8G66

Structure with SJ3149

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	DNA damage-binding protein 1	polymer	860	96033.9	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
2	B, E (B, E)	Protein cereblon	polymer	426	48976.1	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
3	C, F (C, F)	Casein kinase I isoform alpha	polymer	341	39302.2	2	UniProt (P48729) Pfam (PF00069)	Homo sapiens (human)	CKI-alpha,CK1
4	G, I (B, E)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	H (B)	(3S)-3-{5-[(1,2-benzoxazol-3-yl)amino]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}piperidine-2,6-dione	non-polymer		376.4	1	Chemie (YOT)

Sequence modifications

A, D: 1 - 699 (UniProt: Q16531)

PDB	External Database	Details
Met -23	-	initiating methionine
Gly -22	-	expression tag
Ser -21	-	expression tag
Ser -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Ser -13	-	expression tag
Ala -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Glu -9	-	expression tag
Asn -8	-	expression tag
Leu -7	-	expression tag
Tyr -6	-	expression tag
Phe -5	-	expression tag
Gln -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

A, D: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Gly 700	-	linker
Asn 701	-	linker
Gly 702	-	linker
Asn 703	-	linker
Ser 704	-	linker
Gly 705	-	linker

B, E: 41 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Met 17	-	initiating methionine
Asp 18	-	expression tag
Trp 19	-	expression tag
Ser 20	-	expression tag
His 21	-	expression tag
Pro 22	-	expression tag
Gln 23	-	expression tag
Phe 24	-	expression tag
Glu 25	-	expression tag
Lys 26	-	expression tag
Ser 27	-	expression tag
Ala 28	-	expression tag
Val 29	-	expression tag
Asp 30	-	expression tag
Glu 31	-	expression tag
Asn 32	-	expression tag
Leu 33	-	expression tag
Tyr 34	-	expression tag
Phe 35	-	expression tag
Gln 36	-	expression tag
Gly 37	-	expression tag
Gly 38	-	expression tag
Gly 39	-	expression tag
Arg 40	-	expression tag

C, F: 1 - 337 (UniProt: P48729)

PDB	External Database	Details
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	368624.6
Non-Polymers*	Number of molecules	3
	Total formula weight	507.2
All*	Total formula weight	369131.8

*Water molecules are not included.