8G5Z
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (S2) | 18S rRNA | polymer | 1701 | 549676.1 | 1 | Homo sapiens (human) | ||
| 2 | B (L8) | 5.8S rRNA | polymer | 156 | 50171.7 | 1 | GenBank (555853) | Homo sapiens (human) | |
| 3 | C (L5) | 28S rRNA | polymer | 3687 | 1195713.5 | 1 | Homo sapiens (human) | ||
| 4 | D (L7) | 5S rRNA | polymer | 120 | 38691.9 | 1 | GenBank (23898) | Homo sapiens (human) | |
| 5 | E (SB) | 40S ribosomal protein S3a | polymer | 223 | 25859.4 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 6 | F (SA) | 40S ribosomal protein SA | polymer | 222 | 24903.5 | 1 | UniProt (P08865) Pfam (PF00318) | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 7 | G (SD) | 40S ribosomal protein S3 | polymer | 226 | 25043.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (human) | Small ribosomal subunit protein uS3 |
| 8 | H (SJ) | 40S ribosomal protein S9 | polymer | 185 | 21649.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (human) | Small ribosomal subunit protein uS4 |
| 9 | I (SE) | eS4 | polymer | 262 | 29523.7 | 1 | Homo sapiens (human) | ||
| 10 | J (SC) | 40S ribosomal protein S2 | polymer | 222 | 24587.0 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 11 | K (SG) | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 12 | L (SF) | 40S ribosomal protein S5 | polymer | 189 | 21327.7 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (human) | Small ribosomal subunit protein uS7 |
| 13 | M (SH) | 40S ribosomal protein S7 | polymer | 189 | 21603.2 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (human) | Small ribosomal subunit protein eS7 |
| 14 | N (SW) | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (human) | Small ribosomal subunit protein uS8 |
| 15 | O (SI) | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (human) | Small ribosomal subunit protein eS8 |
| 16 | P (SQ) | uS9 | polymer | 141 | 15975.8 | 1 | Homo sapiens (human) | ||
| 17 | Q (SU) | uS10 | polymer | 101 | 11508.6 | 1 | Homo sapiens (human) | ||
| 18 | R (SK) | eS10 | polymer | 96 | 11529.7 | 1 | Homo sapiens (human) | ||
| 19 | S (SO) | uS11 | polymer | 135 | 14457.6 | 1 | Homo sapiens (human) | ||
| 20 | T (SX) | uS12 | polymer | 142 | 15729.5 | 1 | Homo sapiens (human) | ||
| 21 | U (SM) | eS12 | polymer | 122 | 13652.0 | 1 | Homo sapiens (human) | ||
| 22 | V (SS) | uS13 | polymer | 148 | 17241.0 | 1 | Homo sapiens (human) | ||
| 23 | W (Sd) | 40S ribosomal protein S29 | polymer | 55 | 6559.6 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (human) | Small ribosomal subunit protein uS14 |
| 24 | X (SN) | 40S ribosomal protein S13 | polymer | 150 | 17128.2 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (human) | Small ribosomal subunit protein uS15 |
| 25 | Y (SL) | uS17 | polymer | 143 | 16699.7 | 1 | Homo sapiens (human) | ||
| 26 | Z (SR) | 40S ribosomal protein S17 | polymer | 134 | 15447.0 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (human) | Small ribosomal subunit protein eS17 |
| 27 | AA (SP) | uS19 | polymer | 133 | 15601.4 | 1 | Homo sapiens (human) | ||
| 28 | BA (ST) | 40S ribosomal protein S19 | polymer | 143 | 15822.2 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (human) | Small ribosomal subunit protein eS19 |
| 29 | CA (SV) | 40S ribosomal protein S21 | polymer | 83 | 9166.4 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (human) | Small ribosomal subunit protein eS21 |
| 30 | DA (SY) | 40S ribosomal protein S24 | polymer | 131 | 15203.0 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (human) | Small ribosomal subunit protein eS24 |
| 31 | EA (SZ) | eS25 | polymer | 84 | 9601.5 | 1 | Homo sapiens (human) | ||
| 32 | FA (Sa) | 40S ribosomal protein S26 | polymer | 99 | 11341.4 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (human) | Small ribosomal subunit protein eS26 |
| 33 | GA (Sb) | eS27 | polymer | 83 | 9349.0 | 1 | Homo sapiens (human) | ||
| 34 | HA (Sc) | 40S ribosomal protein S28 | polymer | 64 | 7263.4 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (human) | Small ribosomal subunit protein eS28 |
| 35 | IA (Se) | 40S ribosomal protein S30 | polymer | 59 | 6668.9 | 1 | UniProt (P62861) Pfam (PF04758) | Homo sapiens (human) | Small ribosomal subunit protein eS30 |
| 36 | JA (Sf) | eS31 | polymer | 75 | 8845.5 | 1 | Homo sapiens (human) | ||
| 37 | KA (Sg) | Receptor of activated protein C kinase 1 | polymer | 313 | 34669.1 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 38 | LA (Lz) | uL1 | polymer | 211 | 24258.7 | 1 | Homo sapiens (human) | ||
| 39 | MA (LA) | uL2 | polymer | 251 | 27343.0 | 1 | Homo sapiens (human) | ||
| 40 | NA (LB) | 60S ribosomal protein L3 | polymer | 402 | 46092.9 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (human) | HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3 |
| 41 | OA (LC) | 60S ribosomal protein L4 | polymer | 368 | 41747.2 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (human) | 60S ribosomal protein L1,Large ribosomal subunit protein uL4 |
| 42 | PA (LJ) | 60S ribosomal protein L11 | polymer | 169 | 19342.4 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (human) | CLL-associated antigen KW-12,Large ribosomal subunit protein uL5 |
| 43 | QA (LH) | 60S ribosomal protein L9 | polymer | 190 | 21655.3 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (human) | Large ribosomal subunit protein uL6 |
| 44 | RA (LE) | eL6 | polymer | 223 | 25375.3 | 1 | Homo sapiens (human) | ||
| 45 | SA (LG) | 60S ribosomal protein L7a | polymer | 239 | 27224.2 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3 |
| 46 | TA (Lq) | 60S acidic ribosomal protein P0 | polymer | 196 | 21507.0 | 1 | UniProt (P05388) Pfam (PF00466) Pfam (PF17777) | Homo sapiens (human) | 60S ribosomal protein L10E,Large ribosomal subunit protein uL10 |
| 47 | UA (LK) | 60S ribosomal protein L12 | polymer | 147 | 16003.6 | 1 | UniProt (P30050) Pfam (PF03946) Pfam (PF00298) | Homo sapiens (human) | Large ribosomal subunit protein uL11 |
| 48 | VA (LO) | 60S ribosomal protein L13a | polymer | 201 | 23431.1 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (human) | 23 kDa highly basic protein,Large ribosomal subunit protein uL13 |
| 49 | WA (LL) | 60S ribosomal protein L13 | polymer | 206 | 23673.8 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (human) | Breast basic conserved protein 1,Large ribosomal subunit protein eL13 |
| 50 | XA (LV) | 60S ribosomal protein L23 | polymer | 140 | 14892.5 | 1 | UniProt (P62829) Pfam (PF00238) | Homo sapiens (human) | 60S ribosomal protein L17,Large ribosomal subunit protein uL14 |
| 51 | YA (LM) | 60S ribosomal protein L14 | polymer | 136 | 15965.0 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (human) | CAG-ISL 7,Large ribosomal subunit protein eL14 |
| 52 | ZA (La) | 60S ribosomal protein L27a | polymer | 147 | 16488.3 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (human) | Large ribosomal subunit protein uL15 |
| 53 | AB (LN) | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (human) | Large ribosomal subunit protein eL15 |
| 54 | BB (LI) | 60S ribosomal protein L10 | polymer | 205 | 23682.9 | 1 | UniProt (P27635) Pfam (PF00252) | Homo sapiens (human) | Laminin receptor homolog,Large ribosomal subunit protein uL16,Protein QM,Ribosomal protein L10,Tumor suppressor QM |
| 55 | CB (LD) | 60S ribosomal protein L5 | polymer | 294 | 34079.4 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (human) | Large ribosomal subunit protein uL18 |
| 56 | DB (LQ) | 60S ribosomal protein L18 | polymer | 187 | 21556.5 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (human) | Large ribosomal subunit protein eL18 |
| 57 | EB (LR) | 60S ribosomal protein L19 | polymer | 187 | 22441.0 | 1 | UniProt (P84098) Pfam (PF01280) Pfam (PF25476) | Homo sapiens (human) | Large ribosomal subunit protein eL19 |
| 58 | FB (LS) | 60S ribosomal protein L18a | polymer | 176 | 20808.5 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (human) | Large ribosomal subunit protein eL20 |
| 59 | GB (LT) | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (human) | Large ribosomal subunit protein eL21 |
| 60 | HB (LP) | 60S ribosomal protein L17 | polymer | 153 | 17757.6 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (human) | 60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1 |
| 61 | IB (LU) | 60S ribosomal protein L22 | polymer | 99 | 11481.2 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (human) | EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22 |
| 62 | JB (LX) | uL23 | polymer | 118 | 13727.2 | 1 | Homo sapiens (human) | ||
| 63 | KB (LY) | 60S ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (human) | Large ribosomal subunit protein uL24 |
| 64 | LB (LW) | eL24 | polymer | 118 | 13719.1 | 1 | Homo sapiens (human) | ||
| 65 | MB (LZ) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (human) | Large ribosomal subunit protein eL27 |
| 66 | NB (Lr) | 60S ribosomal protein L28 | polymer | 125 | 14362.9 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (human) | Large ribosomal subunit protein eL28 |
| 67 | OB (Lh) | 60S ribosomal protein L35 | polymer | 122 | 14462.4 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (human) | Large ribosomal subunit protein uL29 |
| 68 | PB (Lb) | eL29 | polymer | 109 | 12643.1 | 1 | Homo sapiens (human) | ||
| 69 | QB (LF) | 60S ribosomal protein L7 | polymer | 225 | 26590.7 | 1 | UniProt (P18124) Pfam (PF00327) Pfam (PF08079) | Homo sapiens (human) | Large ribosomal subunit protein uL30 |
| 70 | RB (Lc) | 60S ribosomal protein L30 | polymer | 98 | 10954.9 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL30 |
| 71 | SB (Ld) | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 1 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (human) | Large ribosomal subunit protein eL31 |
| 72 | TB (Le) | 60S ribosomal protein L32 | polymer | 128 | 15022.0 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (human) | Large ribosomal subunit protein eL32 |
| 73 | UB (Lf) | 60S ribosomal protein L35a | polymer | 109 | 12433.5 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (human) | Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33 |
| 74 | VB (Lg) | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (human) | Large ribosomal subunit protein eL34 |
| 75 | WB (Li) | 60S ribosomal protein L36 | polymer | 102 | 11915.4 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (human) | Large ribosomal subunit protein eL36 |
| 76 | XB (Lj) | 60S ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (human) | G1.16,Large ribosomal subunit protein eL37 |
| 77 | YB (Lk) | 60S ribosomal protein L38 | polymer | 69 | 8107.8 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (human) | Large ribosomal subunit protein eL38 |
| 78 | ZB (Ll) | 60S ribosomal protein L39 | polymer | 50 | 6295.6 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (human) | Large ribosomal subunit protein eL39 |
| 79 | AC (Lm) | eL40 | polymer | 52 | 6241.7 | 1 | Homo sapiens (human) | ||
| 80 | BC (Ln) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | HG12,Large ribosomal subunit protein eL41 |
| 81 | CC (Lo) | Ribosomal protein L36a | polymer | 105 | 12358.8 | 1 | UniProt (J3KQN4) Pfam (PF00935) | Homo sapiens (human) | |
| 82 | DC (Lp) | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (human) | Large ribosomal subunit protein eL43 |
| 83 | EC (mR) | mRNA | polymer | 11 | 3468.1 | 1 | Homo sapiens | ||
| 84 | FC (At) | A-site tRNA Phe | polymer | 76 | 24634.9 | 1 | GenBank (1850831943) | Escherichia coli | |
| 85 | GC (Pt) | P-site tRNA fMet | polymer | 77 | 24848.9 | 1 | GenBank (1841332652) | Escherichia coli | |
| 86 | HC (5A) | eIF5A1 | polymer | 143 | 15716.1 | 1 | Homo sapiens (human) | ||
| 87 | IC (EF) | Elongation factor 1-alpha 1 | polymer | 444 | 48519.8 | 1 | UniProt (P68105) Pfam (PF00009) Pfam (PF03144) Pfam (PF22594) | Homo sapiens (human) | EF-1-alpha-1,Elongation factor Tu,EF-Tu,Eukaryotic elongation factor 1 A-1,eEF1A-1 |
| 88 | FH, GH, HH, IH, JC... (L5, S2) | SPERMIDINE | non-polymer | 145.2 | 10 | Chemie (SPD) | |||
| 89 | AI, AJ, BI, CI, DI... (L5, Lf, S2, mR, LA...) | POTASSIUM ION | non-polymer | 39.1 | 45 | Chemie (K) | |||
| 90 | AD, AE, AF, AG, AH... (S2, L8, L5, L7, LS...) | MAGNESIUM ION | non-polymer | 24.3 | 433 | Chemie (MG) | |||
| 91 | EH (L5) | ANISOMYCIN | non-polymer | 265.3 | 1 | Chemie (ANM) | |||
| 92 | OH, PH, QH, RH, SH... (L5) | 1,4-DIAMINOBUTANE | non-polymer | 88.2 | 8 | Chemie (PUT) | |||
| 93 | WH (L5) | 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione | non-polymer | 457.6 | 1 | Chemie (3H3) | |||
| 94 | GV, JV, KU, LV, MV... (Lg, Lj, Sd, Lm, Lo...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 95 | RV (At) | PHENYLALANINE | non-polymer | 165.2 | 1 | Chemie (PHE) | |||
| 96 | UV (Pt) | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) | |||
| 97 | VV (EF) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) | |||
| 98 | WV (EF) | plitidepsin | non-polymer | 1110.3 | 1 | Chemie (ZIY) | |||
| 99 | AW, BW, CW, DW, EW... (L8, L5, L7, SE, SS...) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
SB: 2 - 234 (UniProt: P61247)
LI: 2 - 214 (UniProt: P27635)
| PDB | External Database | Details |
|---|---|---|
| - | Lys 11 | deletion |
| - | Gly 12 | deletion |
| - | Gly 13 | deletion |
| - | Lys 14 | deletion |
| - | Lys 15 | deletion |
| - | Gly 16 | deletion |
| - | Ala 17 | deletion |
| - | Lys 18 | deletion |
| - | Lys 19 | deletion |
| - | Lys 20 | deletion |
| PDB | External Database | Details |
|---|---|---|
| - | Cys 105 | deletion |
| - | Ala 106 | deletion |
| - | Gly 107 | deletion |
| - | Ala 108 | deletion |
| - | Asp 109 | deletion |
| - | Arg 110 | deletion |
| - | Leu 111 | deletion |
| - | Gln 112 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 87 |
| Total formula weight | 3330765.0 | |
| Non-Polymers* | Number of molecules | 510 |
| Total formula weight | 17651.3 | |
| All* | Total formula weight | 3348416.3 |
