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- EMDB-29758: mRNA decoding in human is kinetically and structurally distinct f... -

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Basic information

Entry
Database: EMDB / ID: EMD-29758
TitlemRNA decoding in human is kinetically and structurally distinct from bacteria (GA state)
Map dataMain refined 3D map
Sample
  • Complex: Human ribosome 80S with P-site tRNA, A-site tRNA eEF1A and eIF5A1
    • RNA: x 5 types
    • Protein or peptide: x 79 types
  • RNA: x 2 types
  • Protein or peptide: x 1 types
  • Ligand: x 12 types
KeywordsHuman 80S / tRNA / mRNA eEF1A / eIF5A / tRNA selection / RIBOSOME
Function / homology
Function and homology information


regulation of D-erythro-sphingosine kinase activity / guanyl nucleotide binding / positive regulation by host of viral genome replication / positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / negative regulation of endoplasmic reticulum unfolded protein response / embryonic brain development / oxidized pyrimidine DNA binding / eukaryotic 80S initiation complex / response to TNF agonist / positive regulation of base-excision repair ...regulation of D-erythro-sphingosine kinase activity / guanyl nucleotide binding / positive regulation by host of viral genome replication / positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / negative regulation of endoplasmic reticulum unfolded protein response / embryonic brain development / oxidized pyrimidine DNA binding / eukaryotic 80S initiation complex / response to TNF agonist / positive regulation of base-excision repair / negative regulation of protein neddylation / protein tyrosine kinase inhibitor activity / positive regulation of respiratory burst involved in inflammatory response / translation at presynapse / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of gastrulation / axial mesoderm development / negative regulation of formation of translation preinitiation complex / nucleolus organization / ribosomal protein import into nucleus / IRE1-RACK1-PP2A complex / : / positive regulation of endodeoxyribonuclease activity / positive regulation of Golgi to plasma membrane protein transport / 90S preribosome assembly / TNFR1-mediated ceramide production / negative regulation of RNA splicing / negative regulation of DNA repair / GAIT complex / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / oxidized purine DNA binding / supercoiled DNA binding / neural crest cell differentiation / NF-kappaB complex / middle ear morphogenesis / ubiquitin-like protein conjugating enzyme binding / regulation of establishment of cell polarity / negative regulation of phagocytosis / positive regulation of ubiquitin-protein transferase activity / Formation of the ternary complex, and subsequently, the 43S complex / rRNA modification in the nucleus and cytosol / erythrocyte homeostasis / cytoplasmic side of rough endoplasmic reticulum membrane / A band / laminin receptor activity / regulation of G1 to G0 transition / alpha-beta T cell differentiation / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of translation involved in cellular response to UV / protein kinase A binding / protein-DNA complex disassembly / positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / Translation initiation complex formation / Ribosomal scanning and start codon recognition / negative regulation of ubiquitin protein ligase activity / ion channel inhibitor activity / pigmentation / mammalian oogenesis stage / positive regulation of mitochondrial depolarization / cortical actin cytoskeleton / response to aldosterone / G1 to G0 transition / homeostatic process / activation-induced cell death of T cells / lung morphogenesis / negative regulation of Wnt signaling pathway / fibroblast growth factor binding / positive regulation of T cell receptor signaling pathway / positive regulation of activated T cell proliferation / iron-sulfur cluster binding / regulation of cell division / Protein hydroxylation / negative regulation of peptidyl-serine phosphorylation / BH3 domain binding / mTORC1-mediated signalling / macrophage chemotaxis / SARS-CoV-1 modulates host translation machinery / positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator / Peptide chain elongation / monocyte chemotaxis / Selenocysteine synthesis / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of signal transduction by p53 class mediator / ubiquitin ligase inhibitor activity / Formation of a pool of free 40S subunits / phagocytic cup / Eukaryotic Translation Termination / blastocyst development / Response of EIF2AK4 (GCN2) to amino acid deficiency / SRP-dependent cotranslational protein targeting to membrane / negative regulation of respiratory burst involved in inflammatory response / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Viral mRNA Translation / protein localization to nucleus / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / L13a-mediated translational silencing of Ceruloplasmin expression / GTP hydrolysis and joining of the 60S ribosomal subunit / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / TOR signaling
Similarity search - Function
Translation elongation factor EF1A, eukaryotic/archaeal / 60s Acidic ribosomal protein / Translation elongation factor EFTu/EF1A, C-terminal / Elongation factor Tu C-terminal domain / 60S acidic ribosomal protein P0 / 40S ribosomal protein SA / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Ubiquitin-like protein FUBI / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal ...Translation elongation factor EF1A, eukaryotic/archaeal / 60s Acidic ribosomal protein / Translation elongation factor EFTu/EF1A, C-terminal / Elongation factor Tu C-terminal domain / 60S acidic ribosomal protein P0 / 40S ribosomal protein SA / 40S ribosomal protein SA, C-terminal domain / 40S ribosomal protein SA C-terminus / Ubiquitin-like protein FUBI / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / Ribosomal protein L30e / Ribosomal protein L28e / Ribosomal L15/L27a, N-terminal / 50S ribosomal protein L10, insertion domain superfamily / Ribosomal L28e/Mak16 / Ribosomal L28e protein family / 60S ribosomal protein L10P, insertion domain / Insertion domain in 60S ribosomal protein L10P / : / Tr-type G domain, conserved site / Ribosomal protein S26e signature. / Translational (tr)-type guanine nucleotide-binding (G) domain signature. / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S26e / Ribosomal protein S21e, conserved site / Ribosomal protein S21e signature. / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S19e, conserved site / Ribosomal protein S19e signature. / Small (40S) ribosomal subunit Asc1/RACK1 / Ribosomal protein S2, eukaryotic / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Ribosomal protein L22e / Ribosomal protein L22e superfamily / Ribosomal L22e protein family / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal L38e protein family / Ribosomal protein S2, eukaryotic/archaeal / : / Ribosomal protein S17e, conserved site / Ribosomal protein S17e signature. / Ribosomal protein S8e subdomain, eukaryotes / Ribosomal protein S30 / Ribosomal protein S30 / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal protein L27e, conserved site / Ribosomal protein L27e signature. / Ribosomal protein S7e signature. / Ribosomal protein L44e signature. / Ribosomal protein L10e, conserved site / Ribosomal protein L10e signature. / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal protein L10e / Ribosomal protein L13e / Ribosomal protein L13e / Ribosomal protein L19, eukaryotic / Ribosomal protein S19e / Ribosomal protein S3Ae, conserved site / Ribosomal protein S19e / Ribosomal protein S3Ae signature. / Ribosomal_S19e / 60S ribosomal protein L18a/ L20, eukaryotes / Ribosomal protein S8e, conserved site / Ribosomal protein S8e signature. / Ribosomal protein L44e / Ribosomal protein L19/L19e conserved site / Ribosomal protein L44 / Ribosomal protein L19e signature. / Ribosomal protein L34e, conserved site / Ribosomal protein L34e signature. / Ribosomal protein L5 eukaryotic, C-terminal / Ribosomal L18 C-terminal region / Ribosomal protein S17e / Ribosomal protein S17e-like superfamily / Ribosomal S17 / 50S ribosomal protein L18Ae/60S ribosomal protein L20 and L18a / Ribosomal protein L30e signature 1. / Ribosomal protein 50S-L18Ae/60S-L20/60S-L18A / Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A / Ribosomal protein S6, eukaryotic / 40S ribosomal protein S1/3, eukaryotes / Ribosomal S24e conserved site / Ribosomal protein S24e signature. / Eukaryotic Ribosomal Protein L27, KOW domain / Ribosomal protein L30e signature 2. / Ribosomal protein S7e / Translation elongation factor EFTu-like, domain 2 / Ribosomal protein L30e, conserved site / Ribosomal protein S7e / Ribosomal protein 60S L18 and 50S L18e / Ribosomal protein L27e / Ribosomal protein L27e superfamily
Similarity search - Domain/homology
Large ribosomal subunit protein eL42 / Large ribosomal subunit protein uL10 / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein eL33 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein uL22 / Small ribosomal subunit protein uS3 / Large ribosomal subunit protein eL13 ...Large ribosomal subunit protein eL42 / Large ribosomal subunit protein uL10 / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein eL33 / Large ribosomal subunit protein uL30 / Large ribosomal subunit protein uL22 / Small ribosomal subunit protein uS3 / Large ribosomal subunit protein eL13 / Large ribosomal subunit protein uL16 / Large ribosomal subunit protein uL11 / Large ribosomal subunit protein uL6 / Large ribosomal subunit protein eL22 / Large ribosomal subunit protein uL4 / Small ribosomal subunit protein eS19 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein uL13 / Large ribosomal subunit protein uL29 / Large ribosomal subunit protein uL15 / Large ribosomal subunit protein uL18 / Large ribosomal subunit protein eL21 / Large ribosomal subunit protein eL28 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Large ribosomal subunit protein eL34 / Large ribosomal subunit protein eL14 / Small ribosomal subunit protein eS1 / Large ribosomal subunit protein uL24 / Large ribosomal subunit protein eL15 / Large ribosomal subunit protein eL27 / Large ribosomal subunit protein eL43 / Large ribosomal subunit protein eL37 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS15 / Large ribosomal subunit protein eL8 / Small ribosomal subunit protein eS6 / Large ribosomal subunit protein uL14 / Small ribosomal subunit protein eS24 / Small ribosomal subunit protein eS26 / Small ribosomal subunit protein eS28 / Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein eL31 / Large ribosomal subunit protein eL32 / Large ribosomal subunit protein uL5 / Small ribosomal subunit protein eS32 / Large ribosomal subunit protein eL38 / Small ribosomal subunit protein eS21 / Small ribosomal subunit protein RACK1 / Elongation factor 1-alpha 1 / Large ribosomal subunit protein eL19 / Large ribosomal subunit protein eL20 / Large ribosomal subunit protein eL18 / Large ribosomal subunit protein eL36
Similarity search - Component
Biological speciesHomo sapiens (human) / Escherichia coli (E. coli)
Methodsingle particle reconstruction / cryo EM / Resolution: 2.64 Å
AuthorsHolm M / Natchiar KS / Rundlet EJ / Myasnikov AG / Altman RB / Blanchard SC
Funding support1 items
OrganizationGrant numberCountry
Not funded
CitationJournal: Nature / Year: 2023
Title: mRNA decoding in human is kinetically and structurally distinct from bacteria.
Authors: Mikael Holm / S Kundhavai Natchiar / Emily J Rundlet / Alexander G Myasnikov / Zoe L Watson / Roger B Altman / Hao-Yuan Wang / Jack Taunton / Scott C Blanchard /
Abstract: In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives ...In all species, ribosomes synthesize proteins by faithfully decoding messenger RNA (mRNA) nucleotide sequences using aminoacyl-tRNA substrates. Current knowledge of the decoding mechanism derives principally from studies on bacterial systems. Although key features are conserved across evolution, eukaryotes achieve higher-fidelity mRNA decoding than bacteria. In human, changes in decoding fidelity are linked to ageing and disease and represent a potential point of therapeutic intervention in both viral and cancer treatment. Here we combine single-molecule imaging and cryogenic electron microscopy methods to examine the molecular basis of human ribosome fidelity to reveal that the decoding mechanism is both kinetically and structurally distinct from that of bacteria. Although decoding is globally analogous in both species, the reaction coordinate of aminoacyl-tRNA movement is altered on the human ribosome and the process is an order of magnitude slower. These distinctions arise from eukaryote-specific structural elements in the human ribosome and in the elongation factor eukaryotic elongation factor 1A (eEF1A) that together coordinate faithful tRNA incorporation at each mRNA codon. The distinct nature and timing of conformational changes within the ribosome and eEF1A rationalize how increased decoding fidelity is achieved and potentially regulated in eukaryotic species.
History
DepositionFeb 14, 2023-
Header (metadata) releaseApr 19, 2023-
Map releaseApr 19, 2023-
UpdateNov 15, 2023-
Current statusNov 15, 2023Processing site: RCSB / Status: Released

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Structure visualization

Supplemental images

emd_29758.png

Downloads & links

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Map

FileDownload / File: emd_29758.map.gz / Format: CCP4 / Size: 1000 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
AnnotationMain refined 3D map
Voxel sizeX=Y=Z: 0.826 Å
Density
Contour LevelBy EMDB: 0.003
Minimum - Maximum-0.012440275 - 0.041203868
Average (Standard dev.)0.000052611493 (±0.0013689579)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions640640640
Spacing640640640
CellA=B=C: 528.64 Å
α=β=γ: 90.0 °

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Supplemental data

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Mask #1

Fileemd_29758_msk_1.map
Projections & Slices
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Additional map: Post-processed masked map

Fileemd_29758_additional_1.map
AnnotationPost-processed masked map
Projections & Slices
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Additional map: Post-processed unmasked map

Fileemd_29758_additional_2.map
AnnotationPost-processed unmasked map
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Additional map: Post-processed and locally filtered map

Fileemd_29758_additional_3.map
AnnotationPost-processed and locally filtered map
Projections & Slices
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Half map: Half map 2

Fileemd_29758_half_map_1.map
AnnotationHalf map 2
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Half map: Half map 1

Fileemd_29758_half_map_2.map
AnnotationHalf map 1
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Sample components

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Entire : Human ribosome 80S with P-site tRNA, A-site tRNA eEF1A and eIF5A1

EntireName: Human ribosome 80S with P-site tRNA, A-site tRNA eEF1A and eIF5A1
Components
  • Complex: Human ribosome 80S with P-site tRNA, A-site tRNA eEF1A and eIF5A1
    • RNA: 18S rRNA
    • RNA: 5.8S rRNA
    • RNA: 28S rRNA
    • RNA: 5S rRNA
    • Protein or peptide: 40S ribosomal protein S3a
    • Protein or peptide: 40S ribosomal protein SA
    • Protein or peptide: 40S ribosomal protein S3
    • Protein or peptide: 40S ribosomal protein S9
    • Protein or peptide: eS4
    • Protein or peptide: 40S ribosomal protein S2
    • Protein or peptide: 40S ribosomal protein S6
    • Protein or peptide: 40S ribosomal protein S5
    • Protein or peptide: 40S ribosomal protein S7
    • Protein or peptide: 40S ribosomal protein S15a
    • Protein or peptide: 40S ribosomal protein S8
    • Protein or peptide: uS9
    • Protein or peptide: uS10
    • Protein or peptide: eS10
    • Protein or peptide: uS11
    • Protein or peptide: uS12
    • Protein or peptide: eS12
    • Protein or peptide: uS13
    • Protein or peptide: 40S ribosomal protein S29
    • Protein or peptide: 40S ribosomal protein S13
    • Protein or peptide: uS17
    • Protein or peptide: 40S ribosomal protein S17
    • Protein or peptide: uS19
    • Protein or peptide: 40S ribosomal protein S19
    • Protein or peptide: 40S ribosomal protein S21
    • Protein or peptide: 40S ribosomal protein S24
    • Protein or peptide: eS25
    • Protein or peptide: 40S ribosomal protein S26
    • Protein or peptide: eS27
    • Protein or peptide: 40S ribosomal protein S28
    • Protein or peptide: 40S ribosomal protein S30
    • Protein or peptide: eS31
    • Protein or peptide: Receptor of activated protein C kinase 1
    • Protein or peptide: uL1
    • Protein or peptide: uL2
    • Protein or peptide: 60S ribosomal protein L3
    • Protein or peptide: 60S ribosomal protein L4
    • Protein or peptide: 60S ribosomal protein L11
    • Protein or peptide: 60S ribosomal protein L9
    • Protein or peptide: eL6
    • Protein or peptide: 60S ribosomal protein L7a
    • Protein or peptide: 60S acidic ribosomal protein P0
    • Protein or peptide: 60S ribosomal protein L12
    • Protein or peptide: 60S ribosomal protein L13a
    • Protein or peptide: 60S ribosomal protein L23
    • Protein or peptide: 60S ribosomal protein L14
    • Protein or peptide: 60S ribosomal protein L27a
    • Protein or peptide: 60S ribosomal protein L15
    • Protein or peptide: 60S ribosomal protein L10
    • Protein or peptide: 60S ribosomal protein L5
    • Protein or peptide: 60S ribosomal protein L18
    • Protein or peptide: 60S ribosomal protein L19
    • Protein or peptide: 60S ribosomal protein L18a
    • Protein or peptide: 60S ribosomal protein L21
    • Protein or peptide: 60S ribosomal protein L17
    • Protein or peptide: 60S ribosomal protein L22
    • Protein or peptide: uL23
    • Protein or peptide: 60S ribosomal protein L26
    • Protein or peptide: eL24
    • Protein or peptide: 60S ribosomal protein L27
    • Protein or peptide: 60S ribosomal protein L28
    • Protein or peptide: 60S ribosomal protein L35
    • Protein or peptide: eL29
    • Protein or peptide: 60S ribosomal protein L7
    • Protein or peptide: 60S ribosomal protein L30
    • Protein or peptide: 60S ribosomal protein L31
    • Protein or peptide: 60S ribosomal protein L32
    • Protein or peptide: 60S ribosomal protein L35a
    • Protein or peptide: 60S ribosomal protein L34
    • Protein or peptide: 60S ribosomal protein L36
    • Protein or peptide: 60S ribosomal protein L37
    • Protein or peptide: 60S ribosomal protein L38
    • Protein or peptide: 60S ribosomal protein L39
    • Protein or peptide: eL40
    • Protein or peptide: 60S ribosomal protein L41
    • Protein or peptide: Ribosomal protein L36a
    • Protein or peptide: 60S ribosomal protein L37a
    • RNA: mRNA
    • Protein or peptide: eIF5A1
    • Protein or peptide: Elongation factor 1-alpha 1
  • RNA: A-site tRNA Phe
  • RNA: P-site tRNA fMet
  • Protein or peptide: 60S ribosomal protein L13
  • Ligand: SPERMIDINE
  • Ligand: POTASSIUM ION
  • Ligand: MAGNESIUM ION
  • Ligand: ANISOMYCIN
  • Ligand: 1,4-DIAMINOBUTANE
  • Ligand: 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione
  • Ligand: ZINC ION
  • Ligand: PHENYLALANINE
  • Ligand: METHIONINE
  • Ligand: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
  • Ligand: plitidepsin
  • Ligand: water

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Supramolecule #1: Human ribosome 80S with P-site tRNA, A-site tRNA eEF1A and eIF5A1

SupramoleculeName: Human ribosome 80S with P-site tRNA, A-site tRNA eEF1A and eIF5A1
type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#48, #50-#83, #86-#87
Molecular weightTheoretical: 5.5 MDa

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Macromolecule #1: 18S rRNA

MacromoleculeName: 18S rRNA / type: rna / ID: 1 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 549.676062 KDa
SequenceString: UACCUGGUUG AUCCUGCCAG UAGCAU(A2M)UGC UUG(PSU)C(PSU)CAAA GAUUAAGCCA UGCAUGUCUA AGUACGCA C GGCCGGUACA GUGAAACUGC GAA(PSU)GGCUC(A2M) UUAAA(PSU)CAG(PSU) UAUGGU(OMU)CC(PSU) U (OMU)GGUCGCU ...String:
UACCUGGUUG AUCCUGCCAG UAGCAU(A2M)UGC UUG(PSU)C(PSU)CAAA GAUUAAGCCA UGCAUGUCUA AGUACGCA C GGCCGGUACA GUGAAACUGC GAA(PSU)GGCUC(A2M) UUAAA(PSU)CAG(PSU) UAUGGU(OMU)CC(PSU) U (OMU)GGUCGCU CGCCACUUGG AUAACUGUGG UA(A2M)UUCUAG(A2M) GCUAA(OMU)A(OMC)AU GCCGACGGGC GC UGACCCC CUUCGCGGGG GGGAUGCGUG CA(PSU)UUAUCAG UGGUGACUC(PSU) AGAUAACCUC GGGCCGAUCG CACGC CCCC CGUGGCGGCG ACGACCCAUU CGAACGUC(OMU)G CCCUAUCAAC UUUCGAUGGU AGUCGCCGUG CCUACCAUGG UG ACCACGG G(PSU)GACGGGGA AUCAGGGUUC GAU(OMU)CCGGAG A(OMG)GGAGCCUG AGAAACGGCU ACCACAU (OMC)C AAGG(A2M)AGGCA GCAGGCGCGC (A2M)AAUUACCCA CUCCCGACCC GGGGA(OMG)GU(A2M)G UGA(OMC) GAAAA AUAACAAUAC AGGACUCUUU CGAGGCCCUG UAAUUGGAAU GAGUCCACU(PSU) (PSU)AA(A2M)UCCUUU AAC GAGG(A2M)U CCAUUGGAG(OMG) GCAAGUC(PSU)GG UGCCAGCAGC CGCGG(OMU)AAUU CCAGCUCCAA UA(OMG)C GUA(PSU)A (PSU)UAAAGUUGC UGCAGUU(A2M)AA AAGCUCGUAG (PSU)U(OMG)GA(PSU)CUUG GGAGCGGGCG U CCCCGCCU U(PSU)ACUUUGAA AAAA(PSU)(PSU)AGAG UG(PSU)UCAAAGC AGGCCCGAGC CGCCUGGAUA CCGCAG CUA GGAA(PSU)AA(PSU)(OMG)G AAUAGGACCG CGGUUCUAUU UUGUUGGUUU UCGGAACUGA GGCCAUGAU(PSU) A AGAGGGAC GGCCGGGGGC AUUCGUAUUG CGCCGCUAGA GGUGAAAU(PSU)C UUGGACCGGC GCAAGACGGA CCAGAGCG A AAGCAUU(PSU)GC CAAGAAUGUU UUCAUUAAUC AAGA(A2M)CGAAA GUCGGAGGUU CGAAGACGA(PSU) CAGAUAC CG UCGUAGUUCC GACCA(PSU)AAAC GAUGCCGACC GGCGAUGCGG CGGCGUUAUU CCCAUGACCC GCCGGGCAGC (PSU)UCCGGGAA ACCAAAGUCU UUGGGUUCCG GGGGGAGUA(PSU) GG(PSU)UGCAAAG CUGAAACUUA AAGGAAUUG ACGGAAGGGC ACCACCAGGA GUGGAGCC(PSU)G CGGC(PSU)(PSU)AAU(PSU) (PSU)GAC(B8N)CAACA CGGGAA ACC UCACCCGGCC CGGACACGGA CAGGA(OMU)UGAC AGAUUGAUAG CUCUUUCUCG AUUCCGUGGG UGG(UY1)G (OMG)UGC AUGGC(4AC)GUUC UUAGU(PSU)GGUG GAGCGAUUUG UCUGG(PSU)UAAU UCCGAUAACG A(A2M)CGAG ACU (OMC)UGGCAUGCU AACUAGUUAC GCGACCCCCG AGCGGUCGGC GUCCCCCAAC U(OMU)CU(PSU)A(OMG)AGG G ACAAGUGG CGUUCAGCCA CCCGAGAUUG AGCAAUAACA (OMG)GUCUGUGAU GCCCUUAGAU GUCCGGGGCU GCACGCGC G CUACACUGAC UGGCUCAGCG UGUGCCUACC CUACGCCGGC AGGCGCGGGU AACCCGUUGA ACCCCAUUCG UGAUGGGGA UCGGGGAUUG CAAUUAU(PSU)CC CCAUGAACGA G(G7M)AAU(PSU)CCCA GUAAGUGCGG GUCAUAAGCU UGCGUUGA U U(A2M)AGUCCCUG CCCUU(PSU)GUAC ACACCG(OMC)CCG UCGCUACUAC CGAUUGGAUG GUUUAGUGAG GCCCUCG GA UCGGCCCCGC CGGGGUGCCC UGGCGGAGCG CUGAGAAGAC GGUCGAACU(OMU) GACUAUCUAG AGGAAGUAAA AGUC GUA(6MZ)C AAGGUUUC(4AC)G UAGGUG(MA6)(MA6)CC UGCGGAAGGA UCAUUA

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Macromolecule #2: 5.8S rRNA

MacromoleculeName: 5.8S rRNA / type: rna / ID: 2 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 50.171703 KDa
SequenceString:
CGACUCUUAG CGG(OMU)GGAUCA CUCGGCUCGU GCGUCGAUGA AGAACGCAGC UAGC(PSU)GCGAG AAUUAAUG (PSU) GAAUU(OMG)CAGG ACACAUUGAU CAUCGACACU UCGAACGCAC UUGCGGCCCC GGGUUCCUCC CGGGGCUACG C CUGUCUGA GCGUCGCU

GENBANK: GENBANK: U13369.1

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Macromolecule #3: 28S rRNA

MacromoleculeName: 28S rRNA / type: rna / ID: 3 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 1.1957134999999999 MDa
SequenceString: CGCGACCUCA GAUCAGACGU GGCGACCCGC UGAAUUUAAG CAUAUUAGUC AGCGGAGGAG AAGAAACUAA CCAGGAUUCC CUCAGUAAC GGCGAGUGAA CAGGGAAGAG CCCAGCGCCG AAUCCCCGCC CCGCGGCGGG GCGCGGGACA UGUGGCGUAC G GAAGACCC ...String:
CGCGACCUCA GAUCAGACGU GGCGACCCGC UGAAUUUAAG CAUAUUAGUC AGCGGAGGAG AAGAAACUAA CCAGGAUUCC CUCAGUAAC GGCGAGUGAA CAGGGAAGAG CCCAGCGCCG AAUCCCCGCC CCGCGGCGGG GCGCGGGACA UGUGGCGUAC G GAAGACCC GCUCCCCGGC GCCGCUCGUG GGGGGCCCAA GUCCUUCUGA UCGAGGCCCA GCCCGUGGAC GGUGUGAGGC CG GUAGCGG CCCCCGGCGC GCCGGGCCCG GGUCUUCCCG GAGUCGGGUU GCUUGGGAAU GCAGCCCAAA GCGGGUGGUA AAC UCCAUC UAAGGCUAAA UACCGGCACG AGACCGAUAG UCAACAAGUA CCGUAAGGGA AAGUUGAAAA GAACUUUGAA G (A2M)G(A2M)GAGUU CAAGAGGGCG UGAAACCGUU AAGAGGUAAA CGGGUGGGGU CCGCGCAGUC CGCCCGGAGG AUUC AACCC GGCGGCGGGU CCGGCCGUGU CGGCGCGGCG GAUCUUUCCC GCGGGGGACC GUCCCCCGAC CGGCGACCGG CCGCC GCCG GGCGCAUUUC CACCGCGGCG GUGCGCCGCG ACCGGCUCCG GGACGGCUGG GAAGGCCCGG CGGGGAAGGU GGCUCG GGG GCCCCCGAGU GUUACAGCCC CCCCGGCAGC AGCACUCGCC GAAUCCCGGG GCCGAGGGAG CGAGACCCGU CGCCGCG CU CUCCCCCCUG GGGGGGCCGG GCCACCCCUC CCACGGCGCG ACCGCUCGGG GCGGACUGUC CCCAGUGCGC CCCGGGCG G GUCGCGCCGU CGGGCCCGGG GGGCCACGCG CGCGUCCCCC GAAGAGGGGG ACGGCGGAGC GAGCGCACGG GGUCGGCGG CGACGUCGGC UACCCACCCG ACCC(OMG)UCUUG (1MA)AAC(A2M)CGGAC CAAGGAGU(OMC)U AACACGUGCG CGAG UCGGG GGCUCGCACG AAAGCCGCCG UGGCGCAAUG AAGGUGAAGG CCGGCGCGCU CGCCGGCCGA GGUGGGAUCC CGAGG CCUC UCCAGUCCGC CGAGGGCGCA CCACCGGCCC GUCUCGCCCG CCGCGCCGGG GAGGUGGAGC ACGAGCGCAC GUGUUA GGA CCC(OMG)A(A2M)AGAU GGUGA(A2M)C(PSU)AU GCCUGGGCAG GGCGAAGCCA GAGGAAACUC UGGUGGAGGU C CG(PSU)AGCGG UCCUGACGUG CAAAUCGGUC GUCCGACCUG GGUAUAG(OMG)GG CGAAAGACUA AUCGAACCAU CUAG UAGCU GGUUCCCUCC GAAGUUUCCC (PSU)CAGGA(PSU)AGC UGGCGCUCUC GCAGACCCGA ACGCAGUUUU AUCCGGU AA AGCGAA(PSU)GAU UAGAGGUCUU GGGGCCGAAA CGAUCUCAAC C(PSU)A(PSU)(PSU)CUCAA ACUU(PSU)AAA U GGGUAAGAAG CCCGGCUCGC UGGCGUGGAG CCGGGCGUGG AAUGCGAGUG CCUAGUGGGC CAC(PSU)U(PSU)UGGU A AGC(A2M)GAAC UGGCG(OMC)UGCG GGAUGAACCG AACGCCGGGU UAAGGCGCCC GAUGCCGACG CUCAUCAGAC CCCA GAAAA GGUGUUGGUU GAUAUAGACA GCAGGACGGU GGCCAUGGAA GUCGGAAUCC GCUAAGGAGU GUGUAACAAC UCACC UGCC GAAUCAACUA GCCCUGAAAA UGGAUGGCGC UGGAGCGUCG GGCCCAUACC CGGCCGUCGC CGGCAGUCGA GAGUGG ACG GGAGCGGCGG GCCGGAGCCC CGCGGACGCU ACGCCGCGAC GAGUAGGAGG GCCGCUGCGG UGAGCCUUGA AGCCUAG GG CGCGGGCCCG GGUGGAGCCG CCGCAGGUGC AGAU(OMC)UUGGU GGUAGU(A2M)(OMG)(OMC)A AAUAUUCAAA CG AGAACUU UGAAGGCCGA AGUGG(A2M)GAAG GGUUCCAUG(OMU) GAACAG(OMC)A(OMG)U UGAACAUGGG UCAGUCG GU CCUGAGAGAU GGGCGAGCGC CGUUCCGAAG GGACGGGCGA UGGCCUCCGU UGCCCUCGGC CGA(PSU)CGAAAG GGAG UCGGG UUCAGAUCCC CGAAUCCGGA GCGGAGAUGG GCGCCGCGAG GCGUCCAGUG CGGUAACGCG ACCGAUCCCG GAGAA GCCG GCGGGAGCCC CGGGGAGAGU UCUCUU(PSU)UCU UUGUGAAGGG CAGGGCGCCC UGGAAUGGGU UCGCCCCGAG AG AGGGGCC CGUGCCUUGG AAAGCGUCGC GGUUCCGGCG GCGUCCGGUG AGCUCUCGCU GGCCCUUGAA AAUCCGGGGG AGA GGGUGU AAAUCUCGCG CCGGGCCGUA CCC(A2M)UAUCCG CAGCAGGUCU (OMC)CAAGGUGAA C(A2M)GCCUCUGG (OMC)AUGUUGGA ACAA(OMU)G(PSU)AGG (PSU)AAGGGAAGU CGGCAAGC(OMC)G GAUCCGUAAC UUC(OMG)GGA UA AGGAUUGGCU CUAAGGGCUG GGUCGGUCGC GGCCGGCGCC UAGCAGCCGA CUUAGAACUG GUGCGGACCA GG(OMG)G AAUCC GAC(PSU)G(PSU)UUAA UUAAAACAAA GCAUCGCGAA GGCCCGCGGC GGGUGUUGAC GCGAUGUGAU U(PSU)C UGCC(OMC)A GUGCUCUGAA UG(PSU)CA(A2M)AGUG (A2M)(A2M)GAAA(PSU)UCA A(PSU)GAAGCGCG G(OMG) UAAACGG CGGGAG(PSU)A(A2M)C (PSU)A(PSU)GAC(PSU)C(PSU)C UUAAGGUAGC (5MC)AA(A2M)UGCCUC (OMG)UCAUCUAA UUAGUGA(OMC)GC GCAUGAA(UY1)GG AUGA(A2M)CGAG(A2M) UUCCCACUGU (OMC)CC (PSU)ACCUA C(PSU)A(PSU)CCAGCG AAACCAC(A2M)G(OMC) CAAGGGAACG GGCU(PSU)GG(OMC)GG AAUCAG CGG (OMG)GAAAGAAGA CCCUGUUGAG C(PSU)UGAC(OMU)CUA GUCUGGCACG GUGAA(OMG)AGAC AUGAGAGGUG U AGAAUAAG UGGGAGGCCC GGGCCGCCGG UGAAAUACCA CUACUCUGAU CGUUUUUUCA CUGACCCGGU GAGGCGGGGG GG CGAGCCC CGAGGGGCUC UCGCUUCUGG CGCCAAGCGC CCGGCCGCGC GCCGGCCGGG CGCGACCCGC UCCGGGGACA GUG CCAGGU GGGGAGUUUG ACUG(OMG)GGCGG UACACCUGUC AAACGGUA(6MZ)C GCAGG(OMU)(OMG)UCC UAAGGCGA G CUCAGGGAGG ACAGAAACCU CCCGUGGAGC AGAAGGGCAA AAGCUCGCUU GA(PSU)CU(PSU)GA(PSU)U UUCAG (OMU)ACG AA(PSU)ACAGACC GUGAAAGCGG GGCCUCACGA UCCUUCUGAC CUU(PSU)UGGGUU U(PSU)AAGCAGGA (OMG)GUGUCAGA AAAGUUACCA CAG(OMG)GAUAAC UGGC(PSU)UGUGG CGGCCAAGCG U(PSU)CA(PSU)AGCGA C G(PSU)CGCUUU UUGA(PSU)CCUU(5MC) GAUGUCGG(OMC)(PSU) CUUCCUAUCA UUG(PSU)GAAGCA GAAUUCAC C AAGCGU(PSU)(OMG)GA U(OMU)(OMG)(PSU)UCACCC ACUAAUAGGG AACG(PSU)G(A2M)GCU GGG(UR3) (PSU)(PSU)AGA (OMC)CGUCGUGAG ACAGGU(PSU)AGU UUUACCCUAC UGA(PSU)G(A2M)UGUG (PSU)UG (PSU)UGCCA UGGUA(A2M)UCCU GCUCAGUACG AGAGGAACCG CAG(OMG)U(OMU)CA(OMG)A CAU(PSU)UGGUGU A(PSU)(OMG)UGCUUG GCUGAGGAGC CAAUGGGGCG AAGCUACCA(PSU) CUGUGGGAUU AUGAC(PSU)GAAC GCCUC UAAG UCAGAAUCCC GCCCAGGCGG AACGAUACGG CAGCGCCGCG GAGCCUCGGU UGGCCUCGGA UAGCCGGUCC CCCGCC GGG GUCCGGUGCG GAGUGCCCUU CGUCCUGGGA AACGGGGCGC GGCCGGAGAG GCGGCCGCCC CCUCGCCCGU CACGCAC CG CACGUUCGUG GGGAACCUGG CGCUAAACCA (PSU)UCGUAGACG ACCUGCUUCU GGGUCGGGG(PSU) UUCGUACG (PSU) AGCAGAGCAG CUCCCUCGCU GCGAUCUAUU GAAAGUCAGC CCUCGACACA AGGGUUUGU

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Macromolecule #4: 5S rRNA

MacromoleculeName: 5S rRNA / type: rna / ID: 4 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 38.691914 KDa
SequenceString:
GUCUACGGCC AUACCACCCU GAACGCGCCC GAUCUCGUCU GAUCUCGGAA GCUAAGCAGG GUCGGGCCUG GUUAGUACUU GGAUGGGAG ACCGCCUGGG AAUACCGGGU GCUGUAGGCU U

GENBANK: GENBANK: X12811.1

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Macromolecule #83: mRNA

MacromoleculeName: mRNA / type: rna / ID: 83 / Number of copies: 1
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 3.468098 KDa
SequenceString:
CGUAUGUUCA A

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Macromolecule #84: A-site tRNA Phe

MacromoleculeName: A-site tRNA Phe / type: rna / ID: 84 / Number of copies: 1
Source (natural)Organism: Escherichia coli (E. coli)
Molecular weightTheoretical: 24.634879 KDa
SequenceString:
GCCCGGA(4SU)AG CUCAG(H2U)CGG(H2U) AGAGCAGGGG A(PSU)UGAA(MIA)A(PSU)C CCCGU(G7M)UCCU UG GUUCGAU UCCGAGUCCG GGCACCA

GENBANK: GENBANK: CP026929.2

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Macromolecule #85: P-site tRNA fMet

MacromoleculeName: P-site tRNA fMet / type: rna / ID: 85 / Number of copies: 1
Source (natural)Organism: Escherichia coli (E. coli)
Molecular weightTheoretical: 24.848943 KDa
SequenceString:
CGCGGGG(4SU)GG AGCAGCCCGG (H2U)AGCUCGUCG GG(OMC)UCAUAAC CCGAAG(G7M)UCG UCGGU(PSU)CAAA UCCGGCCCC CGCAACCA

GENBANK: GENBANK: CP053231.1

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Macromolecule #5: 40S ribosomal protein S3a

MacromoleculeName: 40S ribosomal protein S3a / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 25.859438 KDa
SequenceString: AVGKNKRLTV VDPFSKKDWY DVKAPAMFNI RNIGKTLVTR TQGTKIASDG LKGRVFEVSL ADLQNDEVAF RKFKLITEDV QGKNCLTNF HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI RKTSYAQHQQ VRQIRKKMME I MTREVQTN ...String:
AVGKNKRLTV VDPFSKKDWY DVKAPAMFNI RNIGKTLVTR TQGTKIASDG LKGRVFEVSL ADLQNDEVAF RKFKLITEDV QGKNCLTNF HGMDLTRDKM CSMVKKWQTM IEAHVDVKTT DGYLLRLFCV GFTKKRNNQI RKTSYAQHQQ VRQIRKKMME I MTREVQTN DLKEVVNKLI PDSIGKDIEK ACQSIYPLHD VFVRKVKMLK KPKFELGKLM ELHGE

UniProtKB: Small ribosomal subunit protein eS1

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Macromolecule #6: 40S ribosomal protein SA

MacromoleculeName: 40S ribosomal protein SA / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.903479 KDa
SequenceString: (SAC)GALDVLQMK EEDVLKFLAA GTHLGGTNLD FQMEQYIYKR KSDGIYIINL KRTWEKLLLA ARAIVAIENP ADVSVI SSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYV DI AIPCNNKGAH ...String:
(SAC)GALDVLQMK EEDVLKFLAA GTHLGGTNLD FQMEQYIYKR KSDGIYIINL KRTWEKLLLA ARAIVAIENP ADVSVI SSR NTGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYV DI AIPCNNKGAH SVGLMWWMLA REVLRMRGTI SREHPWEVMP DLYFYRDPEE IEKEEQAAAE KAVT

UniProtKB: Small ribosomal subunit protein uS2

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Macromolecule #7: 40S ribosomal protein S3

MacromoleculeName: 40S ribosomal protein S3 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO / EC number: DNA-(apurinic or apyrimidinic site) lyase
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 25.043381 KDa
SequenceString: MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAE KVATRGLCAI AQAESLRYKL LGGLAVRRAC YGVLRFIMES GAKGCEVVVS GKLRGQRAKS MKFVDGLMIH S GDPVNYYV ...String:
MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG EKGRRIRELT AVVQKRFGFP EGSVELYAE KVATRGLCAI AQAESLRYKL LGGLAVRRAC YGVLRFIMES GAKGCEVVVS GKLRGQRAKS MKFVDGLMIH S GDPVNYYV DTAVRHVLLR QGVLGIKVKI MLPWDPTGKI GPKKPLPDHV SIVEPKDEIL PTTPISEQ

UniProtKB: Small ribosomal subunit protein uS3

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Macromolecule #8: 40S ribosomal protein S9

MacromoleculeName: 40S ribosomal protein S9 / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.649633 KDa
SequenceString:
PVARSWVCRK TYVTPRRPFE KSRLDQELKL IGEYGLRNKR EVWRVKFTLA KIRKAARELL TLDEKDPRRL FEGNALLRRL VRIGVLDEG KMKLDYILGL KIEDFLERRL QTQVFKLGLA KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR LDSQKHIDFS L RSPYGGGR PGRVKRKNAK KGQGGAG

UniProtKB: Small ribosomal subunit protein uS4

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Macromolecule #9: eS4

MacromoleculeName: eS4 / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 29.523674 KDa
SequenceString: ARGPKKHLKR VAAPKHWMLD KLTGVFAPRP STGPHKLREC LPLIIFLRNR LKYALTGDEV KKICMQRFIK IDGKVRTDIT YPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI Q IDLETGKI ...String:
ARGPKKHLKR VAAPKHWMLD KLTGVFAPRP STGPHKLREC LPLIIFLRNR LKYALTGDEV KKICMQRFIK IDGKVRTDIT YPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI Q IDLETGKI TDFIKFDTGN LCMVTGGANL GRIGVITNRE RHPGSFDVVH VKDANGNSFA TRLSNIFVIG KGNKPWISLP RG KGIRLTI AEERDKRLAA KQSSG

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Macromolecule #10: 40S ribosomal protein S2

MacromoleculeName: 40S ribosomal protein S2 / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.587029 KDa
SequenceString: EWMPVTKLGR LVKDMKIKSL EEIYLFSLPI KESEIIDFFL GASLKDEVLK IMPVQKQTRA GQRTRFKAFV AIGDYNGHVG LGVKCSKEV ATAIRGAIIL AKLSIVPVRR GYWGNKIGKP HTVPCKVTGR CGSVLVRLIP APRGTGIVSA PVPKKLLMMA G IDDCYTSA ...String:
EWMPVTKLGR LVKDMKIKSL EEIYLFSLPI KESEIIDFFL GASLKDEVLK IMPVQKQTRA GQRTRFKAFV AIGDYNGHVG LGVKCSKEV ATAIRGAIIL AKLSIVPVRR GYWGNKIGKP HTVPCKVTGR CGSVLVRLIP APRGTGIVSA PVPKKLLMMA G IDDCYTSA RGCTATLGNF AKATFDAISK TYSYLTPDLW KETVFTKSPY QEFTDHLVKT HTRV

UniProtKB: Small ribosomal subunit protein uS5

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Macromolecule #11: 40S ribosomal protein S6

MacromoleculeName: 40S ribosomal protein S6 / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 27.471535 KDa
SequenceString: MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRT GERKRKSVRG CIVDANLSVL NLVIVKKGEK DIPGLTDTTV PRRLGPKRAS RIRKLFNLSK EDDVRQYVVR K PLNKEGKK ...String:
MKLNISFPAT GCQKLIEVDD ERKLRTFYEK RMATEVAADA LGEEWKGYVV RISGGNDKQG FPMKQGVLTH GRVRLLLSKG HSCYRPRRT GERKRKSVRG CIVDANLSVL NLVIVKKGEK DIPGLTDTTV PRRLGPKRAS RIRKLFNLSK EDDVRQYVVR K PLNKEGKK PRTKAPKIQR LVTPRVLQHK RRRIALKKQR TKKNKEEAAE YAKLLAKRMK EAKEKRQEQI AKRRRLSSL

UniProtKB: Small ribosomal subunit protein eS6

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Macromolecule #12: 40S ribosomal protein S5

MacromoleculeName: 40S ribosomal protein S5 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.327723 KDa
SequenceString:
DIKLFGKWST DDVQINDISL QDYIAVKEKY AKYLPHSAGR YAAKRFRKAQ CPIVERLTNS MMMHGRNNGK KLMTVRIVKH AFEIIHLLT GENPLQVLVN AIINSGPRED STRIGRAGTV RRQAVDVSPL RRVNQAIWLL CTGAREAAFR NIKTIAECLA D ELINAAKG SSNSYAIKKK DELERVAKSN R

UniProtKB: Small ribosomal subunit protein uS7

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Macromolecule #13: 40S ribosomal protein S7

MacromoleculeName: 40S ribosomal protein S7 / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.603229 KDa
SequenceString:
SAKIVKPNGE KPDEFESGIS QALLELEMNS DLKAQLRELN ITAAKEIEVG GGRKAIIIFV PVPQLKSFQK IQVRLVRELE KKFSGKHVV FIAQRRILPK PTRKSRTKNK QKRPRSRTLT AVHDAILEDL VFPSEIVGKR IRVKLDGSRL IKVHLDKAQQ N NVEHKVET FSGVYKKLTG KDVNFEFPEF Q

UniProtKB: Small ribosomal subunit protein eS7

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Macromolecule #14: 40S ribosomal protein S15a

MacromoleculeName: 40S ribosomal protein S15a / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 14.734357 KDa
SequenceString:
VRMNVLADAL KSINNAEKRG KRQVLIRPCS KVIVRFLTVM MKHGYIGEFE IIDDHRAGKI VVNLTGRLNK CGVISPRFDV QLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH TGGKILGFFF

UniProtKB: Small ribosomal subunit protein uS8

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Macromolecule #15: 40S ribosomal protein S8

MacromoleculeName: 40S ribosomal protein S8 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.003012 KDa
SequenceString: GISRDNWHKR RKTGGKRKPY HKKRKYELGR PAANTKIGPR RIHTVRVRGG NKKYRALRLD VGNFSWGSEC CTRKTRIIDV VYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS L LEEQFQQG ...String:
GISRDNWHKR RKTGGKRKPY HKKRKYELGR PAANTKIGPR RIHTVRVRGG NKKYRALRLD VGNFSWGSEC CTRKTRIIDV VYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS L LEEQFQQG KLLACIASRP GQCGRADGYV LEGKELEFYL RKIKARKG

UniProtKB: Small ribosomal subunit protein eS8

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Macromolecule #16: uS9

MacromoleculeName: uS9 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.975753 KDa
SequenceString:
PLQSVQVFGR KKTATAVAHC KRGNGLIKVN GRPLEMIEPR TLQYKLLEPV LLLGKERFAG VDIRVRVKGG GHVAQIYAIR QSISKALVA YYQKYVDEAS KKEIKDILIQ YDRTLLVADP RRCESKKFGG PGARARYQKS YR

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Macromolecule #17: uS10

MacromoleculeName: uS10 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.508648 KDa
SequenceString:
IHRIRITLTS RNVKSLEKVC ADLIRGAKEK NLKVKGPVRM PTKTLRITTR KTPCGEGSKT WDRFQMRIHK RLIDLHSPSE IVKQITSIS IEPGVEVEVT IA

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Macromolecule #18: eS10

MacromoleculeName: eS10 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.529682 KDa
SequenceString:
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEI VPATLRR

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Macromolecule #19: uS11

MacromoleculeName: uS11 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 14.45758 KDa
SequenceString:
LGPQVAEGEN VFGVCHIFAS FNDTFVHVTD LSGKETICRV TGGMKVKADR DESSPYAAML AAQDVAQRCK ELGITALHIK LRATGGNRT KTPGPGAQSA LRALARSGMK IGRIEDVTPI PSDSTRRKGG RRGRRL

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Macromolecule #20: uS12

MacromoleculeName: uS12 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.72947 KDa
SequenceString:
GKCRGLRTAR KLRSHRRDQK WHDKQYKKAH LGTALKANPF GGASHAKGIV LEKVGVEAKQ (HY3)NSAIRKCVR VQLIKN GKK ITAFVPNDGC LNFIEENDEV LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS

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Macromolecule #21: eS12

MacromoleculeName: eS12 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.652019 KDa
SequenceString:
VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC VLASNCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGK PRKVVGCSCV VVKDYGKESQ AKDVIEEYFK CKK

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Macromolecule #22: uS13

MacromoleculeName: uS13 / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 17.241041 KDa
SequenceString:
SLVIPEKFQH ILRVLNTNID GRRKIAFAIT AIKGVGRRYA HVVLRKADID LTKRAGELTE DEVERVITIM QNPRQYKIPD WFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVS

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Macromolecule #23: 40S ribosomal protein S29

MacromoleculeName: 40S ribosomal protein S29 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 6.559625 KDa
SequenceString:
GHQQLYWSHP RKFGQGSRSC RVCSNRHGLI RKYGLNMCRQ CFRQYAKDIG FIKLD

UniProtKB: Small ribosomal subunit protein uS14

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Macromolecule #24: 40S ribosomal protein S13

MacromoleculeName: 40S ribosomal protein S13 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 17.128191 KDa
SequenceString:
GRMHAPGKGL SQSALPYRRS VPTWLKLTSD DVKEQIYKLA KKGLTPSQIG VILRDSHGVA QVRFVTGNKI LRILKSKGLA PDLPEDLYH LIKKAVAVRK HLERNRKDKD AKFRLILIES RIHRLARYYK TKRVLPPNWK YESSTASALV A

UniProtKB: Small ribosomal subunit protein uS15

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Macromolecule #25: uS17

MacromoleculeName: uS17 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 16.69973 KDa
SequenceString:
ADIQTERAYQ KQPTIFQNKK RVKLPRYYKN IGLGFKTPKE AIEGTYIDKK CPFTGNVSIR GRILSGVVTK MKMQRTIVIR RDYLHYIRK YNRFEKRHKN MSVHLSPCFR DVQIGDIVTV GECRPLSKTV RFNVLKVTKA AGTK

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Macromolecule #26: 40S ribosomal protein S17

MacromoleculeName: 40S ribosomal protein S17 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.446961 KDa
SequenceString:
GRVRTKTVKK AARVIIEKYY TRLGNDFHTN KRVCEEIAII PSKKLRNKIA GYVTHLMKRI QRGPVRGISI KLQEEERERR DNYVPEVSA LDQEIIEVDP DTKEMLKLLD FGSLSNLQVT QPTVGMNFKT PRGPV

UniProtKB: Small ribosomal subunit protein eS17

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Macromolecule #27: uS19

MacromoleculeName: uS19 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.601372 KDa
SequenceString:
TFRKFTYRGV DLDQLLDMSY EQLMQLYSAR QRRRLNRGLR RKQHSLLKRL RKAKKEAPPM EKPEVVKTHL RDMIILPEMV GSMVGVYNG KTFNQVEIKP EMIGHYLGEF SITYKPVKHG RPGIGATHSS RFIP

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Macromolecule #28: 40S ribosomal protein S19

MacromoleculeName: 40S ribosomal protein S19 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.822219 KDa
SequenceString:
PGVTVKDVNQ QEFVRALAAF LKKSGKLKVP EWVDTVKLAK HKELAPYDEN WFYTRAASTA RHLYLRGGAG VGSMTKIYGG RQRNGVMPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKK

UniProtKB: Small ribosomal subunit protein eS19

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Macromolecule #29: 40S ribosomal protein S21

MacromoleculeName: 40S ribosomal protein S21 / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 9.166426 KDa
SequenceString:
(AME)QNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR RMGESDDSIL RLAKAD GIV SKNF

UniProtKB: Small ribosomal subunit protein eS21

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Macromolecule #30: 40S ribosomal protein S24

MacromoleculeName: 40S ribosomal protein S24 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.203022 KDa
SequenceString:
NDTVTIRTRK FMTNRLLQRK QMVIDVLHPG KATVPKTEIR EKLAKMYKTT PDVIFVFGFR THFGGGKTTG FGMIYDSLDY AKKNEPKHR LARHGLYEKK KTSRKQRKER KNRMKKVRGT AKANVGAGKK PK

UniProtKB: Small ribosomal subunit protein eS24

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Macromolecule #31: eS25

MacromoleculeName: eS25 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 9.601491 KDa
SequenceString:
KKKWSKGKVR DKLNNLVLFD KATYDKLCKE VPNYKLITPA VVSERLKIRG SLARAALQEL LSKGLIKLVS KHRAQVIYTR NTKG

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Macromolecule #32: 40S ribosomal protein S26

MacromoleculeName: 40S ribosomal protein S26 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.341426 KDa
SequenceString:
TKKRRNNGRA KKGRGHVQPI RCTNCARCVP KDKAIKKFVI RNIVEAAAVR DISEASVFDA YVLPKLYVKL HYCVSCAIHS KVVRNRSRE ARKDRTPPPR

UniProtKB: Small ribosomal subunit protein eS26

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Macromolecule #33: eS27

MacromoleculeName: eS27 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 9.34899 KDa
SequenceString:
PLAKDLLHPS PEEEKRKHKK KRLVQSPNSY FMDVKCPGCY KITTVFSHAQ TVVLCVGCST VLCQPTGGKA RLTEGCSFRR KQH

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Macromolecule #34: 40S ribosomal protein S28

MacromoleculeName: 40S ribosomal protein S28 / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 7.263394 KDa
SequenceString:
RVQPIKLARV TKVLGRTGSQ GQCTQVRVEF MDDTSRSIIR NVKGPVREGD VLTLLESERE ARRL

UniProtKB: Small ribosomal subunit protein eS28

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Macromolecule #35: 40S ribosomal protein S30

MacromoleculeName: 40S ribosomal protein S30 / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 6.668938 KDa
SequenceString:
KVHGSLARAG KVRGQTPKVA KQEKKKKKTG RAKRRMQYNR RFVNVVPTFG KKKGPNANS

UniProtKB: Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

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Macromolecule #36: eS31

MacromoleculeName: eS31 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 8.845535 KDa
SequenceString:
AKKRKKKSYT TPKKNKHKRK KVKLAVLKYY KVDENGKISR LRRECPSDEC GAGVFMASHF DRHYCGKCCL TYCFN

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Macromolecule #37: Receptor of activated protein C kinase 1

MacromoleculeName: Receptor of activated protein C kinase 1 / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 34.669113 KDa
SequenceString: TEQMTLRGTL KGHNGWVTQI ATTPQFPDMI LSASRDKTII MWKLTRDETN YGIPQRALRG HSHFVSDVVI SSDGQFALSG SWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS S NPIIVSCG ...String:
TEQMTLRGTL KGHNGWVTQI ATTPQFPDMI LSASRDKTII MWKLTRDETN YGIPQRALRG HSHFVSDVVI SSDGQFALSG SWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS S NPIIVSCG WDKLVKVWNL ANCKLKTNHI GHTGYLNTVT VSPDGSLCAS GGKDGQAMLW DLNEGKHLYT LDGGDIINAL CF SPNRYWL CAATGPSIKI WDLEGKIIVD ELKQEVISTS SKAEPPQCTS LAWSADGQTL FAGYTDNLVR VWQVTI

UniProtKB: Small ribosomal subunit protein RACK1

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Macromolecule #38: uL1

MacromoleculeName: uL1 / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.25868 KDa
SequenceString: RDTLYEAVRE VLHGNQRKRR KFLETVELQI SLKNYDPQKD KRFSGTVRLK STPRPKFSVC VLGDQQHCDE AKAVDIPHMD IEALKKLNK NKKLVKKLAK KYDAFLASES LIKQIPRILG PGLNKAGKFP SLLTHNENMV AKVDEVKSTI KFQMKKVLCL A VAVGHVKM ...String:
RDTLYEAVRE VLHGNQRKRR KFLETVELQI SLKNYDPQKD KRFSGTVRLK STPRPKFSVC VLGDQQHCDE AKAVDIPHMD IEALKKLNK NKKLVKKLAK KYDAFLASES LIKQIPRILG PGLNKAGKFP SLLTHNENMV AKVDEVKSTI KFQMKKVLCL A VAVGHVKM TDDELVYNIH LAVNFLVSLL KKNWQNVRAL YIKSTMGKPQ RLY

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Macromolecule #39: uL2

MacromoleculeName: uL2 / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 27.34302 KDa
SequenceString: GRVIRGQRKG AGSVFRAHVK HRKGAARLRA VDFAERHGYI KGIVKDIIHD PGRGAPLAKV VFRDPYRFKK RTELFIAAEG IHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS A NRAVVGVV ...String:
GRVIRGQRKG AGSVFRAHVK HRKGAARLRA VDFAERHGYI KGIVKDIIHD PGRGAPLAKV VFRDPYRFKK RTELFIAAEG IHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS A NRAVVGVV AGGGRIDKPI LKAGRAYHKY KAKRNCWPRV RGVAMNPVEH PFGGGN(V5N)QHI GKPSTIRRDA PAGRKVGL I AARRTGRLRG TKTV

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Macromolecule #40: 60S ribosomal protein L3

MacromoleculeName: 60S ribosomal protein L3 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 46.092938 KDa
SequenceString: SHRKFSAPRH GSLGFLPRKR SSRHRGKVKS FPKDDPSKPV HLTAFLGYKA GMTHIVREVD RPGSKVNKKE VVEAVTIVET PPMVVVGIV GYVETPRGLR TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDE DGKKQLEKDF SSMKKYCQVI R VIAHTQMR ...String:
SHRKFSAPRH GSLGFLPRKR SSRHRGKVKS FPKDDPSKPV HLTAFLGYKA GMTHIVREVD RPGSKVNKKE VVEAVTIVET PPMVVVGIV GYVETPRGLR TFKTVFAEHI SDECKRRFYK NWHKSKKKAF TKYCKKWQDE DGKKQLEKDF SSMKKYCQVI R VIAHTQMR LLPLRQKKAH LMEIQVNGGT VAEKLDWARE RLEQQVPVNQ VFGQDEMIDV IGVTKGKGYK GVTSRWHTKK LP RKT(HIC)RGL RKVACIGAWH PARVAFSVAR AGQKGYHHRT EINKKIYKIG QGYLIKDGKL IKNNASTDYD LSDKSINPL GGFVHYGEVT NDFVMLKGCV VGTKKRVLTL RKSLLVQTKR RALEKIDLKF IDTTSKFGHG RFQTMEEKKA FMGPLKKDRI AKEEGA

UniProtKB: Large ribosomal subunit protein uL3

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Macromolecule #41: 60S ribosomal protein L4

MacromoleculeName: 60S ribosomal protein L4 / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 41.747203 KDa
SequenceString: MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQ GAFGNMCRGG RMFAPTKTWR RWHRRVNTTQ KRYAICSALA ASALPALVMS KGHRIEEVPE LPLVVEDKVE G YKKTKEAV ...String:
MACARPLISV YSEKGESSGK NVTLPAVFKA PIRPDIVNFV HTNLRKNNRQ PYAVSELAGH QTSAESWGTG RAVARIPRVR GGGTHRSGQ GAFGNMCRGG RMFAPTKTWR RWHRRVNTTQ KRYAICSALA ASALPALVMS KGHRIEEVPE LPLVVEDKVE G YKKTKEAV LLLKKLKAWN DIKKVYASQR MRAGKGKMRN RRRIQRRGPC IIYNEDNGII KAFRNIPGIT LLNVSKLNIL KL APGGHVG RFCIWTESAF RKLDELYGTW RKAASLKSNY NLPMHKMINT DLSRILKSPE IQRALRAPRK KIHRRVLKKN PLK NLRIML KLNPYAKTMR RNTILRQARN HKLRVDKAAA AAAALQAKSD EK

UniProtKB: Large ribosomal subunit protein uL4

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Macromolecule #42: 60S ribosomal protein L11

MacromoleculeName: 60S ribosomal protein L11 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 19.342447 KDa
SequenceString:
KENPMRELRI RKLCLNICVG ESGDRLTRAA KVLEQLTGQT PVFSKARYTV RSFGIRRNEK IAVHCTVRGA KAEEILEKGL KVREYELRK NNFSDTGNFG FGIQEHIDLG IKYDPSIGIY GLDFYVVLGR PGFSIADKKR RTGCIGAKHR ISKEEAMRWF Q QKYDGIIL P

UniProtKB: Large ribosomal subunit protein uL5

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Macromolecule #43: 60S ribosomal protein L9

MacromoleculeName: 60S ribosomal protein L9 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.655268 KDa
SequenceString:
MKTILSNQTV DIPENVDITL KGRTVIVKGP RGTLRRDFNH INVELSLLGK KKKRLRVDKW WGNRKELATV RTICSHVQNM IKGVTLGFR YKMRSVYAHF PINVVIQENG SLVEIRNFLG EKYIRRVRMR PGVACSVSQA QKDELILEGN DIELVSNSAA L IQQATTVK NKDIRKFLDG IYVSEKGTVQ QA

UniProtKB: Large ribosomal subunit protein uL6

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Macromolecule #44: eL6

MacromoleculeName: eL6 / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 25.375318 KDa
SequenceString: KGKPHCSRNP VLVRGIGRYS RSAMYSRKAM YKRKYSAAVL ATVTKPVGGD KNGGTRVVKL RKMPRYYPTE DVPRKLLSHG KKPFSQHVR KLRASITPGT ILIILTGRHR GKRVVFLKQL ASGLLLVTGP LVLNRVPLRR THQKFVIATS TKIDISNVKI P KHLTDAYF ...String:
KGKPHCSRNP VLVRGIGRYS RSAMYSRKAM YKRKYSAAVL ATVTKPVGGD KNGGTRVVKL RKMPRYYPTE DVPRKLLSHG KKPFSQHVR KLRASITPGT ILIILTGRHR GKRVVFLKQL ASGLLLVTGP LVLNRVPLRR THQKFVIATS TKIDISNVKI P KHLTDAYF KKKKEKYEIT EQRKIDQKAV DSQILPKIKA IPQLQGYLRS VFALTNGIYP HKLVF

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Macromolecule #45: 60S ribosomal protein L7a

MacromoleculeName: 60S ribosomal protein L7a / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 27.224193 KDa
SequenceString: VNPLFEKRPK NFGIGQDIQP KRDLTRFVKW PRYIRLQRQR AILYKRLKVP PAINQFTQAL DRQTATQLLK LAHKYRPETK QEKKQRLLA RAEKKAAGKG DVPTKRPPVL RAGVNTVTTL VENKKAQLVV IAHDVDPIEL VVFLPALCRK MGVPYCIIKG K ARLGRLVH ...String:
VNPLFEKRPK NFGIGQDIQP KRDLTRFVKW PRYIRLQRQR AILYKRLKVP PAINQFTQAL DRQTATQLLK LAHKYRPETK QEKKQRLLA RAEKKAAGKG DVPTKRPPVL RAGVNTVTTL VENKKAQLVV IAHDVDPIEL VVFLPALCRK MGVPYCIIKG K ARLGRLVH RKTCTTVAFT QVNSEDKGAL AKLVEAIRTN YNDRYDEIRR HWGGNVLGPK SVARIAKLEK AKAKELATKL G

UniProtKB: Large ribosomal subunit protein eL8

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Macromolecule #46: 60S acidic ribosomal protein P0

MacromoleculeName: 60S acidic ribosomal protein P0 / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.507035 KDa
SequenceString: DRATWKSNYF LKIIQLLDDY PKCFIVGADN VGSKQMQQIR MSLRGKAVVL MGKNTMMRKA IRGHLENNPA LEKLLPHIRG NVGFVFTKE DLTEIRDMLL ANKVPAAARA GAIAPCEVTV PAQNTGLGPE KTSFFQALGI TTKISRGTIE ILSDVQLIKT G DKVGASEA ...String:
DRATWKSNYF LKIIQLLDDY PKCFIVGADN VGSKQMQQIR MSLRGKAVVL MGKNTMMRKA IRGHLENNPA LEKLLPHIRG NVGFVFTKE DLTEIRDMLL ANKVPAAARA GAIAPCEVTV PAQNTGLGPE KTSFFQALGI TTKISRGTIE ILSDVQLIKT G DKVGASEA TLLNMLNISP FSFGLVIQQV FDNGSIYN

UniProtKB: Large ribosomal subunit protein uL10

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Macromolecule #47: 60S ribosomal protein L12

MacromoleculeName: 60S ribosomal protein L12 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 16.003562 KDa
SequenceString:
EIKVVYLRCT GGEVGATSAL APKIGPLGLS PKKVGDDIAK ATGDWKGLRI TVKLTIQNRQ AQIEVVPSAS ALIIKALKEP PRDRKKQKN IKHSGNITFD EIVNIARQMR HRSLARELSG TIKEILGTAQ SVGCNVDGRH PHDIIDDI

UniProtKB: Large ribosomal subunit protein uL11

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Macromolecule #48: 60S ribosomal protein L13a

MacromoleculeName: 60S ribosomal protein L13a / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 23.431139 KDa
SequenceString: EVQVLVLDGR GHLLGRLAAI VAKQVLLGRK VVVVRCEGIN ISGNFYRNKL KYLAFLRKRM NTNPSRGPYH FRAPSRIFWR TVRGMLPHK TKRGQAALDR LKVFDGIPPP YDKKKRMVVP AALKVVRLKP TRKFAYLGRL AHEVGWKYQA VTATLEEKRK E KAKIHYRK ...String:
EVQVLVLDGR GHLLGRLAAI VAKQVLLGRK VVVVRCEGIN ISGNFYRNKL KYLAFLRKRM NTNPSRGPYH FRAPSRIFWR TVRGMLPHK TKRGQAALDR LKVFDGIPPP YDKKKRMVVP AALKVVRLKP TRKFAYLGRL AHEVGWKYQA VTATLEEKRK E KAKIHYRK KKQLMRLRKQ AEKNVEKKID KYTEVLKTHG LLV

UniProtKB: Large ribosomal subunit protein uL13

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Macromolecule #49: 60S ribosomal protein L13

MacromoleculeName: 60S ribosomal protein L13 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 23.67383 KDa
SequenceString: APSRNGMVLK PHFHKDWQRR VATWFNQPAR KIRRRKARQA KARRIAPRPA SGPIRPIVRC PTVRYHTKVR AGRGFSLEEL RVAGIHKKV ARTIGISVDP RRRNKSTESL QANVQRLKEY RSKLILFPRK PSAPKKGDSS AEELKLATQL TGPVMPVRNV Y KKEKARVI ...String:
APSRNGMVLK PHFHKDWQRR VATWFNQPAR KIRRRKARQA KARRIAPRPA SGPIRPIVRC PTVRYHTKVR AGRGFSLEEL RVAGIHKKV ARTIGISVDP RRRNKSTESL QANVQRLKEY RSKLILFPRK PSAPKKGDSS AEELKLATQL TGPVMPVRNV Y KKEKARVI TEEEKNFKAF ASLRMARANA RLFGIRAKRA KEAAEQDV

UniProtKB: Large ribosomal subunit protein eL13

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Macromolecule #50: 60S ribosomal protein L23

MacromoleculeName: 60S ribosomal protein L23 / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 14.892505 KDa
SequenceString:
MSKRGRGGSS GAKFRISLGL PVGAVINCAD NTGAKNLYII SVKGIKGRLN RLPAAGVGDM VMATVKKGKP ELRKKVHPAV VIRQRKSYR RKDGVFLYFE DNAGVIVNNK GEMKGSAITG PVAKECADLW PRIASNAGSI A

UniProtKB: Large ribosomal subunit protein uL14

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Macromolecule #51: 60S ribosomal protein L14

MacromoleculeName: 60S ribosomal protein L14 / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.965036 KDa
SequenceString:
VFRRFVEVGR VAYVSFGPHA GKLVAIVDVI DQNRALVDGP CTQVRRQAMP FKCMQLTDFI LKFPHSAHQK YVRQAWQKAD INTKWAATR WAKKIEARER KAKMTDFDRF KVMKAKKMRN RIIKNEVKKL QKAALLK

UniProtKB: Large ribosomal subunit protein eL14

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Macromolecule #52: 60S ribosomal protein L27a

MacromoleculeName: 60S ribosomal protein L27a / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 16.48833 KDa
SequenceString:
PSRLRKTRKL RGHVSHGHGR IGKHRKHPGG RGNAGGL(V5N)HH RINFDKYHPG YFGKVGMKHY HLKRNQSFCP TVNLDK LWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ PVIVKAKFFS RRAEEKIKSV GGACVLVA

UniProtKB: Large ribosomal subunit protein uL15

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Macromolecule #53: 60S ribosomal protein L15

MacromoleculeName: 60S ribosomal protein L15 / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 24.076088 KDa
SequenceString: GAYKYIQELW RKKQSDVMRF LLRVRCWQYR QLSALHRAPR PTRPDKARRL GYKAKQGYVI YRIRVRRGGR KRPVPKGATY GKPVHHGVN QLKFARSLQS VAEERAGRHC GALRVLNSYW VGEDSTYKFF EVILIDPFHK AIRRNPDTQW ITKPVHKHRE M RGLTSAGR ...String:
GAYKYIQELW RKKQSDVMRF LLRVRCWQYR QLSALHRAPR PTRPDKARRL GYKAKQGYVI YRIRVRRGGR KRPVPKGATY GKPVHHGVN QLKFARSLQS VAEERAGRHC GALRVLNSYW VGEDSTYKFF EVILIDPFHK AIRRNPDTQW ITKPVHKHRE M RGLTSAGR KSRGLGKGHK FHHTIGGSRR AAWRRRNTLQ LHRYR

UniProtKB: Large ribosomal subunit protein eL15

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Macromolecule #54: 60S ribosomal protein L10

MacromoleculeName: 60S ribosomal protein L10 / type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 23.682945 KDa
SequenceString: GRRPARCYRY CKNKPYPKSR FCRGVPDAKI RIFDLGRKKA KVDEFPLCGH MVSDEYEQLS SEALEAARIC ANKYMVKSCG KDGFHIRVR LHPFHVIRIN KMLSTGMRGA FGKPQGTVAR VHIGQVIMSI RTKLQNKEHV IEALRRAKFK FPGRQKIHIS K KWGFTKFN ...String:
GRRPARCYRY CKNKPYPKSR FCRGVPDAKI RIFDLGRKKA KVDEFPLCGH MVSDEYEQLS SEALEAARIC ANKYMVKSCG KDGFHIRVR LHPFHVIRIN KMLSTGMRGA FGKPQGTVAR VHIGQVIMSI RTKLQNKEHV IEALRRAKFK FPGRQKIHIS K KWGFTKFN ADEFEDMVAE KRLIPDGCGV KYIPSRGPLD KWRALHS

UniProtKB: Large ribosomal subunit protein uL16

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Macromolecule #55: 60S ribosomal protein L5

MacromoleculeName: 60S ribosomal protein L5 / type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 34.079402 KDa
SequenceString: GFVKVVKNKA YFKRYQVKFR RRREGKTDYY ARKRLVIQDK NKYNTPKYRM IVRVTNRDII CQIAYARIEG DMIVCAAYAH ELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE GQVEVTGDEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF G ALKGAVDG ...String:
GFVKVVKNKA YFKRYQVKFR RRREGKTDYY ARKRLVIQDK NKYNTPKYRM IVRVTNRDII CQIAYARIEG DMIVCAAYAH ELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE GQVEVTGDEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF G ALKGAVDG GLSIPHSTKR FPGYDSESKE FNAEVHRKHI MGQNVADYMR YLMEEDEDAY KKQFSQYIKN SVTPDMMEEM YK KAHAAIR ENPVYEKKPK KEVKKKRWNR PKMSLAQKKD RVAQKKASFL RAQERAA

UniProtKB: Large ribosomal subunit protein uL18

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Macromolecule #56: 60S ribosomal protein L18

MacromoleculeName: 60S ribosomal protein L18 / type: protein_or_peptide / ID: 56 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 21.556482 KDa
SequenceString:
GVDIRHNKDR KVRRKEPKSQ DIYLRLLVKL YRFLARRTNS TFNQVVLKRL FMSRTNRPPL SLSRMIRKMK LPGRENKTAV VVGTITDDV RVQEVPKLKV CALRVTSRAR SRILRAGGKI LTFDQLALDS PKGCGTVLLS GPRKGREVYR HFGKAPGTPH S HTKPYVRS KGRKFERARG RRASRGYKN

UniProtKB: Large ribosomal subunit protein eL18

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Macromolecule #57: 60S ribosomal protein L19

MacromoleculeName: 60S ribosomal protein L19 / type: protein_or_peptide / ID: 57 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 22.441021 KDa
SequenceString:
SMLRLQKRLA SSVLRCGKKK VWLDPNETNE IANANSRQQI RKLIKDGLII RKPVTVHSRA RCRKNTLARR KGRHMGIGKR KGTANARMP EKVTWMRRMR ILRRLLRRYR ESKKIDRHMY HSLYLKVKGN VFKNKRILME HIHKLKADKA RKKLLADQAE A RRSKTKEA RKRREERLQA KKEEIIKTL

UniProtKB: Large ribosomal subunit protein eL19

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Macromolecule #58: 60S ribosomal protein L18a

MacromoleculeName: 60S ribosomal protein L18a / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 20.808514 KDa
SequenceString:
MKASGTLREY KVVGRCLPTP KCHTPPLYRM RIFAPNHVVA KSRFWYFVSQ LKKMKKSSGE IVYCGQVFEK SPLRVKNFGI WLRYDSRSG THNMYREYRD LTTAGAVTQC YRDMGARHRA RAHSIQIMKV EEIAASKCRR PAVKQFHDSK IKFPLPHRVL R RQHKPRFT TKRPNTFF

UniProtKB: Large ribosomal subunit protein eL20

+
Macromolecule #59: 60S ribosomal protein L21

MacromoleculeName: 60S ribosomal protein L21 / type: protein_or_peptide / ID: 59 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 18.478791 KDa
SequenceString:
TNTKGKRRGT RYMFSRPFRK HGVVPLATYM RIYKKGDIVD IKGMGTVQKG MPHKCYHGKT GRVYNVTQHA VGIVVNKQVK GKILAKRIN VRIEHIKHSK SRDSFLKRVK ENDQKKKEAK EKGTWVQLKR QPAPPREAHF VRTNGKEPEL LEPIPYEFMA

UniProtKB: Large ribosomal subunit protein eL21

+
Macromolecule #60: 60S ribosomal protein L17

MacromoleculeName: 60S ribosomal protein L17 / type: protein_or_peptide / ID: 60 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 17.757627 KDa
SequenceString:
VRYSLDPENP TKSCKSRGSN LRVHFKNTRE TAQAIKGMHI RKATKYLKDV TLQKQCVPFR RYNGGVGRCA QAKQWGWTQG RWPKKSAEF LLHMLKNAES NAELKGLDVD SLVIEHIQVN KAPKMRRRTY RAHGRINPYM SSPCHIEMIL TEKE

UniProtKB: Large ribosomal subunit protein uL22

+
Macromolecule #61: 60S ribosomal protein L22

MacromoleculeName: 60S ribosomal protein L22 / type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.481248 KDa
SequenceString:
VLKFTLDCTH PVEDGIMDAA NFEQFLQERI KVNGKAGNLG GGVVTIERSK SKITVTSEVP FSKRYLKYLT KKYLKKNNLR DWLRVVANS KESYELRYFQ

UniProtKB: Large ribosomal subunit protein eL22

+
Macromolecule #62: uL23

MacromoleculeName: uL23 / type: protein_or_peptide / ID: 62 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.727181 KDa
SequenceString:
KIRTSPTFRR PKTLRLRRQP KYPRKSAPRR NKLDHYAIIK FPLTTESAMK KIEDNNTLVF IVDVKANKHQ IKQAVKKLYD IDVAKVNTL IRPDGEKKAY VRLAPDYDAL DVANKIGII

+
Macromolecule #63: 60S ribosomal protein L26

MacromoleculeName: 60S ribosomal protein L26 / type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.891787 KDa
SequenceString:
MKFNPFVTSD RSKNRKRHFN APSHIRRKIM SSPLSKELRQ KYNVRSMPIR KDDEVQVVRG HYKGQQIGKV VQVYRKKYVI YIERVQREK ANGTTVHVGI HPSKVVITRL KLDKDRKKIL ERKAKSRQVG KEKGK

UniProtKB: Large ribosomal subunit protein uL24

+
Macromolecule #64: eL24

MacromoleculeName: eL24 / type: protein_or_peptide / ID: 64 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 13.719101 KDa
SequenceString:
MKVELCSFSG YKIYPGHGRR YARTDGKVFQ FLNAKCESAF LSKRNPRQIN WTVLYRRKHK KGQSRTRRAV KFQRAITGAS LADIMAKRN QKPEVRKAQR EQAIRAAKEA KKAKQASKK

+
Macromolecule #65: 60S ribosomal protein L27

MacromoleculeName: 60S ribosomal protein L27 / type: protein_or_peptide / ID: 65 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.704635 KDa
SequenceString:
GKFMKPGKVV LVLAGRYSGR KAVIVKNIDD GTSDRPYSHA LVAGIDRYPR KVTAAMGKKK IAKRSKIKSF VKVYNYNHLM PTRYSVDIP LDKTVVNKDV FRDPALKRKA RREAKVKFEE RYKTGKNKWF FQKLRF

UniProtKB: Large ribosomal subunit protein eL27

+
Macromolecule #66: 60S ribosomal protein L28

MacromoleculeName: 60S ribosomal protein L28 / type: protein_or_peptide / ID: 66 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 14.362861 KDa
SequenceString:
(SAC)AHLQWMVVR NCSSFLIKRN KQTYSTEPNN LKARNSFRYN GLIHRKTVGV EPAADGKGVV VVIKRRSGQR KPATSY VRT TINKNARATL SSIRHMIRKN KYRPDLRMAA IRRASAILRS QKPVMV

UniProtKB: Large ribosomal subunit protein eL28

+
Macromolecule #67: 60S ribosomal protein L35

MacromoleculeName: 60S ribosomal protein L35 / type: protein_or_peptide / ID: 67 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 14.462429 KDa
SequenceString:
AKIKARDLRG KKKEELLKQL DDLKVELSQL RVAKVTGGAA SKLSKIRVVR KSIARVLTVI NQTQKENLRK FYKGKKYKPL DLRPKKTRA MRRRLNKHEE NLKTKKQQRK ERLYPLRKYA VKA

UniProtKB: Large ribosomal subunit protein uL29

+
Macromolecule #68: eL29

MacromoleculeName: eL29 / type: protein_or_peptide / ID: 68 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.643145 KDa
SequenceString:
AKS(MLZ)NHTTHN QSRKWHRNGI KKPRSQRYES LKGVDPKFLR NMRFAKKHNK KGLKKMQANN AKAMSARAEA IKALVV SRK LDRLAYIAHP KLGKRARARI AKGLRLCRPK

+
Macromolecule #69: 60S ribosomal protein L7

MacromoleculeName: 60S ribosomal protein L7 / type: protein_or_peptide / ID: 69 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 26.590725 KDa
SequenceString: NFAELKIKRL RKKFAQKMLR KARRKLIYEK AKHYHKEYRQ MYRTEIRMAR MARKAGNFYV PAEPKLAFVI RIRGINGVSP KVRKVLQLL RLRQIFNGTF VKLNKASINM LRIVEPYIAW GYPNLKSVNE LIYKRGYGKI NKKRIALTDN ALIARSLGKY G IICMEDLI ...String:
NFAELKIKRL RKKFAQKMLR KARRKLIYEK AKHYHKEYRQ MYRTEIRMAR MARKAGNFYV PAEPKLAFVI RIRGINGVSP KVRKVLQLL RLRQIFNGTF VKLNKASINM LRIVEPYIAW GYPNLKSVNE LIYKRGYGKI NKKRIALTDN ALIARSLGKY G IICMEDLI HEIYTVGKRF KEANNFLWPF KLSSPRGGMK KKTTHFVEGG DAGNREDQIN RLIRRMN

UniProtKB: Large ribosomal subunit protein uL30

+
Macromolecule #70: 60S ribosomal protein L30

MacromoleculeName: 60S ribosomal protein L30 / type: protein_or_peptide / ID: 70 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 10.954884 KDa
SequenceString:
KSLESINSRL QLVMKSGKYV LGYKQTLKMI RQGKAKLVIL ANNCPALRKS EIEYYAMLAK TGVHHYSGNN IELGTACGKY YRVCTLAII DPGDSDIIR

UniProtKB: Large ribosomal subunit protein eL30

+
Macromolecule #71: 60S ribosomal protein L31

MacromoleculeName: 60S ribosomal protein L31 / type: protein_or_peptide / ID: 71 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.635694 KDa
SequenceString:
NEVVTREYTI NIHKRIHGVG FKKRAPRALK EIRKFAMKEM GTPDVRIDTR LNKAVWAKGI RNVPYRIRVR LSRKRNEDED SPNKLYTLV TYVPVTTFKN LQTVNVDE

UniProtKB: Large ribosomal subunit protein eL31

+
Macromolecule #72: 60S ribosomal protein L32

MacromoleculeName: 60S ribosomal protein L32 / type: protein_or_peptide / ID: 72 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.022021 KDa
SequenceString:
AALRPLVKPK IVKKRTKKFI RHQSDRYVKI KRNWRKPRGI DNRVRRRFKG QILMPNIGYG SNKKTKHMLP SGFRKFLVHN VKELEVLLM CNKSYCAEIA HNVSSKNRKA IVERAAQLAI RVTNPNARL

UniProtKB: Large ribosomal subunit protein eL32

+
Macromolecule #73: 60S ribosomal protein L35a

MacromoleculeName: 60S ribosomal protein L35a / type: protein_or_peptide / ID: 73 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.433548 KDa
SequenceString:
SGRLWSKAIF AGYKRGLRNQ REHTALLKIE GVYARDETEF YLGKRCAYVY KAKNNTVTPG GKPNKTRVIW GKVTRAHGNS GMVRAKFRS NLPAKAIGHR IRVMLYPSRI

UniProtKB: Large ribosomal subunit protein eL33

+
Macromolecule #74: 60S ribosomal protein L34

MacromoleculeName: 60S ribosomal protein L34 / type: protein_or_peptide / ID: 74 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.994621 KDa
SequenceString:
VQRLTYRRRL SYNTASNKTR LSRTPGNRIV YLYTKKVGKA PKSACGVCPG RLRGVRAVRP KVLMRLSKTK KHVSRAYGGS MCAKCVRDR IKRAFLIEEQ KIVVKVLKAQ AQSQK

UniProtKB: Large ribosomal subunit protein eL34

+
Macromolecule #75: 60S ribosomal protein L36

MacromoleculeName: 60S ribosomal protein L36 / type: protein_or_peptide / ID: 75 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 11.915396 KDa
SequenceString:
ALRYPMAVGL NKGHKVTKNV SKPRHSRRRG RLTKHTKFVR DMIREVCGFA PYERRAMELL KVSKDKRALK FIKKRVGTHI RAKRKREEL SNVLAAMRKA AAK

UniProtKB: Large ribosomal subunit protein eL36

+
Macromolecule #76: 60S ribosomal protein L37

MacromoleculeName: 60S ribosomal protein L37 / type: protein_or_peptide / ID: 76 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 10.090891 KDa
SequenceString:
TKGTSSFGKR RNKTHTLCRR CGSKAYHLQK STCGKCGYPA KRKRKYNWSA KAKRRNTTGT GRMRHLKIVY RRFRHGFREG TTPKPK

UniProtKB: Large ribosomal subunit protein eL37

+
Macromolecule #77: 60S ribosomal protein L38

MacromoleculeName: 60S ribosomal protein L38 / type: protein_or_peptide / ID: 77 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 8.107752 KDa
SequenceString:
PRKIEEIKDF LLTARRKDAK SVKIKKNKDN VKFKVRCSRY LYTLVITDKE KAEKLKQSLP PGLAVKELK

UniProtKB: Large ribosomal subunit protein eL38

+
Macromolecule #78: 60S ribosomal protein L39

MacromoleculeName: 60S ribosomal protein L39 / type: protein_or_peptide / ID: 78 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 6.295562 KDa
SequenceString:
SSHKTFRIKR FLAKKQKQNR PIPQWIRMKT GNKIRYNSKR RHWRRTKLGL

UniProtKB: Large ribosomal subunit protein eL39

+
Macromolecule #79: eL40

MacromoleculeName: eL40 / type: protein_or_peptide / ID: 79 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 6.241654 KDa
SequenceString:
IIEPSLRQLA QKYNCDKMIC R(M3L)CYARLHPR AVNCRKKKCG HTNNLRPKKK VK

+
Macromolecule #80: 60S ribosomal protein L41

MacromoleculeName: 60S ribosomal protein L41 / type: protein_or_peptide / ID: 80 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 3.473451 KDa
SequenceString:
MRAKWRKKRM RRLKRKRRKM RQRSK

UniProtKB: Small ribosomal subunit protein eS32

+
Macromolecule #81: Ribosomal protein L36a

MacromoleculeName: Ribosomal protein L36a / type: protein_or_peptide / ID: 81 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 12.358795 KDa
SequenceString:
VNVPKTRRTF CKKCGKHQPH KVTQYKKGKD SLYAQGKRRY DRKQSGYGGQ T(MLZ)PIFRKKAK TTKKIVLRLE CVEPNC RSK RMLAIKRCKH FELGGDKKRK GQVIQF

UniProtKB: Large ribosomal subunit protein eL42

+
Macromolecule #82: 60S ribosomal protein L37a

MacromoleculeName: 60S ribosomal protein L37a / type: protein_or_peptide / ID: 82 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 10.168153 KDa
SequenceString:
AKRTKKVGIV GKYGTRYGAS LRKMVKKIEI SQHAKYTCSF CGKTKMKRRA VGIWHCGSCM KTVAGGAWTY NTTSAVTVKS AIRRLKELK DQ

UniProtKB: Large ribosomal subunit protein eL43

+
Macromolecule #86: eIF5A1

MacromoleculeName: eIF5A1 / type: protein_or_peptide / ID: 86 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 15.716057 KDa
Recombinant expressionOrganism: Escherichia coli (E. coli)
SequenceString:
DAGASATFPM QCSALRKNGF VVLKGRPCKI VEMSTSKTG(5CT) HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKR NDF QLIGIQDGYL SLLQDSGEVR EDLRLPEGDL GKEIEQKYDC GEEILITVLS AMTEEAAVAI KAMA

+
Macromolecule #87: Elongation factor 1-alpha 1

MacromoleculeName: Elongation factor 1-alpha 1 / type: protein_or_peptide / ID: 87 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 48.51982 KDa
SequenceString: EKTHINIVVI GHVDSGKSTT TGHLIYKCGG ID(M3L)RTIEKFE KEAAEMGKGS F(MLY)YAWVLDKL KAERERGITI DI SLW(M3L)FET SKYYVTIIDA PGHRDFIKNM ITGTSQADCA VLIVAAGVGE FEAGISKNGQ TREHALLAYT LGVKQLIVG VNKMDSTEPP ...String:
EKTHINIVVI GHVDSGKSTT TGHLIYKCGG ID(M3L)RTIEKFE KEAAEMGKGS F(MLY)YAWVLDKL KAERERGITI DI SLW(M3L)FET SKYYVTIIDA PGHRDFIKNM ITGTSQADCA VLIVAAGVGE FEAGISKNGQ TREHALLAYT LGVKQLIVG VNKMDSTEPP YSQKRYEEIV KEVSTYIKKI GYNPDTVAFV PISGWNGDNM LEPSANMPWF KGWKVTRKDG NASGTTLLEA LDCILPPTR PTDKPLRLPL QDVYKIGGIG TVPVGRVETG VLKPGMVVTF APVNVTTEVK SVEMHHEALS EALPGDNVGF N VKNVSV(M3L)D VRRGNVAGDS KNDPPMEAAG FTAQVIILNH PGQISAGYAP VLDCHTAHIA CKFAELKEKI DRRSGKKL E DGPKFLKSGD AAIVDMVPGK PMCVESFSDY PPLGRFAVRD MRQTVAVGVI KAVDKKAAG

UniProtKB: Elongation factor 1-alpha 1

+
Macromolecule #88: SPERMIDINE

MacromoleculeName: SPERMIDINE / type: ligand / ID: 88 / Number of copies: 10 / Formula: SPD
Molecular weightTheoretical: 145.246 Da
Chemical component information

ChemComp-SPD:
SPERMIDINE

+
Macromolecule #89: POTASSIUM ION

MacromoleculeName: POTASSIUM ION / type: ligand / ID: 89 / Number of copies: 45 / Formula: K
Molecular weightTheoretical: 39.098 Da

+
Macromolecule #90: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 90 / Number of copies: 433 / Formula: MG
Molecular weightTheoretical: 24.305 Da

+
Macromolecule #91: ANISOMYCIN

MacromoleculeName: ANISOMYCIN / type: ligand / ID: 91 / Number of copies: 1 / Formula: ANM
Molecular weightTheoretical: 265.305 Da
Chemical component information

ChemComp-ANM:
ANISOMYCIN / antibiotic*YM

+
Macromolecule #92: 1,4-DIAMINOBUTANE

MacromoleculeName: 1,4-DIAMINOBUTANE / type: ligand / ID: 92 / Number of copies: 8 / Formula: PUT
Molecular weightTheoretical: 88.151 Da
Chemical component information

ChemComp-PUT:
1,4-DIAMINOBUTANE

+
Macromolecule #93: 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12...

MacromoleculeName: 4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione
type: ligand / ID: 93 / Number of copies: 1 / Formula: 3H3
Molecular weightTheoretical: 457.559 Da
Chemical component information

ChemComp-3H3:
4-{(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4E,6Z,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-en-1-yl}piperidine-2,6-dione

+
Macromolecule #94: ZINC ION

MacromoleculeName: ZINC ION / type: ligand / ID: 94 / Number of copies: 8 / Formula: ZN
Molecular weightTheoretical: 65.409 Da

+
Macromolecule #95: PHENYLALANINE

MacromoleculeName: PHENYLALANINE / type: ligand / ID: 95 / Number of copies: 1 / Formula: PHE
Molecular weightTheoretical: 165.189 Da
Chemical component information

ChemComp-PHE:
PHENYLALANINE

+
Macromolecule #96: METHIONINE

MacromoleculeName: METHIONINE / type: ligand / ID: 96 / Number of copies: 1 / Formula: MET
Molecular weightTheoretical: 149.211 Da
Chemical component information

ChemComp-MET:
METHIONINE

+
Macromolecule #97: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

MacromoleculeName: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE / type: ligand / ID: 97 / Number of copies: 1 / Formula: GSP
Molecular weightTheoretical: 539.246 Da
Chemical component information

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

+
Macromolecule #98: plitidepsin

MacromoleculeName: plitidepsin / type: ligand / ID: 98 / Number of copies: 1 / Formula: ZIY
Molecular weightTheoretical: 1.110339 KDa
Chemical component information

ChemComp-ZIY:
plitidepsin

+
Macromolecule #99: water

MacromoleculeName: water / type: ligand / ID: 99 / Number of copies: 365 / Formula: HOH
Molecular weightTheoretical: 18.015 Da
Chemical component information

ChemComp-HOH:
WATER

-
Experimental details

-
Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

-
Sample preparation

BufferpH: 7.5
GridModel: Quantifoil R1.2/1.3 / Material: GOLD / Mesh: 300
VitrificationCryogen name: ETHANE

-
Electron microscopy

MicroscopeFEI TITAN KRIOS
Image recordingFilm or detector model: GATAN K3 (6k x 4k) / Average electron dose: 79.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD / Nominal defocus max: 1.5 µm / Nominal defocus min: 0.5 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

+
Image processing

Startup modelType of model: NONE
Final reconstructionResolution.type: BY AUTHOR / Resolution: 2.64 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 20290
Initial angle assignmentType: MAXIMUM LIKELIHOOD
Final angle assignmentType: MAXIMUM LIKELIHOOD
FSC plot (resolution estimation)

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