8G5Z
mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (S2) | 18S rRNA | polymer | 1701 | 549676.1 | 1 | Homo sapiens (human) | ||
| 2 | B (L8) | 5.8S rRNA | polymer | 156 | 50171.7 | 1 | GenBank (555853) | Homo sapiens (human) | |
| 3 | C (L5) | 28S rRNA | polymer | 3687 | 1195713.5 | 1 | Homo sapiens (human) | ||
| 4 | D (L7) | 5S rRNA | polymer | 120 | 38691.9 | 1 | GenBank (23898) | Homo sapiens (human) | |
| 5 | E (SB) | 40S ribosomal protein S3a | polymer | 223 | 25859.4 | 1 | UniProt (P61247) Pfam (PF01015) | Homo sapiens (human) | Small ribosomal subunit protein eS1,v-fos transformation effector protein,Fte-1 |
| 6 | F (SA) | 40S ribosomal protein SA | polymer | 222 | 24903.5 | 1 | UniProt (P08865) Pfam (PF00318) | Homo sapiens (human) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Colon carcinoma laminin-binding protein,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40,Multidrug resistance-associated protein MGr1-Ag,NEM/1CHD4,Small ribosomal subunit protein uS2 |
| 7 | G (SD) | 40S ribosomal protein S3 | polymer | 226 | 25043.4 | 1 | UniProt (P23396) Pfam (PF07650) Pfam (PF00189) | Homo sapiens (human) | Small ribosomal subunit protein uS3 |
| 8 | H (SJ) | 40S ribosomal protein S9 | polymer | 185 | 21649.6 | 1 | UniProt (P46781) Pfam (PF00163) Pfam (PF01479) | Homo sapiens (human) | Small ribosomal subunit protein uS4 |
| 9 | I (SE) | eS4 | polymer | 262 | 29523.7 | 1 | Homo sapiens (human) | ||
| 10 | J (SC) | 40S ribosomal protein S2 | polymer | 222 | 24587.0 | 1 | UniProt (P15880) Pfam (PF00333) Pfam (PF03719) | Homo sapiens (human) | 40S ribosomal protein S4,Protein LLRep3,Small ribosomal subunit protein uS5 |
| 11 | K (SG) | 40S ribosomal protein S6 | polymer | 237 | 27471.5 | 1 | UniProt (P62753) Pfam (PF01092) | Homo sapiens (human) | Phosphoprotein NP33,Small ribosomal subunit protein eS6 |
| 12 | L (SF) | 40S ribosomal protein S5 | polymer | 189 | 21327.7 | 1 | UniProt (P46782) Pfam (PF00177) | Homo sapiens (human) | Small ribosomal subunit protein uS7 |
| 13 | M (SH) | 40S ribosomal protein S7 | polymer | 189 | 21603.2 | 1 | UniProt (P62081) Pfam (PF01251) | Homo sapiens (human) | Small ribosomal subunit protein eS7 |
| 14 | N (SW) | 40S ribosomal protein S15a | polymer | 129 | 14734.4 | 1 | UniProt (P62244) Pfam (PF00410) | Homo sapiens (human) | Small ribosomal subunit protein uS8 |
| 15 | O (SI) | 40S ribosomal protein S8 | polymer | 206 | 24003.0 | 1 | UniProt (P62241) Pfam (PF01201) | Homo sapiens (human) | Small ribosomal subunit protein eS8 |
| 16 | P (SQ) | uS9 | polymer | 141 | 15975.8 | 1 | Homo sapiens (human) | ||
| 17 | Q (SU) | uS10 | polymer | 101 | 11508.6 | 1 | Homo sapiens (human) | ||
| 18 | R (SK) | eS10 | polymer | 96 | 11529.7 | 1 | Homo sapiens (human) | ||
| 19 | S (SO) | uS11 | polymer | 135 | 14457.6 | 1 | Homo sapiens (human) | ||
| 20 | T (SX) | uS12 | polymer | 142 | 15729.5 | 1 | Homo sapiens (human) | ||
| 21 | U (SM) | eS12 | polymer | 122 | 13652.0 | 1 | Homo sapiens (human) | ||
| 22 | V (SS) | uS13 | polymer | 148 | 17241.0 | 1 | Homo sapiens (human) | ||
| 23 | W (Sd) | 40S ribosomal protein S29 | polymer | 55 | 6559.6 | 1 | UniProt (P62273) Pfam (PF00253) | Homo sapiens (human) | Small ribosomal subunit protein uS14 |
| 24 | X (SN) | 40S ribosomal protein S13 | polymer | 150 | 17128.2 | 1 | UniProt (P62277) Pfam (PF08069) Pfam (PF00312) | Homo sapiens (human) | Small ribosomal subunit protein uS15 |
| 25 | Y (SL) | uS17 | polymer | 143 | 16699.7 | 1 | Homo sapiens (human) | ||
| 26 | Z (SR) | 40S ribosomal protein S17 | polymer | 134 | 15447.0 | 1 | UniProt (P08708) Pfam (PF00833) | Homo sapiens (human) | Small ribosomal subunit protein eS17 |
| 27 | AA (SP) | uS19 | polymer | 133 | 15601.4 | 1 | Homo sapiens (human) | ||
| 28 | BA (ST) | 40S ribosomal protein S19 | polymer | 143 | 15822.2 | 1 | UniProt (P39019) Pfam (PF01090) | Homo sapiens (human) | Small ribosomal subunit protein eS19 |
| 29 | CA (SV) | 40S ribosomal protein S21 | polymer | 83 | 9166.4 | 1 | UniProt (P63220) Pfam (PF01249) | Homo sapiens (human) | Small ribosomal subunit protein eS21 |
| 30 | DA (SY) | 40S ribosomal protein S24 | polymer | 131 | 15203.0 | 1 | UniProt (P62847) Pfam (PF01282) | Homo sapiens (human) | Small ribosomal subunit protein eS24 |
| 31 | EA (SZ) | eS25 | polymer | 84 | 9601.5 | 1 | Homo sapiens (human) | ||
| 32 | FA (Sa) | 40S ribosomal protein S26 | polymer | 99 | 11341.4 | 1 | UniProt (P62854) Pfam (PF01283) | Homo sapiens (human) | Small ribosomal subunit protein eS26 |
| 33 | GA (Sb) | eS27 | polymer | 83 | 9349.0 | 1 | Homo sapiens (human) | ||
| 34 | HA (Sc) | 40S ribosomal protein S28 | polymer | 64 | 7263.4 | 1 | UniProt (P62857) Pfam (PF01200) | Homo sapiens (human) | Small ribosomal subunit protein eS28 |
| 35 | IA (Se) | 40S ribosomal protein S30 | polymer | 59 | 6668.9 | 1 | UniProt (P62861) Pfam (PF04758) | Homo sapiens (human) | Small ribosomal subunit protein eS30 |
| 36 | JA (Sf) | eS31 | polymer | 75 | 8845.5 | 1 | Homo sapiens (human) | ||
| 37 | KA (Sg) | Receptor of activated protein C kinase 1 | polymer | 313 | 34669.1 | 1 | UniProt (P63244) Pfam (PF00400) | Homo sapiens (human) | Cell proliferation-inducing gene 21 protein,Guanine nucleotide-binding protein subunit beta-2-like 1,Guanine nucleotide-binding protein subunit beta-like protein 12.3,Human lung cancer oncogene 7 protein,HLC-7,Receptor for activated C kinase,Small ribosomal subunit protein RACK1 |
| 38 | LA (Lz) | uL1 | polymer | 211 | 24258.7 | 1 | Homo sapiens (human) | ||
| 39 | MA (LA) | uL2 | polymer | 251 | 27343.0 | 1 | Homo sapiens (human) | ||
| 40 | NA (LB) | 60S ribosomal protein L3 | polymer | 402 | 46092.9 | 1 | UniProt (P39023) Pfam (PF00297) | Homo sapiens (human) | HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3 |
| 41 | OA (LC) | 60S ribosomal protein L4 | polymer | 368 | 41747.2 | 1 | UniProt (P36578) Pfam (PF00573) Pfam (PF14374) | Homo sapiens (human) | 60S ribosomal protein L1,Large ribosomal subunit protein uL4 |
| 42 | PA (LJ) | 60S ribosomal protein L11 | polymer | 169 | 19342.4 | 1 | UniProt (P62913) Pfam (PF00281) Pfam (PF00673) | Homo sapiens (human) | CLL-associated antigen KW-12,Large ribosomal subunit protein uL5 |
| 43 | QA (LH) | 60S ribosomal protein L9 | polymer | 190 | 21655.3 | 1 | UniProt (P32969) Pfam (PF00347) | Homo sapiens (human) | Large ribosomal subunit protein uL6 |
| 44 | RA (LE) | eL6 | polymer | 223 | 25375.3 | 1 | Homo sapiens (human) | ||
| 45 | SA (LG) | 60S ribosomal protein L7a | polymer | 239 | 27224.2 | 1 | UniProt (P62424) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3 |
| 46 | TA (Lq) | 60S acidic ribosomal protein P0 | polymer | 196 | 21507.0 | 1 | UniProt (P05388) Pfam (PF00466) Pfam (PF17777) | Homo sapiens (human) | 60S ribosomal protein L10E,Large ribosomal subunit protein uL10 |
| 47 | UA (LK) | 60S ribosomal protein L12 | polymer | 147 | 16003.6 | 1 | UniProt (P30050) Pfam (PF03946) Pfam (PF00298) | Homo sapiens (human) | Large ribosomal subunit protein uL11 |
| 48 | VA (LO) | 60S ribosomal protein L13a | polymer | 201 | 23431.1 | 1 | UniProt (P40429) Pfam (PF00572) | Homo sapiens (human) | 23 kDa highly basic protein,Large ribosomal subunit protein uL13 |
| 49 | WA (LL) | 60S ribosomal protein L13 | polymer | 206 | 23673.8 | 1 | UniProt (P26373) Pfam (PF01294) | Homo sapiens (human) | Breast basic conserved protein 1,Large ribosomal subunit protein eL13 |
| 50 | XA (LV) | 60S ribosomal protein L23 | polymer | 140 | 14892.5 | 1 | UniProt (P62829) Pfam (PF00238) | Homo sapiens (human) | 60S ribosomal protein L17,Large ribosomal subunit protein uL14 |
| 51 | YA (LM) | 60S ribosomal protein L14 | polymer | 136 | 15965.0 | 1 | UniProt (P50914) Pfam (PF01929) | Homo sapiens (human) | CAG-ISL 7,Large ribosomal subunit protein eL14 |
| 52 | ZA (La) | 60S ribosomal protein L27a | polymer | 147 | 16488.3 | 1 | UniProt (P46776) Pfam (PF00828) | Homo sapiens (human) | Large ribosomal subunit protein uL15 |
| 53 | AB (LN) | 60S ribosomal protein L15 | polymer | 203 | 24076.1 | 1 | UniProt (P61313) Pfam (PF00827) | Homo sapiens (human) | Large ribosomal subunit protein eL15 |
| 54 | BB (LI) | 60S ribosomal protein L10 | polymer | 205 | 23682.9 | 1 | UniProt (P27635) Pfam (PF00252) | Homo sapiens (human) | Laminin receptor homolog,Large ribosomal subunit protein uL16,Protein QM,Ribosomal protein L10,Tumor suppressor QM |
| 55 | CB (LD) | 60S ribosomal protein L5 | polymer | 294 | 34079.4 | 1 | UniProt (P46777) Pfam (PF17144) Pfam (PF14204) | Homo sapiens (human) | Large ribosomal subunit protein uL18 |
| 56 | DB (LQ) | 60S ribosomal protein L18 | polymer | 187 | 21556.5 | 1 | UniProt (Q07020) Pfam (PF17135) | Homo sapiens (human) | Large ribosomal subunit protein eL18 |
| 57 | EB (LR) | 60S ribosomal protein L19 | polymer | 187 | 22441.0 | 1 | UniProt (P84098) Pfam (PF01280) Pfam (PF25476) | Homo sapiens (human) | Large ribosomal subunit protein eL19 |
| 58 | FB (LS) | 60S ribosomal protein L18a | polymer | 176 | 20808.5 | 1 | UniProt (Q02543) Pfam (PF01775) | Homo sapiens (human) | Large ribosomal subunit protein eL20 |
| 59 | GB (LT) | 60S ribosomal protein L21 | polymer | 159 | 18478.8 | 1 | UniProt (P46778) Pfam (PF01157) | Homo sapiens (human) | Large ribosomal subunit protein eL21 |
| 60 | HB (LP) | 60S ribosomal protein L17 | polymer | 153 | 17757.6 | 1 | UniProt (P18621) Pfam (PF00237) | Homo sapiens (human) | 60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1 |
| 61 | IB (LU) | 60S ribosomal protein L22 | polymer | 99 | 11481.2 | 1 | UniProt (P35268) Pfam (PF01776) | Homo sapiens (human) | EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22 |
| 62 | JB (LX) | uL23 | polymer | 118 | 13727.2 | 1 | Homo sapiens (human) | ||
| 63 | KB (LY) | 60S ribosomal protein L26 | polymer | 134 | 15891.8 | 1 | UniProt (P61254) Pfam (PF16906) Pfam (PF00467) | Homo sapiens (human) | Large ribosomal subunit protein uL24 |
| 64 | LB (LW) | eL24 | polymer | 118 | 13719.1 | 1 | Homo sapiens (human) | ||
| 65 | MB (LZ) | 60S ribosomal protein L27 | polymer | 135 | 15704.6 | 1 | UniProt (P61353) Pfam (PF00467) Pfam (PF01777) | Homo sapiens (human) | Large ribosomal subunit protein eL27 |
| 66 | NB (Lr) | 60S ribosomal protein L28 | polymer | 125 | 14362.9 | 1 | UniProt (P46779) Pfam (PF01778) | Homo sapiens (human) | Large ribosomal subunit protein eL28 |
| 67 | OB (Lh) | 60S ribosomal protein L35 | polymer | 122 | 14462.4 | 1 | UniProt (P42766) Pfam (PF00831) | Homo sapiens (human) | Large ribosomal subunit protein uL29 |
| 68 | PB (Lb) | eL29 | polymer | 109 | 12643.1 | 1 | Homo sapiens (human) | ||
| 69 | QB (LF) | 60S ribosomal protein L7 | polymer | 225 | 26590.7 | 1 | UniProt (P18124) Pfam (PF00327) Pfam (PF08079) | Homo sapiens (human) | Large ribosomal subunit protein uL30 |
| 70 | RB (Lc) | 60S ribosomal protein L30 | polymer | 98 | 10954.9 | 1 | UniProt (P62888) Pfam (PF01248) | Homo sapiens (human) | Large ribosomal subunit protein eL30 |
| 71 | SB (Ld) | 60S ribosomal protein L31 | polymer | 107 | 12635.7 | 1 | UniProt (P62899) Pfam (PF01198) | Homo sapiens (human) | Large ribosomal subunit protein eL31 |
| 72 | TB (Le) | 60S ribosomal protein L32 | polymer | 128 | 15022.0 | 1 | UniProt (P62910) Pfam (PF01655) | Homo sapiens (human) | Large ribosomal subunit protein eL32 |
| 73 | UB (Lf) | 60S ribosomal protein L35a | polymer | 109 | 12433.5 | 1 | UniProt (P18077) Pfam (PF01247) | Homo sapiens (human) | Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33 |
| 74 | VB (Lg) | 60S ribosomal protein L34 | polymer | 114 | 12994.6 | 1 | UniProt (P49207) Pfam (PF01199) | Homo sapiens (human) | Large ribosomal subunit protein eL34 |
| 75 | WB (Li) | 60S ribosomal protein L36 | polymer | 102 | 11915.4 | 1 | UniProt (Q9Y3U8) Pfam (PF01158) | Homo sapiens (human) | Large ribosomal subunit protein eL36 |
| 76 | XB (Lj) | 60S ribosomal protein L37 | polymer | 86 | 10090.9 | 1 | UniProt (P61927) Pfam (PF01907) | Homo sapiens (human) | G1.16,Large ribosomal subunit protein eL37 |
| 77 | YB (Lk) | 60S ribosomal protein L38 | polymer | 69 | 8107.8 | 1 | UniProt (P63173) Pfam (PF01781) | Homo sapiens (human) | Large ribosomal subunit protein eL38 |
| 78 | ZB (Ll) | 60S ribosomal protein L39 | polymer | 50 | 6295.6 | 1 | UniProt (P62891) Pfam (PF00832) | Homo sapiens (human) | Large ribosomal subunit protein eL39 |
| 79 | AC (Lm) | eL40 | polymer | 52 | 6241.7 | 1 | Homo sapiens (human) | ||
| 80 | BC (Ln) | 60S ribosomal protein L41 | polymer | 25 | 3473.5 | 1 | UniProt (P62945) Pfam (PF05162) | Homo sapiens (human) | HG12,Large ribosomal subunit protein eL41 |
| 81 | CC (Lo) | Ribosomal protein L36a | polymer | 105 | 12358.8 | 1 | UniProt (J3KQN4) Pfam (PF00935) | Homo sapiens (human) | |
| 82 | DC (Lp) | 60S ribosomal protein L37a | polymer | 91 | 10168.2 | 1 | UniProt (P61513) Pfam (PF01780) | Homo sapiens (human) | Large ribosomal subunit protein eL43 |
| 83 | EC (mR) | mRNA | polymer | 11 | 3468.1 | 1 | Homo sapiens | ||
| 84 | FC (At) | A-site tRNA Phe | polymer | 76 | 24634.9 | 1 | GenBank (1850831943) | Escherichia coli | |
| 85 | GC (Pt) | P-site tRNA fMet | polymer | 77 | 24848.9 | 1 | GenBank (1841332652) | Escherichia coli | |
| 86 | HC (5A) | eIF5A1 | polymer | 143 | 15716.1 | 1 | Homo sapiens (human) | ||
| 87 | IC (EF) | Elongation factor 1-alpha 1 | polymer | 444 | 48519.8 | 1 | UniProt (P68105) Pfam (PF00009) Pfam (PF03144) Pfam (PF22594) | Homo sapiens (human) | EF-1-alpha-1,Elongation factor Tu,EF-Tu,Eukaryotic elongation factor 1 A-1,eEF1A-1 |
| 88 | FH, GH, HH, IH, JC... (L5, S2) | SPERMIDINE | non-polymer | 145.2 | 10 | Chemie (SPD) PubChem (1102) | |||
| 89 | AI, AJ, BI, CI, DI... (L5, Lf, S2, mR, LA...) | POTASSIUM ION | non-polymer | 39.1 | 45 | Chemie (K) PubChem (813) | |||
| 90 | AD, AE, AF, AG, AH... (S2, L8, L5, L7, LS...) | MAGNESIUM ION | non-polymer | 24.3 | 433 | Chemie (MG) PubChem (888) | |||
| 91 | EH (L5) | ANISOMYCIN | non-polymer | 265.3 | 1 | Chemie (ANM) PubChem (16757827) PubChem (2199) PubChem (31549) PubChem (67553696) PubChem (1268331) PubChem (253602) PubChem (6326612) PubChem (6604369) PubChem (6553911) PubChem (6604848) PubChem (11869388) PubChem (154831927) PubChem (134860405) PubChem (157040358) | |||
| 92 | OH, PH, QH, RH, SH... (L5) | 1,4-DIAMINOBUTANE | non-polymer | 88.2 | 8 | Chemie (PUT) PubChem (1045) | |||
| 93 | WH (L5) | 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione | non-polymer | 457.6 | 1 | Chemie (3H3) PubChem (20839296) PubChem (131825) PubChem (71713396) PubChem (71713398) PubChem (85325327) PubChem (6505344) PubChem (6439383) PubChem (11669726) PubChem (127054610) PubChem (134828037) PubChem (139033291) PubChem (139586089) PubChem (146036884) PubChem (163005148) PubChem (163005149) PubChem (163005150) PubChem (171043041) PubChem (171318865) PubChem (171326249) PubChem (172013519) | |||
| 94 | GV, JV, KU, LV, MV... (Lg, Lj, Sd, Lm, Lo...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 95 | RV (At) | PHENYLALANINE | non-polymer | 165.2 | 1 | Chemie (PHE) PubChem (994) PubChem (6140) PubChem (71567) | |||
| 96 | UV (Pt) | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) PubChem (876) PubChem (6137) PubChem (84815) | |||
| 97 | VV (EF) | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE | non-polymer | 539.2 | 1 | Chemie (GSP) PubChem (135398675) PubChem (135476260) PubChem (136073095) PubChem (136440011) PubChem (137176535) PubChem (169450542) | |||
| 98 | WV (EF) | plitidepsin | non-polymer | 1110.3 | 1 | Chemie (ZIY) PubChem (177528331) PubChem (21775644) PubChem (44152164) PubChem (57858130) PubChem (59649271) PubChem (51002200) PubChem (73313844) PubChem (56928089) PubChem (59729897) PubChem (88267650) PubChem (89291447) PubChem (5459174) PubChem (121295365) PubChem (126970336) PubChem (102066673) PubChem (121296129) PubChem (9812534) PubChem (15978373) PubChem (155933048) PubChem (162822669) PubChem (166639397) PubChem (168007925) PubChem (169708120) PubChem (169816165) PubChem (172653167) PubChem (135582349) PubChem (135756323) PubChem (163341977) PubChem (164015289) PubChem (167284192) PubChem (170008191) | |||
| 99 | AW, BW, CW, DW, EW... (L8, L5, L7, SE, SS...) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
SB: 2 - 234 (UniProt: P61247)
LI: 2 - 214 (UniProt: P27635)
| PDB | External Database | Details |
|---|---|---|
| - | Lys 11 | deletion |
| - | Gly 12 | deletion |
| - | Gly 13 | deletion |
| - | Lys 14 | deletion |
| - | Lys 15 | deletion |
| - | Gly 16 | deletion |
| - | Ala 17 | deletion |
| - | Lys 18 | deletion |
| - | Lys 19 | deletion |
| - | Lys 20 | deletion |
| PDB | External Database | Details |
|---|---|---|
| - | Cys 105 | deletion |
| - | Ala 106 | deletion |
| - | Gly 107 | deletion |
| - | Ala 108 | deletion |
| - | Asp 109 | deletion |
| - | Arg 110 | deletion |
| - | Leu 111 | deletion |
| - | Gln 112 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 87 |
| Total formula weight | 3330765.0 | |
| Non-Polymers* | Number of molecules | 510 |
| Total formula weight | 17651.3 | |
| All* | Total formula weight | 3348416.3 |
