8G66

Structure with SJ3149

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005634	cellular_component	nucleus
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0030177	biological_process	positive regulation of Wnt signaling pathway
B	0031333	biological_process	negative regulation of protein-containing complex assembly
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
B	0035641	biological_process	locomotory exploration behavior
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0060173	biological_process	limb development
C	0000045	biological_process	autophagosome assembly
C	0000166	molecular_function	nucleotide binding
C	0000775	cellular_component	chromosome, centromeric region
C	0000776	cellular_component	kinetochore
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
C	0005856	cellular_component	cytoskeleton
C	0005929	cellular_component	cilium
C	0006468	biological_process	protein phosphorylation
C	0007030	biological_process	Golgi organization
C	0007165	biological_process	signal transduction
C	0007166	biological_process	cell surface receptor signaling pathway
C	0010507	biological_process	negative regulation of autophagy
C	0010508	biological_process	positive regulation of autophagy
C	0016020	cellular_component	membrane
C	0016055	biological_process	Wnt signaling pathway
C	0016301	molecular_function	kinase activity
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0019082	biological_process	viral protein processing
C	0030111	biological_process	regulation of Wnt signaling pathway
C	0030877	cellular_component	beta-catenin destruction complex
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031669	biological_process	cellular response to nutrient levels
C	0031670	biological_process	cellular response to nutrient
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0035025	biological_process	positive regulation of Rho protein signal transduction
C	0036064	cellular_component	ciliary basal body
C	0038202	biological_process	TORC1 signaling
C	0042995	cellular_component	cell projection
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044546	biological_process	NLRP3 inflammasome complex assembly
C	0045095	cellular_component	keratin filament
C	0045104	biological_process	intermediate filament cytoskeleton organization
C	0051301	biological_process	cell division
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0106310	molecular_function	protein serine kinase activity
C	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
C	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
C	1904262	biological_process	negative regulation of TORC1 signaling
C	1904263	biological_process	positive regulation of TORC1 signaling
D	0003676	molecular_function	nucleic acid binding
D	0005634	cellular_component	nucleus
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0016020	cellular_component	membrane
E	0016567	biological_process	protein ubiquitination
E	0030177	biological_process	positive regulation of Wnt signaling pathway
E	0031333	biological_process	negative regulation of protein-containing complex assembly
E	0031334	biological_process	positive regulation of protein-containing complex assembly
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
E	0035641	biological_process	locomotory exploration behavior
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044325	molecular_function	transmembrane transporter binding
E	0046872	molecular_function	metal ion binding
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0060173	biological_process	limb development
F	0000045	biological_process	autophagosome assembly
F	0000166	molecular_function	nucleotide binding
F	0000775	cellular_component	chromosome, centromeric region
F	0000776	cellular_component	kinetochore
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005694	cellular_component	chromosome
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
F	0005856	cellular_component	cytoskeleton
F	0005929	cellular_component	cilium
F	0006468	biological_process	protein phosphorylation
F	0007030	biological_process	Golgi organization
F	0007165	biological_process	signal transduction
F	0007166	biological_process	cell surface receptor signaling pathway
F	0010507	biological_process	negative regulation of autophagy
F	0010508	biological_process	positive regulation of autophagy
F	0016020	cellular_component	membrane
F	0016055	biological_process	Wnt signaling pathway
F	0016301	molecular_function	kinase activity
F	0016607	cellular_component	nuclear speck
F	0016740	molecular_function	transferase activity
F	0019082	biological_process	viral protein processing
F	0030111	biological_process	regulation of Wnt signaling pathway
F	0030877	cellular_component	beta-catenin destruction complex
F	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F	0031669	biological_process	cellular response to nutrient levels
F	0031670	biological_process	cellular response to nutrient
F	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
F	0035025	biological_process	positive regulation of Rho protein signal transduction
F	0036064	cellular_component	ciliary basal body
F	0038202	biological_process	TORC1 signaling
F	0042995	cellular_component	cell projection
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0044546	biological_process	NLRP3 inflammasome complex assembly
F	0045095	cellular_component	keratin filament
F	0045104	biological_process	intermediate filament cytoskeleton organization
F	0051301	biological_process	cell division
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0106310	molecular_function	protein serine kinase activity
F	1900226	biological_process	negative regulation of NLRP3 inflammasome complex assembly
F	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
F	1904262	biological_process	negative regulation of TORC1 signaling
F	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGDIYlAinitngee..........VAVK

Chain	Residue	Details
C	ILE23-LYS46

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. FiHrDIKpdNFLM

Chain	Residue	Details
C	PHE132-MET144

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	216
Details	Domain: {"description":"CULT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25108355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TZ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	268
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---