8GCR
HPV16 E6-E6AP-p53 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Maltose/maltodextrin-binding periplasmic protein,Protein E6 | polymer | 541 | 61190.6 | 1 | UniProt (P0AEY0) UniProt (P03126) Pfam (PF01547) Pfam (PF00518) UniProt (by SIFTS) (P0AEX9) | Escherichia coli O157:H7 | MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP |
| 2 | B (B) | Cellular tumor antigen p53 | polymer | 220 | 24643.9 | 1 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 3 | C (R) | Ubiquitin-protein ligase E3A | polymer | 903 | 104305.3 | 1 | UniProt (Q05086) Pfam (PF16558) Pfam (PF00632) | Homo sapiens (human) | E6AP ubiquitin-protein ligase,HECT-type ubiquitin transferase E3A,Human papillomavirus E6-associated protein,Oncogenic protein-associated protein E6-AP,Renal carcinoma antigen NY-REN-54 |
| 4 | D, E, F (A, B) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
A: -381 - -12 (UniProt: P0AEY0)
A: 1 - 158 (UniProt: P03126)
B: 94 - 312 (UniProt: P04637)
R: 1 - 875 (UniProt: Q05086)
| PDB | External Database | Details |
|---|---|---|
| Met -382 | - | initiating methionine |
| Gly -11 | - | linker |
| Gly -10 | - | linker |
| Gly -9 | - | linker |
| Gly -8 | - | linker |
| Ser -7 | - | linker |
| Glu -6 | - | linker |
| Asn -5 | - | linker |
| Leu -4 | - | linker |
| Tyr -3 | - | linker |
| Phe -2 | - | linker |
| Gln -1 | - | linker |
| Gly 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 87 | Cys 87 | engineered mutation |
| Ser 104 | Cys 104 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
| Ser 147 | Cys 147 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 93 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 876 | - | expression tag |
| Asn 877 | - | expression tag |
| Leu 878 | - | expression tag |
| Tyr 879 | - | expression tag |
| Phe 880 | - | expression tag |
| Gln 881 | - | expression tag |
| Gly 882 | - | expression tag |
| His 883 | - | expression tag |
| His 884 | - | expression tag |
| His 885 | - | expression tag |
| His 886 | - | expression tag |
| His 887 | - | expression tag |
| His 888 | - | expression tag |
| Gly 889 | - | expression tag |
| Leu 890 | - | expression tag |
| Asn 891 | - | expression tag |
| Asp 892 | - | expression tag |
| Ile 893 | - | expression tag |
| Phe 894 | - | expression tag |
| Glu 895 | - | expression tag |
| Ala 896 | - | expression tag |
| Gln 897 | - | expression tag |
| Lys 898 | - | expression tag |
| Ile 899 | - | expression tag |
| Glu 900 | - | expression tag |
| Trp 901 | - | expression tag |
| His 902 | - | expression tag |
| Glu 903 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 190139.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 190336.0 |
