8GK3

Cytochrome P450 3A7 in complex with Dehydroepiandrosterone sulfate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Cytochrome P450 3A7	polymer	486	55380.3	12	UniProt (P24462) Pfam (PF00067) In PDB	Homo sapiens (human)	CYPIIIA7,Cytochrome P450-HFLA,P450HLp2
2	E, F, G, H, A...	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	12	Chemie (HEM)
3	D, E, H, A, I...	17-oxoandrost-5-en-3beta-yl hydrogen sulfate	non-polymer		368.5	24	Chemie (ZWY)
4		water	water		18.0	32	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 24 - 503 (UniProt: P24462)

PDB	External Database	Details
Met 22	-	initiating methionine
Ala 23	-	expression tag
Gly 69	Arg 69	conflict
Gly 77	Cys 77	conflict
Glu 244	Lys 244	conflict
Ala 421	Lys 421	conflict
Ala 422	Lys 422	conflict
Ala 424	Lys 424	conflict
His 504	-	expression tag
His 505	-	expression tag
His 506	-	expression tag
His 507	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	664563.9
Non-Polymers*	Number of molecules	36
	Total formula weight	16241.6
All*	Total formula weight	680805.4

*Water molecules are not included.