8GK3
Cytochrome P450 3A7 in complex with Dehydroepiandrosterone sulfate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Cytochrome P450 3A7 | polymer | 486 | 55380.3 | 12 | UniProt (P24462) Pfam (PF00067) | Homo sapiens (human) | CYPIIIA7,Cytochrome P450-HFLA,P450HLp2 |
| 2 | DA, IA, JA, KA, M... (E, F, G, H, A...) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 12 | Chemie (HEM) | |||
| 3 | AA, BA, CA, EA, FA... (D, E, H, A, I...) | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate | non-polymer | 368.5 | 24 | Chemie (ZWY) PubChem (24867494) PubChem (50989979) PubChem (5244) PubChem (135337) PubChem (9799421) PubChem (10317945) PubChem (71752218) PubChem (73759687) PubChem (87399275) PubChem (122130634) PubChem (12594) PubChem (83891) PubChem (124318506) PubChem (124784292) PubChem (124784293) PubChem (124910878) PubChem (6604099) PubChem (126969889) PubChem (13474726) PubChem (133126796) PubChem (162910008) PubChem (165431259) | |||
| 4 | AB, BB, CB, DB, EB... (G, H, I, J, K...) | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 24 - 503 (UniProt: P24462)
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | initiating methionine |
| Ala 23 | - | expression tag |
| Gly 69 | Arg 69 | conflict |
| Gly 77 | Cys 77 | conflict |
| Glu 244 | Lys 244 | conflict |
| Ala 421 | Lys 421 | conflict |
| Ala 422 | Lys 422 | conflict |
| Ala 424 | Lys 424 | conflict |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 664563.9 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 16241.6 | |
| All* | Total formula weight | 680805.4 |
