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8GCR

HPV16 E6-E6AP-p53 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0005515molecular_functionprotein binding
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0006974biological_processDNA damage response
A0008643biological_processcarbohydrate transport
A0015144molecular_functioncarbohydrate transmembrane transporter activity
A0015768biological_processmaltose transport
A0016020cellular_componentmembrane
A0019049biological_processvirus-mediated perturbation of host defense response
A0030162biological_processregulation of proteolysis
A0030165molecular_functionPDZ domain binding
A0030288cellular_componentouter membrane-bounded periplasmic space
A0030430cellular_componenthost cell cytoplasm
A0034219biological_processcarbohydrate transmembrane transport
A0034289biological_processdetection of maltose stimulus
A0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
A0039548biological_processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
A0039648biological_processsymbiont-mediated perturbation of host ubiquitin-like protein modification
A0039653biological_processsymbiont-mediated suppression of host transcription
A0042025cellular_componenthost cell nucleus
A0042597cellular_componentperiplasmic space
A0042802molecular_functionidentical protein binding
A0042956biological_processmaltodextrin transmembrane transport
A0043190cellular_componentATP-binding cassette (ABC) transporter complex
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046872molecular_functionmetal ion binding
A0052150biological_processsymbiont-mediated perturbation of host apoptosis
A0055052cellular_componentATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A0055085biological_processtransmembrane transport
A0060326biological_processcell chemotaxis
A0090630biological_processactivation of GTPase activity
A1901982molecular_functionmaltose binding
A1990060cellular_componentmaltose transport complex
B0000976molecular_functiontranscription cis-regulatory region binding
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
B0006915biological_processapoptotic process
R0000209biological_processprotein polyubiquitination
R0000502cellular_componentproteasome complex
R0001541biological_processovarian follicle development
R0003713molecular_functiontranscription coactivator activity
R0004842molecular_functionubiquitin-protein transferase activity
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0006508biological_processproteolysis
R0006511biological_processubiquitin-dependent protein catabolic process
R0007420biological_processbrain development
R0016567biological_processprotein ubiquitination
R0016740molecular_functiontransferase activity
R0030521biological_processandrogen receptor signaling pathway
R0031398biological_processpositive regulation of protein ubiquitination
R0032570biological_processresponse to progesterone
R0035037biological_processsperm entry
R0035641biological_processlocomotory exploration behavior
R0042220biological_processresponse to cocaine
R0042542biological_processresponse to hydrogen peroxide
R0042752biological_processregulation of circadian rhythm
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0046872molecular_functionmetal ion binding
R0048167biological_processregulation of synaptic plasticity
R0048511biological_processrhythmic process
R0050804biological_processmodulation of chemical synaptic transmission
R0050847biological_processprogesterone receptor signaling pathway
R0051865biological_processprotein autoubiquitination
R0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R0060736biological_processprostate gland growth
R0061002biological_processnegative regulation of dendritic spine morphogenesis
R0061630molecular_functionubiquitin protein ligase activity
R0061743biological_processmotor learning
R0070936biological_processprotein K48-linked ubiquitination
R0098978cellular_componentglutamatergic synapse
R1904262biological_processnegative regulation of TORC1 signaling
R1905528biological_processpositive regulation of Golgi lumen acidification
R1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
R2000058biological_processregulation of ubiquitin-dependent protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS00348
Number of Residues13
DetailsP53 p53 family signature. MCNSSCMGGMNRR
ChainResidueDetails
BMET237-ARG249

site_idPS01037
Number of Residues18
DetailsSBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN
ChainResidueDetails
APRO-275-ASN-258

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues39
DetailsZN_FING: C4-type; atypical => ECO:0000269|PubMed:21947926
ChainResidueDetails
RCYS44-CYS83
ACYS110-CYS146

site_idSWS_FT_FI2
Number of Residues1
DetailsACT_SITE: Glycyl thioester intermediate
ChainResidueDetails
RCYS843
BHIS179
BCYS238
BCYS242

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:19690332
ChainResidueDetails
RSER218

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:23581475
ChainResidueDetails
RTYR659

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462
ChainResidueDetails
BSER183
BSER269

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462
ChainResidueDetails
BTHR284

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314
ChainResidueDetails
BLYS305

site_idSWS_FT_FI8
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131
ChainResidueDetails
BLYS291
BLYS292

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 438
ChainResidueDetails
RARG529unknown
RGLU562unknown
RGLU573unknown
RASP630electrostatic stabiliser
RHIS841
RCYS843covalent catalysis

223166

PDB entries from 2024-07-31

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