8H8J
Lodoxamide-bound GPR35 in complex with G13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein subunit alpha-13 | polymer | 362 | 42423.6 | 1 | UniProt (Q14344) Pfam (PF00503) | Homo sapiens (human) | G alpha-13,G-protein subunit alpha-13 |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | G-protein coupled receptor 35 | polymer | 308 | 33972.0 | 1 | UniProt (Q9HC97) Pfam (PF00001) | Homo sapiens (human) | Kynurenic acid receptor,KYNA receptor |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (H) | scFv16 | polymer | 247 | 26277.3 | 1 | Mus musculus | ||
| 6 | F (C) | 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) | non-polymer | 311.6 | 1 | Chemie (WYB) PubChem (44564) | |||
| 7 | G (C) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 8 | H, I, J (C) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) PubChem (5997) |
Sequence modifications
A: 34 - 378 (UniProt: Q14344)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Cys 3 | - | expression tag |
| Thr 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Ser 6 | - | expression tag |
| Ala 7 | - | expression tag |
| Glu 8 | - | expression tag |
| Asp 9 | - | expression tag |
| Lys 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Val 13 | - | expression tag |
| Glu 14 | - | expression tag |
| Arg 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Lys 17 | - | expression tag |
| Met 18 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 150761.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1511.7 | |
| All* | Total formula weight | 152272.8 |
