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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8GFA

Cryo-EM structure of human TRPV1 in complex with the analgesic drug SB-366791

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, DTransient receptor potential cation channel subfamily V member 1polymer1102124575.34UniProt (Q8NER1)
Pfam (PF12796)
Pfam (PF00023)
Pfam (PF00520)
In PDB		Homo sapiens (human)TrpV1,Capsaicin receptor,Osm-9-like TRP channel 1,OTRPC1,Vanilloid receptor 1
2B, C, A, D(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphatenon-polymer760.136Chemie (POV)
3C, A, D, B(2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamidenon-polymer287.74Chemie (ZEI)
4B, C, A, D2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diolnon-polymer516.84Chemie (DU0)
5C, ASODIUM IONnon-polymer23.02Chemie (NA)
6waterwater18.0105Chemie (HOH)
Sequence modifications
A, B, C, D: 2 - 839 (UniProt: Q8NER1)
PDBExternal DatabaseDetails
Met -1-initiating methionine
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Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight498301.1
Non-Polymers*Number of molecules46
Total formula weight30626.7
All*Total formula weight528927.8
*Water molecules are not included.

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PDB entries from 2024-07-10

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