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8GT4

Crystal structure of human cardiac alpha actin Q137A mutant (AMPPNP state) in complex with fragmin F1 domain

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AActin, alpha cardiac muscle 1polymer39143587.51UniProt (P68032)
Pfam (PF00022)
In PDB
Homo sapiens (human)Alpha-cardiac actin
2BActin-binding protein fragmin Ppolymer16018099.31UniProt (Q94707)
Pfam (PF00626)
In PDB
Physarum polycephalum
3APHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21Chemie (ANP)
4AMAGNESIUM IONnon-polymer24.31Chemie (MG)
5A, B1,2-ETHANEDIOLnon-polymer62.12Chemie (EDO)
6APHOSPHATE IONnon-polymer95.02Chemie (PO4)
7BCALCIUM IONnon-polymer40.12Chemie (CA)
8waterwater18.0697Chemie (HOH)
Sequence modifications
A: 1 - 375 (UniProt: P68032)
PDBExternal DatabaseDetails
Met -15-initiating methionine
Gly -14-expression tag
Trp -13-expression tag
Ser -12-expression tag
His -11-expression tag
Pro -10-expression tag
Gln -9-expression tag
Phe -8-expression tag
Glu -7-expression tag
Lys -6-expression tag
Gly -5-expression tag
Gly -4-expression tag
Ile -3-expression tag
Glu -2-expression tag
Gly -1-expression tag
Arg 0-expression tag
Ala 137Gln 139engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight61686.8
Non-Polymers*Number of molecules8
Total formula weight924.7
All*Total formula weight62611.5
*Water molecules are not included.

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PDB entries from 2024-06-12

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