8HAF
PTHrP-PTH1R-Gs complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(s) subunit alpha-1 | polymer | 361 | 41879.5 | 1 | Bos taurus (cattle) | ||
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 400 | 43706.8 | 1 | UniProt (P54311) Pfam (PF00400) In PDB | Rattus norvegicus (rat) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P63212) Pfam (PF00631) In PDB | Bos taurus (cattle) | G gamma-I |
4 | N | Nanobody 35 | polymer | 140 | 15343.0 | 1 | synthetic construct | ||
5 | P | PTHrP[1-36] | polymer | 37 | 4267.9 | 1 | UniProt (P12272) Pfam (PF01279) In PDB | Homo sapiens (human) | |
6 | R | Parathyroid hormone/parathyroid hormone-related peptide receptor | polymer | 476 | 54506.7 | 1 | UniProt (Q03431) Pfam (PF02793) Pfam (PF00002) In PDB | Homo sapiens (human) | PTH/PTHrP type I receptor,PTH/PTHr receptor,Parathyroid hormone 1 receptor,PTH1 receptor |
7 | R | PALMITIC ACID | non-polymer | 256.4 | 11 | Chemie (PLM) | |||
8 | R | CHOLESTEROL | non-polymer | 386.7 | 6 | Chemie (CLR) |
Sequence modifications
B: 2 - 340 (UniProt: P54311)
P: 1 - 36 (UniProt: P12272)
R: 27 - 502 (UniProt: Q03431)
PDB | External Database | Details |
---|---|---|
Met -33 | - | expression tag |
His -32 | - | expression tag |
His -31 | - | expression tag |
His -30 | - | expression tag |
His -29 | - | expression tag |
His -28 | - | expression tag |
His -27 | - | expression tag |
Ser -26 | - | expression tag |
Ser -25 | - | expression tag |
Gly -24 | - | expression tag |
Leu -23 | - | expression tag |
Val -22 | - | expression tag |
Pro -21 | - | expression tag |
Arg -20 | - | expression tag |
Gly -19 | - | expression tag |
Ser -18 | - | expression tag |
His -17 | - | expression tag |
Met -16 | - | expression tag |
Ala -15 | - | expression tag |
Ser -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Gly 341 | - | expression tag |
Ser 342 | - | expression tag |
Ser 343 | - | expression tag |
Gly 344 | - | expression tag |
Gly 345 | - | expression tag |
Gly 346 | - | expression tag |
Gly 347 | - | expression tag |
Ser 348 | - | expression tag |
Gly 349 | - | expression tag |
Gly 350 | - | expression tag |
Gly 351 | - | expression tag |
Gly 352 | - | expression tag |
Ser 353 | - | expression tag |
Ser 354 | - | expression tag |
Gly 355 | - | expression tag |
Val 356 | - | expression tag |
Ser 357 | - | expression tag |
Gly 358 | - | expression tag |
Trp 359 | - | expression tag |
Arg 360 | - | expression tag |
Leu 361 | - | expression tag |
Phe 362 | - | expression tag |
Lys 363 | - | expression tag |
Lys 364 | - | expression tag |
Ile 365 | - | expression tag |
Ser 366 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Nh2 37 | - | amidation |
PDB | External Database | Details |
---|---|---|
Ala 188 | Gly 188 | conflict |
Arg 484 | Lys 484 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 167565.0 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 5140.6 | |
All* | Total formula weight | 172705.6 |