8GT4
Crystal structure of human cardiac alpha actin Q137A mutant (AMPPNP state) in complex with fragmin F1 domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Actin, alpha cardiac muscle 1 | polymer | 391 | 43587.5 | 1 | UniProt (P68032) Pfam (PF00022) In PDB | Homo sapiens (human) | Alpha-cardiac actin |
2 | B | Actin-binding protein fragmin P | polymer | 160 | 18099.3 | 1 | UniProt (Q94707) Pfam (PF00626) In PDB | Physarum polycephalum | |
3 | A | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
6 | A | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
7 | B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
8 | water | water | 18.0 | 697 | Chemie (HOH) |
Sequence modifications
A: 1 - 375 (UniProt: P68032)
PDB | External Database | Details |
---|---|---|
Met -15 | - | initiating methionine |
Gly -14 | - | expression tag |
Trp -13 | - | expression tag |
Ser -12 | - | expression tag |
His -11 | - | expression tag |
Pro -10 | - | expression tag |
Gln -9 | - | expression tag |
Phe -8 | - | expression tag |
Glu -7 | - | expression tag |
Lys -6 | - | expression tag |
Gly -5 | - | expression tag |
Gly -4 | - | expression tag |
Ile -3 | - | expression tag |
Glu -2 | - | expression tag |
Gly -1 | - | expression tag |
Arg 0 | - | expression tag |
Ala 137 | Gln 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 61686.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 924.7 | |
All* | Total formula weight | 62611.5 |