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8GHC

The structure of h12-LOX in dimeric form

Functional Information from GO Data
ChainGOidnamespacecontents
A0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0010656biological_processnegative regulation of muscle cell apoptotic process
A0016020cellular_componentmembrane
A0016165molecular_functionlinoleate 13S-lipoxygenase activity
A0016491molecular_functionoxidoreductase activity
A0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A0016787molecular_functionhydrolase activity
A0019369biological_processarachidonate metabolic process
A0019372biological_processlipoxygenase pathway
A0019395biological_processfatty acid oxidation
A0033559biological_processunsaturated fatty acid metabolic process
A0034440biological_processlipid oxidation
A0042383cellular_componentsarcolemma
A0042554biological_processsuperoxide anion generation
A0042759biological_processlong-chain fatty acid biosynthetic process
A0043651biological_processlinoleic acid metabolic process
A0046872molecular_functionmetal ion binding
A0047977molecular_functionhepoxilin-epoxide hydrolase activity
A0050473molecular_functionarachidonate 15-lipoxygenase activity
A0051122biological_processhepoxilin biosynthetic process
A0051213molecular_functiondioxygenase activity
A0061436biological_processestablishment of skin barrier
A0070062cellular_componentextracellular exosome
A0090331biological_processnegative regulation of platelet aggregation
A1901751biological_processleukotriene A4 metabolic process
A2001303biological_processlipoxin A4 biosynthetic process
A2001306biological_processlipoxin B4 biosynthetic process
B0004052molecular_functionarachidonate 12(S)-lipoxygenase activity
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0010656biological_processnegative regulation of muscle cell apoptotic process
B0016020cellular_componentmembrane
B0016165molecular_functionlinoleate 13S-lipoxygenase activity
B0016491molecular_functionoxidoreductase activity
B0016702molecular_functionoxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
B0016787molecular_functionhydrolase activity
B0019369biological_processarachidonate metabolic process
B0019372biological_processlipoxygenase pathway
B0019395biological_processfatty acid oxidation
B0033559biological_processunsaturated fatty acid metabolic process
B0034440biological_processlipid oxidation
B0042383cellular_componentsarcolemma
B0042554biological_processsuperoxide anion generation
B0042759biological_processlong-chain fatty acid biosynthetic process
B0043651biological_processlinoleic acid metabolic process
B0046872molecular_functionmetal ion binding
B0047977molecular_functionhepoxilin-epoxide hydrolase activity
B0050473molecular_functionarachidonate 15-lipoxygenase activity
B0051122biological_processhepoxilin biosynthetic process
B0051213molecular_functiondioxygenase activity
B0061436biological_processestablishment of skin barrier
B0070062cellular_componentextracellular exosome
B0090331biological_processnegative regulation of platelet aggregation
B1901751biological_processleukotriene A4 metabolic process
B2001303biological_processlipoxin A4 biosynthetic process
B2001306biological_processlipoxin B4 biosynthetic process
Functional Information from PROSITE/UniProt
site_idPS00081
Number of Residues11
DetailsLIPOXYGENASE_2 Lipoxygenases iron-binding region signature 2. LHPIfKFLiPH
ChainResidueDetails
ALEU382-HIS392

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. FTCTAQH
ChainResidueDetails
APHE534-HIS540

site_idPS00711
Number of Residues15
DetailsLIPOXYGENASE_1 Lipoxygenases iron-binding region signature 1. HEiqyHlLNTHLVaE
ChainResidueDetails
AHIS355-GLU369

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING:
ChainResidueDetails
AHIS360
AHIS365
AHIS540
BHIS360
BHIS365
BHIS540

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00726
ChainResidueDetails
AASN544
AILE663
BASN544
BILE663

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:F1LQ70
ChainResidueDetails
ASER246
BSER246

237992

PDB entries from 2025-06-25

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