8GHC

The structure of h12-LOX in dimeric form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Polyunsaturated fatty acid lipoxygenase ALOX12	polymer	669	76582.7	2	UniProt (P18054) Pfam (PF01477) Pfam (PF00305)	Homo sapiens (human)	Arachidonate (12S)-lipoxygenase,12S-LOX,12S-lipoxygenase,Arachidonate (15S)-lipoxygenase,Linoleate (13S)-lipoxygenase,Lipoxin synthase 12-LO,Platelet-type lipoxygenase 12
2	C, D (A, B)	FE (II) ION	non-polymer		55.8	2	Chemie (FE2)

Sequence modifications

A, B: 2 - 663 (UniProt: P18054)

PDB	External Database	Details
Met -5	-	initiating methionine
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Ser 322	Asn 322	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	153165.4
Non-Polymers*	Number of molecules	2
	Total formula weight	111.7
All*	Total formula weight	153277.1

*Water molecules are not included.