8GVX
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005262 | molecular_function | calcium channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0055085 | biological_process | transmembrane transport |
A | 0070588 | biological_process | calcium ion transmembrane transport |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005262 | molecular_function | calcium channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0055085 | biological_process | transmembrane transport |
B | 0070588 | biological_process | calcium ion transmembrane transport |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005262 | molecular_function | calcium channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0055085 | biological_process | transmembrane transport |
C | 0070588 | biological_process | calcium ion transmembrane transport |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005262 | molecular_function | calcium channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0055085 | biological_process | transmembrane transport |
D | 0070588 | biological_process | calcium ion transmembrane transport |
E | 0003924 | molecular_function | GTPase activity |
E | 0005525 | molecular_function | GTP binding |
E | 0007165 | biological_process | signal transduction |
E | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
E | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
E | 0019001 | molecular_function | guanyl nucleotide binding |
E | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
F | 0003924 | molecular_function | GTPase activity |
F | 0005525 | molecular_function | GTP binding |
F | 0007165 | biological_process | signal transduction |
F | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
F | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
F | 0019001 | molecular_function | guanyl nucleotide binding |
F | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
G | 0003924 | molecular_function | GTPase activity |
G | 0005525 | molecular_function | GTP binding |
G | 0007165 | biological_process | signal transduction |
G | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
G | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
G | 0019001 | molecular_function | guanyl nucleotide binding |
G | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
H | 0003924 | molecular_function | GTPase activity |
H | 0005525 | molecular_function | GTP binding |
H | 0007165 | biological_process | signal transduction |
H | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
H | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
H | 0019001 | molecular_function | guanyl nucleotide binding |
H | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
Functional Information from PROSITE/UniProt
site_id | PS00962 |
Number of Residues | 12 |
Details | RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG |
Chain | Residue | Details |
B | LEU493-GLY504 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S |
Chain | Residue | Details |
F | GLU43 | |
E | GLU43 | |
G | GLU43 | |
H | GLU43 | |
F | LEU175 | |
F | ASN269 | |
E | LEU175 | |
E | ASN269 | |
G | LEU175 | |
G | ASN269 | |
H | LEU175 | |
H | ASN269 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19478087, ECO:0007744|PDB:2V4Z |
Chain | Residue | Details |
F | SER47 | |
E | SER47 | |
G | SER47 | |
H | SER47 | |
A | MET438-VAL458 | |
A | MET471-LEU491 | |
A | MET513-ASN533 | |
A | MET604-MET624 | |
C | LEU331-SER351 | |
C | PRO399-ILE419 | |
C | MET438-VAL458 | |
C | MET471-LEU491 | |
C | MET513-ASN533 | |
C | MET604-MET624 | |
D | LEU331-SER351 | |
D | PRO399-ILE419 | |
D | MET438-VAL458 | |
D | MET471-LEU491 | |
D | MET513-ASN533 | |
D | MET604-MET624 | |
F | THR181 | |
E | THR181 | |
G | THR181 | |
H | THR181 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R, ECO:0007744|PDB:4G5S |
Chain | Residue | Details |
A | LYS459-GLU470 | |
A | GLY534-THR603 | |
C | PRO352-PRO398 | |
C | LYS459-GLU470 | |
C | GLY534-THR603 | |
D | PRO352-PRO398 | |
D | LYS459-GLU470 | |
D | GLY534-THR603 | |
F | ASP150 | |
E | ASP150 | |
G | ASP150 | |
H | ASP150 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19478087, ECO:0007744|PDB:2V4Z |
Chain | Residue | Details |
E | ASP200 | |
F | ASP200 | |
G | ASP200 | |
H | ASP200 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0007744|PDB:2IHB, ECO:0007744|PDB:2ODE, ECO:0007744|PDB:2V4Z, ECO:0007744|PDB:4G5O, ECO:0007744|PDB:4G5R |
Chain | Residue | Details |
F | ALA326 | |
E | ALA326 | |
G | ALA326 | |
H | ALA326 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250 |
Chain | Residue | Details |
F | ARG178 | |
E | ARG178 | |
G | ARG178 | |
H | ARG178 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | MOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 |
Chain | Residue | Details |
F | LEU204 | |
E | LEU204 | |
G | LEU204 | |
H | LEU204 |
site_id | SWS_FT_FI8 |
Number of Residues | 4 |
Details | MOD_RES: ADP-ribosylcysteine; by pertussis toxin => ECO:0000250 |
Chain | Residue | Details |
F | CYS351 | |
E | CYS351 | |
G | CYS351 | |
H | CYS351 |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805 |
Chain | Residue | Details |
F | GLY2 | |
E | GLY2 | |
G | GLY2 | |
H | GLY2 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
Chain | Residue | Details |
F | CYS3 | |
E | CYS3 | |
G | CYS3 | |
H | CYS3 |