8GRM
Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3 | polymer | 98 | 11562.6 | 2 | UniProt (A0A6I9KHI6) Pfam (PF00125) UniProt (by SIFTS) (P68431) | Homo sapiens (human) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 85 | 9704.4 | 2 | UniProt (A0A3Q2SS86) Pfam (PF15511) UniProt (by SIFTS) (P62805) | Homo sapiens (human) | |
| 3 | C, G (C, G) | Histone H2A type 1-B/E | polymer | 109 | 11995.1 | 2 | UniProt (P04908) Pfam (PF00125) Pfam (PF16211) | Homo sapiens | Histone H2A.2,Histone H2A/a,Histone H2A/m |
| 4 | D (D) | Histone H2B type 1-K | polymer | 96 | 10736.4 | 1 | UniProt (O60814) Pfam (PF00125) | Homo sapiens | H2B K,HIRA-interacting protein 1 |
| 5 | H (H) | Histone H2B type 1-K | polymer | 95 | 10607.2 | 1 | UniProt (O60814) Pfam (PF00125) | Homo sapiens (human) | H2B K,HIRA-interacting protein 1 |
| 6 | I (M) | COMMD3 protein | polymer | 101 | 11865.1 | 1 | UniProt (Q6IB93) Pfam (PF13923) UniProt (by SIFTS) (P35226) | Homo sapiens (human) | |
| 7 | J (N) | Ring1B | polymer | 101 | 11530.5 | 1 | UniProt (Q99496) Pfam (PF13923) | Homo sapiens | |
| 8 | K (I) | DNA (144-MER) | polymer | 144 | 44217.2 | 1 | Homo sapiens | ||
| 9 | L (J) | DNA (145-MER) | polymer | 145 | 44992.6 | 1 | Homo sapiens | ||
| 10 | M (O) | Ubiquitin | polymer | 76 | 8576.8 | 1 | UniProt (P0CG47) Pfam (PF00240) | Homo sapiens (human) | |
| 11 | N (P) | UbcH5b | polymer | 146 | 16575.8 | 1 | Pfam (PF00179) UniProt (by SIFTS) (P62837) | Homo sapiens | |
| 12 | O, P, Q, R (M, N) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
N: 16 - 116 (UniProt: Q99496)
| PDB | External Database | Details |
|---|---|---|
| Leu 76 | Ile 76 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 225625.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 225887.3 |
