Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

8HAO

Human parathyroid hormone receptor-1 dimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0001917cellular_componentphotoreceptor inner segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008283biological_processcell population proliferation
B0010659biological_processcardiac muscle cell apoptotic process
B0030159molecular_functionsignaling receptor complex adaptor activity
B0030425cellular_componentdendrite
B0030507molecular_functionspectrin binding
B0042622cellular_componentphotoreceptor outer segment membrane
B0044297cellular_componentcell body
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0071456biological_processcellular response to hypoxia
C0003924molecular_functionGTPase activity
C0007186biological_processG protein-coupled receptor signaling pathway
C0019001molecular_functionguanyl nucleotide binding
C0031683molecular_functionG-protein beta/gamma-subunit complex binding
D0001750cellular_componentphotoreceptor outer segment
D0001917cellular_componentphotoreceptor inner segment
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008283biological_processcell population proliferation
D0010659biological_processcardiac muscle cell apoptotic process
D0030159molecular_functionsignaling receptor complex adaptor activity
D0030425cellular_componentdendrite
D0030507molecular_functionspectrin binding
D0042622cellular_componentphotoreceptor outer segment membrane
D0044297cellular_componentcell body
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0047391molecular_functionalkylglycerophosphoethanolamine phosphodiesterase activity
D0050909biological_processsensory perception of taste
D0051020molecular_functionGTPase binding
D0060041biological_processretina development in camera-type eye
D0071456biological_processcellular response to hypoxia
E0003924molecular_functionGTPase activity
E0005515molecular_functionprotein binding
E0005834cellular_componentheterotrimeric G-protein complex
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
E0016020cellular_componentmembrane
E0031681molecular_functionG-protein beta-subunit binding
E0071380biological_processcellular response to prostaglandin E stimulus
E0071870biological_processcellular response to catecholamine stimulus
G0003924molecular_functionGTPase activity
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
H0005179molecular_functionhormone activity
H0005576cellular_componentextracellular region
H0006874biological_processintracellular calcium ion homeostasis
I0004888molecular_functiontransmembrane signaling receptor activity
I0004930molecular_functionG protein-coupled receptor activity
I0004991molecular_functionparathyroid hormone receptor activity
I0007166biological_processcell surface receptor signaling pathway
I0007186biological_processG protein-coupled receptor signaling pathway
I0016020cellular_componentmembrane
P0005179molecular_functionhormone activity
P0005576cellular_componentextracellular region
P0006874biological_processintracellular calcium ion homeostasis
R0004888molecular_functiontransmembrane signaling receptor activity
R0004930molecular_functionG protein-coupled receptor activity
R0004991molecular_functionparathyroid hormone receptor activity
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00335
Number of Residues11
DetailsPARATHYROID Parathyroid hormone family signature. VSEiQlmHnlG
ChainResidueDetails
HVAL2-GLY12

site_idPS00649
Number of Residues25
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. ClpeWDhil.CWplGapgevvavpCP
ChainResidueDetails
ICYS108-PRO132

site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFFVaIIYCFcNgeV
ChainResidueDetails
IGLN451-VAL466

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
BVAL327-GLY341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
BSER2
DSER2
IARG343-TRP361
ITYR429-GLN440
RASP27-ALA188
RLYS240-ARG282
RARG343-TRP361
RTYR429-GLN440

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphohistidine => ECO:0000250|UniProtKB:P62871
ChainResidueDetails
BHIS266
DHIS266

site_idSWS_FT_FI3
Number of Residues90
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
IARG213-ARG219
IHIS307-TYR320
IARG383-SER409
RARG213-ARG219
RHIS307-TYR320
RARG383-SER409

site_idSWS_FT_FI4
Number of Residues38
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
IASN220-VAL239
RASN220-VAL239

site_idSWS_FT_FI5
Number of Residues46
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
IVAL283-LEU306
RVAL283-LEU306

site_idSWS_FT_FI6
Number of Residues42
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
ILEU321-VAL342
RLEU321-VAL342

site_idSWS_FT_FI7
Number of Residues40
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
IILE362-VAL382
RILE362-VAL382

site_idSWS_FT_FI8
Number of Residues36
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
ITHR410-PRO428
RTHR410-PRO428

site_idSWS_FT_FI9
Number of Residues44
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
IMET441-ASN463
RMET441-ASN463

site_idSWS_FT_FI10
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
IASN151
IASN161
IASN166
IASN176
RASN151
RASN161
RASN166
RASN176

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon