8GHE
The structure of h12-LOX in tetrameric form bound to endogenous inhibitor oleoyl-CoA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (B, C, D, A) | Polyunsaturated fatty acid lipoxygenase ALOX12 | polymer | 669 | 76582.7 | 4 | UniProt (P18054) Pfam (PF01477) Pfam (PF00305) | Homo sapiens (human) | Arachidonate (12S)-lipoxygenase,12S-LOX,12S-lipoxygenase,Arachidonate (15S)-lipoxygenase,Linoleate (13S)-lipoxygenase,Lipoxin synthase 12-LO,Platelet-type lipoxygenase 12 |
| 2 | E, F, G, H (B, C, D, A) | FE (II) ION | non-polymer | 55.8 | 4 | Chemie (FE2) | |||
| 3 | I (A) | S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name) | non-polymer | 1032.0 | 1 | Chemie (3VV) | |||
| 4 | J, K, L, M (B, C, D, A) | water | water | 18.0 | 830 | Chemie (HOH) |
Sequence modifications
B, C, D, A: 2 - 663 (UniProt: P18054)
| PDB | External Database | Details |
|---|---|---|
| Met -5 | - | initiating methionine |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| Ser 322 | Asn 322 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 306330.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1255.4 | |
| All* | Total formula weight | 307586.2 |
