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8GVX

Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, F, G, H
(B, A, C, D)
Short transient receptor potential channel 5polymer77389951.94UniProt (Q9UL62)
Pfam (PF12796)
Pfam (PF00023)
Pfam (PF08344)
Pfam (PF00520)
Homo sapiens (human)TrpC5,Transient receptor protein 5,TRP-5,hTRP-5,hTRP5
2B, C, D, E
(F, E, G, H)
Guanine nucleotide-binding protein G(i) subunit alpha-3polymer36041399.04UniProt (P08754)
Pfam (PF00503)
Homo sapiens (human)G(i) alpha-3
3BA, I, R, W
(D, B, A, C)
PHOSPHATIDYLETHANOLAMINEnon-polymer734.04Chemie (PTY)
4CA, J, S, X
(D, B, A, C)
CHOLESTEROL HEMISUCCINATEnon-polymer486.74Chemie (Y01)
5DA, K, T, Y
(D, B, A, C)
ZINC IONnon-polymer65.44Chemie (ZN)
6EA, L, U, Z
(D, B, A, C)
CALCIUM IONnon-polymer40.14Chemie (CA)
7AA, FA, M, V
(C, D, B, A)
(2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoatenon-polymer594.94Chemie (YZY)
8N, O, P, Q
(F, E, G, H)
GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.24Chemie (GTP)
Sequence modifications
B, A, C, D: 1 - 765 (UniProt: Q9UL62)
PDBExternal DatabaseDetails
Ser 766-expression tag
Arg 767-expression tag
Leu 768-expression tag
Glu 769-expression tag
Val 770-expression tag
Leu 771-expression tag
Phe 772-expression tag
Gln 773-expression tag
F, E, G, H: 1 - 354 (UniProt: P08754)
PDBExternal DatabaseDetails
His 119-insertion
His 119-insertion
His 119-insertion
His 119-insertion
His 119-insertion
His 119-insertion
Leu 204Gln 204engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight525403.8
Non-Polymers*Number of molecules24
Total formula weight9777.5
All*Total formula weight535181.3
*Water molecules are not included.

227561

PDB entries from 2024-11-20

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