8HAO

Human parathyroid hormone receptor-1 dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Guanine nucleotide-binding protein G(s) subunit alpha	polymer	361	41879.5	2		Bos taurus (cattle)
2	B, D (B, D)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	400	43706.8	2	Pfam (PF25391) UniProt (by SIFTS) (P54311)	Rattus norvegicus (rat)
3	E, G (E, G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	2	UniProt (P63212) Pfam (PF00631)	Bos taurus (cattle)	G gamma-I
4	F, J (F, N)	Nanobody 35	polymer	140	15343.0	2		synthetic construct
5	H, K (H, P)	Parathyroid hormone	polymer	35	4123.8	2	UniProt (P01270) Pfam (PF01279)	Homo sapiens (human)	PTH,Parathormone,Parathyrin
6	I, L (I, R)	Parathyroid hormone/parathyroid hormone-related peptide receptor	polymer	476	54506.7	2	UniProt (Q03431) Pfam (PF02793) Pfam (PF00002)	Homo sapiens (human)	PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor

Sequence modifications

H, P: 1 - 34 (UniProt: P01270)

PDB	External Database	Details
Nh2 35	-	amidation

I, R: 27 - 502 (UniProt: Q03431)

PDB	External Database	Details
Ala 188	Gly 188	conflict
Arg 484	Lys 484	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	334841.8
All*	Total formula weight	334841.8

*Water molecules are not included.