |
| E | CYS190 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; by EP300 |
| Chain | Residue | Details |
| B | LYS157 | |
| B | LYS217 | |
| F | LYS157 | |
| F | LYS217 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; by SETD7 => ECO:0000269|PubMed:22345554 |
| Chain | Residue | Details |
| B | LYS210 | |
| F | LYS210 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1) => ECO:0000305|PubMed:23546875 |
| Chain | Residue | Details |
| B | LYS122 | |
| F | LYS122 |
