8H1T
Cryo-EM structure of BAP1-ASXL1 bound to chromatosome
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Histone H3.1 | polymer | 136 | 15437.2 | 2 | UniProt (P68431) Pfam (PF00125) In PDB | Homo sapiens (human) | |
2 | B, F | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (P62805) Pfam (PF15511) In PDB | Homo sapiens (human) | |
3 | C, G | Histone H2A type 1-D | polymer | 130 | 14137.5 | 2 | UniProt (P20671) Pfam (PF00125) Pfam (PF16211) In PDB | Homo sapiens (human) | Histone H2A.3,Histone H2A/g |
4 | D, H | Histone H2B type 2-E | polymer | 126 | 13951.2 | 2 | UniProt (Q16778) Pfam (PF00125) In PDB | Homo sapiens (human) | Histone H2B-GL105,Histone H2B.q,H2B/q |
5 | I | DNA (187-MER) | polymer | 187 | 57438.5 | 1 | Homo sapiens (human) | ||
6 | J | DNA (187-MER) | polymer | 187 | 58031.0 | 1 | Homo sapiens (human) | ||
7 | K | Histone H1.4 | polymer | 229 | 23190.9 | 1 | UniProt (P10412) Pfam (PF00538) In PDB | Homo sapiens (human) | Histone H1b,Histone H1s-4 |
8 | L | Ubiquitin carboxyl-terminal hydrolase BAP1 | polymer | 729 | 80456.6 | 1 | UniProt (Q92560) Pfam (PF01088) Pfam (PF18031) In PDB | Homo sapiens (human) | BRCA1-associated protein 1,Cerebral protein 6 |
9 | M | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) Pfam (PF00240) In PDB | Homo sapiens (human) | |
10 | N | Polycomb group protein ASXL1 | polymer | 378 | 41788.6 | 1 | UniProt (Q8IXJ9) Pfam (PF05066) Pfam (PF13919) In PDB | Homo sapiens (human) | Additional sex combs-like protein 1 |
Sequence modifications
K: 0 - 218 (UniProt: P10412)
L: 1 - 729 (UniProt: Q92560)
PDB | External Database | Details |
---|---|---|
Met -2 | - | initiating methionine |
Gly -1 | - | expression tag |
Leu 219 | - | expression tag |
Glu 220 | - | expression tag |
His 221 | - | expression tag |
His 222 | - | expression tag |
His 223 | - | expression tag |
His 224 | - | expression tag |
His 225 | - | expression tag |
His 226 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Ser 91 | Cys 91 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 14 |
Total formula weight | 379323.1 | |
All* | Total formula weight | 379323.1 |