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8H8J

Lodoxamide-bound GPR35 in complex with G13

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001569biological_processbranching involved in blood vessel morphogenesis
A0001664molecular_functionG protein-coupled receptor binding
A0001701biological_processin utero embryonic development
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005834cellular_componentheterotrimeric G-protein complex
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007266biological_processRho protein signal transduction
A0008217biological_processregulation of blood pressure
A0008360biological_processregulation of cell shape
A0010762biological_processregulation of fibroblast migration
A0016020cellular_componentmembrane
A0019001molecular_functionguanyl nucleotide binding
A0030154biological_processcell differentiation
A0030168biological_processplatelet activation
A0031526cellular_componentbrush border membrane
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
A0031752molecular_functionD5 dopamine receptor binding
A0035556biological_processintracellular signal transduction
A0042470cellular_componentmelanosome
A0046872molecular_functionmetal ion binding
A0051056biological_processregulation of small GTPase mediated signal transduction
A0070062cellular_componentextracellular exosome
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
A1904753biological_processnegative regulation of vascular associated smooth muscle cell migration
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0004930molecular_functionG protein-coupled receptor activity
C0004950molecular_functionchemokine receptor activity
C0005886cellular_componentplasma membrane
C0007010biological_processcytoskeleton organization
C0007186biological_processG protein-coupled receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0016020cellular_componentmembrane
C0016494molecular_functionC-X-C chemokine receptor activity
C0035025biological_processpositive regulation of Rho protein signal transduction
C0070098biological_processchemokine-mediated signaling pathway
C1901386biological_processnegative regulation of voltage-gated calcium channel activity
C1904456biological_processnegative regulation of neuronal action potential
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. MSIsLVTAIAVDRYVaV
ChainResidueDetails
CMET102-VAL118

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299
BVAL327-GLY341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
GALA2
ASER62
ASER174
ALEU198
ATHR204
AASN292
AALA350

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
CASP113-ALA135
CTHR196-MET218
CALA280-ALA309

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68

site_idSWS_FT_FI4
Number of Residues47
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
CHIS78-GLN90
CGLN157-ALA174
CARG240-LEU258

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
CLEU91-VAL112

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
CVAL136-ILE156

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
CPHE175-VAL195

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
CVAL219-VAL239

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
CTYR259-MET279

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:35101446
ChainResidueDetails
CSER287
CSER294

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine; by GRK5 and GRK6 => ECO:0000269|PubMed:35101446
ChainResidueDetails
CSER300
CSER303

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:35101446
ChainResidueDetails
CTHR307

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN2

222036

PDB entries from 2024-07-03

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