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8GCR

HPV16 E6-E6AP-p53 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0008270molecular_functionzinc ion binding
A0008643biological_processcarbohydrate transport
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0030162biological_processregulation of proteolysis
A0030165molecular_functionPDZ domain binding
A0030288cellular_componentouter membrane-bounded periplasmic space
A0030430cellular_componenthost cell cytoplasm
A0032489biological_processregulation of Cdc42 protein signal transduction
A0033668biological_processsymbiont-mediated suppression of host apoptosis
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
A0039548biological_processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
A0039648biological_processsymbiont-mediated perturbation of host ubiquitin-like protein modification
A0039653biological_processsymbiont-mediated suppression of host transcription
A0042025cellular_componenthost cell nucleus
A0042597cellular_componentperiplasmic space
A0042802molecular_functionidentical protein binding
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0052031biological_processsymbiont-mediated perturbation of host defense response
A0052150biological_processsymbiont-mediated perturbation of host apoptosis
A0052170biological_processsymbiont-mediated suppression of host innate immune response
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060255biological_processregulation of macromolecule metabolic process
A0060326biological_processcell chemotaxis
A0080090biological_processregulation of primary metabolic process
A0140537molecular_functiontranscription regulator activator activity
A1901982molecular_functionmaltose binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
B0006915biological_processapoptotic process
R0000209biological_processprotein polyubiquitination
R0000502cellular_componentproteasome complex
R0003713molecular_functiontranscription coactivator activity
R0004842molecular_functionubiquitin-protein transferase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0006508biological_processproteolysis
R0006511biological_processubiquitin-dependent protein catabolic process
R0007420biological_processbrain development
R0008021cellular_componentsynaptic vesicle
R0008270molecular_functionzinc ion binding
R0010604biological_processpositive regulation of macromolecule metabolic process
R0016567biological_processprotein ubiquitination
R0016740molecular_functiontransferase activity
R0030518biological_processnuclear receptor-mediated steroid hormone signaling pathway
R0031398biological_processpositive regulation of protein ubiquitination
R0032570biological_processresponse to progesterone
R0042752biological_processregulation of circadian rhythm
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0045893biological_processpositive regulation of DNA-templated transcription
R0046872molecular_functionmetal ion binding
R0048167biological_processregulation of synaptic plasticity
R0048511biological_processrhythmic process
R0048513biological_processanimal organ development
R0048731biological_processsystem development
R0050804biological_processmodulation of chemical synaptic transmission
R0050847biological_processprogesterone receptor signaling pathway
R0051865biological_processprotein autoubiquitination
R0061630molecular_functionubiquitin protein ligase activity
R0070936biological_processprotein K48-linked ubiquitination
R0080090biological_processregulation of primary metabolic process
R0098978cellular_componentglutamatergic synapse
R0099524cellular_componentpostsynaptic cytosol
R1904262biological_processnegative regulation of TORC1 signaling
R1905528biological_processpositive regulation of Golgi lumen acidification
R2000058biological_processregulation of ubiquitin-dependent protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO-275-ASN-258

site_idPS00348
Number of Residues13
DetailsP53 p53 family signature. MCNSSCMGGMNRR
ChainResidueDetails
BMET237-ARG249

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsZinc finger: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04006","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues7
DetailsRegion: {"description":"Interaction with the 53BP2 SH3 domain"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues7
DetailsRegion: {"description":"Interaction with DNA"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"14534297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17015838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19515728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20142040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsSite: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38653238","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues17
DetailsRegion: {"description":"E6-binding"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"23581475","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 438
ChainResidueDetails

246905

PDB entries from 2025-12-31

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