8HAO
Human parathyroid hormone receptor-1 dimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Guanine nucleotide-binding protein G(s) subunit alpha | polymer | 361 | 41879.5 | 2 | Bos taurus (cattle) | ||
2 | B, D | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 400 | 43706.8 | 2 | Pfam (PF00400) UniProt (by SIFTS) (P54311) In PDB | Rattus norvegicus (rat) | |
3 | E, G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 2 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (cattle) | G gamma-I |
4 | F, N | Nanobody 35 | polymer | 140 | 15343.0 | 2 | synthetic construct | ||
5 | H, P | Parathyroid hormone | polymer | 35 | 4123.8 | 2 | UniProt (P01270) Pfam (PF01279) In PDB | Homo sapiens (human) | PTH,Parathormone,Parathyrin |
6 | I, R | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 476 | 54506.7 | 2 | UniProt (Q03431) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
Sequence modifications
H, P: 1 - 34 (UniProt: P01270)
I, R: 27 - 502 (UniProt: Q03431)
PDB | External Database | Details |
---|---|---|
Nh2 35 | - | amidation |
PDB | External Database | Details |
---|---|---|
Ala 188 | Gly 188 | conflict |
Arg 484 | Lys 484 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 334841.8 | |
All* | Total formula weight | 334841.8 |