8GJE
HIV-1 Env subtype C CZA97.12 SOSIP.664 in complex with 3BNC117 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (A, C, D) | CZA97.12 SOSIP.664 Envelope glycoprotein gp120 | polymer | 503 | 56995.1 | 3 | UniProt (Q994M9) | Human immunodeficiency virus 1 | |
| 2 | B, F, J (B, E, F) | CZA97.12 SOSIP.664 Envelope glycoprotein gp41 | polymer | 153 | 17279.7 | 3 | UniProt (Q994M9) | Human immunodeficiency virus 1 | |
| 3 | C, G, K (H, G, I) | 3BNC117 Fab heavy chain | polymer | 226 | 24656.5 | 3 | Homo sapiens | ||
| 4 | D, H, L (L, J, K) | 3BNC117 kappa light chain | polymer | 206 | 23022.7 | 3 | Homo sapiens | ||
| 5 | BA, CA, EA, FA, HA... (b, c, e, f, h...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 18 | In PDB GlyTouCan (G42666HT) | |||
| 6 | GA, O, X (g, O, X) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 3 | In PDB GlyTouCan (G32152BH) | |||
| 7 | AA, JA, R (a, j, R) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 3 | In PDB GlyTouCan (G68668TB) | |||
| 8 | DA, MA, U (d, m, U) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 3 | In PDB GlyTouCan (G55220VL) | |||
| 9 | AB, BB, CB, DB, EB... (C, E, J, D, A...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 33 | Chemie (NAG) |
Sequence modifications
A, C, D: 31 - 511 (UniProt: Q994M9)
B, E, F: 512 - 664 (UniProt: Q994M9)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Asp -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Met -1 | - | expression tag |
| Lys 0 | - | expression tag |
| Arg 1 | - | expression tag |
| Gly 2 | - | expression tag |
| Leu 3 | - | expression tag |
| Cys 4 | - | expression tag |
| Cys 5 | - | expression tag |
| Val 6 | - | expression tag |
| Leu 7 | - | expression tag |
| Leu 8 | - | expression tag |
| Leu 9 | - | expression tag |
| Cys 10 | - | expression tag |
| Gly 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Val 13 | - | expression tag |
| Phe 14 | - | expression tag |
| Val 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Pro 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Gln 19 | - | expression tag |
| Glu 20 | - | expression tag |
| Ile 21 | - | expression tag |
| His 22 | - | expression tag |
| Ala 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Phe 25 | - | expression tag |
| Arg 26 | - | expression tag |
| Arg 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Arg 30 | - | expression tag |
| Cys 501 | Ala 485 | engineered mutation |
| Arg 509 | Glu 493 | engineered mutation |
| Arg 510 | Lys 494 | engineered mutation |
| Arg 512 | - | insertion |
| Arg 513 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Met 535 | Leu 519 | engineered mutation |
| Pro 559 | Ile 543 | engineered mutation |
| Lys 567 | Gln 551 | engineered mutation |
| Cys 605 | Thr 589 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 365861.8 | |
| Branched | Number of molecules | 27 |
| Total formula weight | 18220.7 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 7299.9 | |
| All* | Total formula weight | 391382.4 |
